Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis
Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index...
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| Veröffentlicht in: | Journal of neuroimmunology 2020-02, Vol.339, p.577108-577108, Article 577108 |
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| creator | Gaetani, Lorenzo Di Carlo, Marinella Brachelente, Giovanni Valletta, Federico Eusebi, Paolo Mancini, Andrea Gentili, Lucia Borrelli, Angela Calabresi, Paolo Sarchielli, Paola Ferri, Carla Villa, Alfredo Di Filippo, Massimiliano |
| description | Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p 10.61 significantly predicted time to conversion to MS (p = .020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.
[Display omitted]
•κ-index is more sensitive and less specific than OCB for MS diagnosis.•κ-index performs better than OCB in discriminating MS from other inflammatory neurological diseases.•κ-index correlates with different disease characteristics in MS.•κ-index predicts disease activity in early MS patients. |
| doi_str_mv | 10.1016/j.jneuroim.2019.577108 |
| format | Article |
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[Display omitted]
•κ-index is more sensitive and less specific than OCB for MS diagnosis.•κ-index performs better than OCB in discriminating MS from other inflammatory neurological diseases.•κ-index correlates with different disease characteristics in MS.•κ-index predicts disease activity in early MS patients.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2019.577108</identifier><identifier>PMID: 31743879</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Biomarker ; Cerebrospinal fluid ; Free light chains ; Immunology ; Kappa index ; Life Sciences & Biomedicine ; Multiple sclerosis ; Neurosciences ; Neurosciences & Neurology ; Science & Technology</subject><ispartof>Journal of neuroimmunology, 2020-02, Vol.339, p.577108-577108, Article 577108</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>38</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000510528000011</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c368t-603338870a8f252541f914588a4bbd522b865478325648b516d451c4650c55113</citedby><cites>FETCH-LOGICAL-c368t-603338870a8f252541f914588a4bbd522b865478325648b516d451c4650c55113</cites><orcidid>0000-0003-0817-4729 ; 0000-0002-0715-6396 ; 0000-0003-0326-5509 ; 0000-0002-7595-9246</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2019.577108$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,28257,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31743879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaetani, Lorenzo</creatorcontrib><creatorcontrib>Di Carlo, Marinella</creatorcontrib><creatorcontrib>Brachelente, Giovanni</creatorcontrib><creatorcontrib>Valletta, Federico</creatorcontrib><creatorcontrib>Eusebi, Paolo</creatorcontrib><creatorcontrib>Mancini, Andrea</creatorcontrib><creatorcontrib>Gentili, Lucia</creatorcontrib><creatorcontrib>Borrelli, Angela</creatorcontrib><creatorcontrib>Calabresi, Paolo</creatorcontrib><creatorcontrib>Sarchielli, Paola</creatorcontrib><creatorcontrib>Ferri, Carla</creatorcontrib><creatorcontrib>Villa, Alfredo</creatorcontrib><creatorcontrib>Di Filippo, Massimiliano</creatorcontrib><title>Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J NEUROIMMUNOL</addtitle><addtitle>J Neuroimmunol</addtitle><description>Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p < .001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p = .020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.
