Effects of 1,25-Dihydroxy vitamin D-3 on TNF-alpha induced inflammation in human chondrocytes and SW1353 cells: a possible role for toll-like receptors

The purpose of this study is to evaluate anti-inflammatory and chondro-protective effects of 1,25(OH)(2)D-3 in human chondrocytes and SW1353 cells via investigating expressions of MMPs, TIMPs, VDR, and intracellular signalling pathway mediators such as TLR-2 and -4. The HC and SW1353 cells were trea...

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Veröffentlicht in:	Molecular and cellular biochemistry 2020-01, Vol.464 (1-2), p.131-142
Hauptverfasser:	Avcioglu, Gamze, Iptec, Betul Ozbek, Akcan, Gulben, Gorgun, Busra, Fidan, Kubra, Carhan, Ahmet, Yilmaz, Gulsen, Kozaci, Leyla Didem
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcitriol - pharmacology Cell Biology Cell Line Cell Proliferation - drug effects Chondrocytes - metabolism Chondrocytes - pathology Collagenases - biosynthesis Humans Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Life Sciences & Biomedicine Science & Technology Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - pharmacology
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