Update 2020: nomenclature and listing of celiac disease–relevant gluten epitopes recognized by CD4+ T cells

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4 + T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease...

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Veröffentlicht in:	Immunogenetics (New York) 2020-02, Vol.72 (1-2), p.85-88
Hauptverfasser:	Sollid, Ludvig M., Tye-Din, Jason A., Qiao, Shuo-Wang, Anderson, Robert P., Gianfrani, Carmen, Koning, Frits
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Allotypes Animals Antigens Autoimmune diseases Biomedical and Life Sciences Biomedicine CD4 antigen CD4-Positive T-Lymphocytes - immunology Celiac disease Celiac Disease - immunology Cell Biology databases and bioinformatics in Immunogenetics Epitopes Epitopes, T-Lymphocyte - immunology Gene Function Genetics & Heredity Gluten Glutens - immunology Histocompatibility antigen HLA Human Genetics Humans Immunology Intestine Leukocytes Life Sciences & Biomedicine Lymphocytes Lymphocytes T Major Histocompatibility Complex - immunology Nomenclature Review Science & Technology Terminology as Topic
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Beschreibung
Zusammenfassung:	Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4 + T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.
ISSN:	0093-7711 1432-1211
DOI:	10.1007/s00251-019-01141-w