Solid lipid nanoparticles enhance the resistance of oat-derived peptides that inhibit dipeptidyl peptidase IV in simulated gastrointestinal fluids

[Display omitted] •Solid lipid nanoparticle is used to embed the DPP4 inhibitory peptides.•Encapsulation efficiencies of peptide fractions within liposome are over 69%.•Particle size of peptides affects encapsulation efficiency.•Nanoparticle improves the stability of oat peptides in the gastrointestinal tract.•Short peptide SLN is of high crystallinity and easy to be dispersed. In this study, we investigated the effects of solid lipid nanoparticle (SLN) nanocrystallization on the stability of two fractions of oat globulin-derived peptides. i.e., OGL, with molecular weight (MW)