Reactivation of Plasmodium infection during a treatment with infliximab: A case report

•Plasmodium falciparum may reactivate in immunosuppressed patients.•Prevalence and physiopathology of persistence of Plasmodium falciparum are not well known.•Affordable and sensitive techniques such as LAMP are useful for this purpose. We describe a symptomatic Plasmodium falciparum infection in a...

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Veröffentlicht in:	International journal of infectious diseases 2020-02, Vol.91, p.101-103
Hauptverfasser:	Haeseleer, C., Martiny, D., Van Laethem, Y., Cantinieaux, B., Martin, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Humans Infectious Diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy Infliximab Infliximab - adverse effects Infliximab - therapeutic use Life Sciences & Biomedicine Low parasitemia Malaria Malaria, Falciparum - etiology Male Non-endemic areas Plasmodium falciparum Reactivation Science & Technology Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Zusammenfassung:	•Plasmodium falciparum may reactivate in immunosuppressed patients.•Prevalence and physiopathology of persistence of Plasmodium falciparum are not well known.•Affordable and sensitive techniques such as LAMP are useful for this purpose. We describe a symptomatic Plasmodium falciparum infection in a 29-year-old Guinean man receiving Infliximab for one year and without recent travel. The reactivation of submicroscopic malaria following the inhibition of TNF-alpha by infliximab is suspected.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2019.11.016