Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review

Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review

Cholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC) and carries a high rate of mortality. Although the pathogenesis of CCA in PSC is largely unknown, inflammation-driven carcinogenesis concomitant with various genetic and epigenetic abnormalit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical reviews in allergy & immunology 2020-02, Vol.58 (1), p.134-149
Hauptverfasser: Song, Junmin, Li, Yang, Bowlus, Christopher L., Yang, GuoXiang, Leung, Patrick S. C., Gershwin, M. Eric
Format: Artikel
Sprache:eng
Schlagworte:
Allergology
Bile
Bile ducts
Carcinogenesis
Care and treatment
Cholangiocarcinoma
Cholangitis
Crohn's disease
Development and progression
Diagnosis
Epigenetic inheritance
Health aspects
Immunology
Incidence
Inflammation
Internal Medicine
Jaundice
Liver
Males
Malignancy
Medicine
Medicine & Public Health
Mortality
Pain
Pathogenesis
Patients
Pruritus
Risk factors
Stricture
Tumors
Ulcerative colitis
Weight loss
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC) and carries a high rate of mortality. Although the pathogenesis of CCA in PSC is largely unknown, inflammation-driven carcinogenesis concomitant with various genetic and epigenetic abnormalities are underlying factors. The majority of CCA cases develop from a dominant stricture (DS), which is defined as a stricture with a diameter
ISSN:1080-0549
1559-0267
DOI:10.1007/s12016-019-08764-7