[Display omitted]
•κ-index is more sensitive and less specific than OCB for MS diagnosis.•κ-index performs better than OCB in discriminating MS from other inflammatory neurological diseases.•κ-index correlates with different disease characteristics in MS.•κ-index predicts disease activity in early MS patients.</description><subject>Biomarker</subject><subject>Cerebrospinal fluid</subject><subject>Free light chains</subject><subject>Immunology</subject><subject>Kappa index</subject><subject>Life Sciences & Biomedicine</subject><subject>Multiple sclerosis</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Science & Technology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkE1v1DAQhi0EotuWv1D5iISy-DNxbqCofEiVeilny3YmrRcnDnZCxb_H22x7hdNYmucdzzwIXVGyp4TWHw_7wwRrin7cM0LbvWwaStQrtKOqYZUSjL5GuwLKSjZMnaHznA-EUMlF-xadcdoIrpp2h-47SGBTzLOfTMBDWH2PhwSAg79_WLB7MH7K2MVxNgl6vEQcSye6EI-8NVOfscnY-jia9BNSxn7C4xoWPwfA2QUow32-RG8GEzK8O9UL9OPL9V33rbq5_fq9-3xTOV6rpaoJ51yphhg1MMmkoENLhVTKCGt7yZhVtRSN4kzWQllJ615I6kQtiZOSUn6B3m9z5xR_rZAXPfrsIAQzQVyzZpzWgrWtagpab6grG-YEg56TL0f80ZToo2R90M-S9VGy3iSX4NXpj9WO0L_Enq0W4MMGPIKNQ3YeJgcvGCFEUiKZKg_ytLL6f7rzi1l8nLq4TkuJftqiUJT-9pD0Kd77BG7RffT_OuYvgCCxbQ</recordid><startdate>20200215</startdate><enddate>20200215</enddate><creator>Gaetani, Lorenzo</creator><creator>Di Carlo, Marinella</creator><creator>Brachelente, Giovanni</creator><creator>Valletta, Federico</creator><creator>Eusebi, Paolo</creator><creator>Mancini, Andrea</creator><creator>Gentili, Lucia</creator><creator>Borrelli, Angela</creator><creator>Calabresi, Paolo</creator><creator>Sarchielli, Paola</creator><creator>Ferri, Carla</creator><creator>Villa, Alfredo</creator><creator>Di Filippo, Massimiliano</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0817-4729</orcidid><orcidid>https://orcid.org/0000-0002-0715-6396</orcidid><orcidid>https://orcid.org/0000-0003-0326-5509</orcidid><orcidid>https://orcid.org/0000-0002-7595-9246</orcidid></search><sort><creationdate>20200215</creationdate><title>Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis</title><author>Gaetani, Lorenzo ; Di Carlo, Marinella ; Brachelente, Giovanni ; Valletta, Federico ; Eusebi, Paolo ; Mancini, Andrea ; Gentili, Lucia ; Borrelli, Angela ; Calabresi, Paolo ; Sarchielli, Paola ; Ferri, Carla ; Villa, Alfredo ; Di Filippo, Massimiliano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-603338870a8f252541f914588a4bbd522b865478325648b516d451c4650c55113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarker</topic><topic>Cerebrospinal fluid</topic><topic>Free light chains</topic><topic>Immunology</topic><topic>Kappa index</topic><topic>Life Sciences & Biomedicine</topic><topic>Multiple sclerosis</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaetani, Lorenzo</creatorcontrib><creatorcontrib>Di Carlo, Marinella</creatorcontrib><creatorcontrib>Brachelente, Giovanni</creatorcontrib><creatorcontrib>Valletta, Federico</creatorcontrib><creatorcontrib>Eusebi, Paolo</creatorcontrib><creatorcontrib>Mancini, Andrea</creatorcontrib><creatorcontrib>Gentili, Lucia</creatorcontrib><creatorcontrib>Borrelli, Angela</creatorcontrib><creatorcontrib>Calabresi, Paolo</creatorcontrib><creatorcontrib>Sarchielli, Paola</creatorcontrib><creatorcontrib>Ferri, Carla</creatorcontrib><creatorcontrib>Villa, Alfredo</creatorcontrib><creatorcontrib>Di Filippo, Massimiliano</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaetani, Lorenzo</au><au>Di Carlo, Marinella</au><au>Brachelente, Giovanni</au><au>Valletta, Federico</au><au>Eusebi, Paolo</au><au>Mancini, Andrea</au><au>Gentili, Lucia</au><au>Borrelli, Angela</au><au>Calabresi, Paolo</au><au>Sarchielli, Paola</au><au>Ferri, Carla</au><au>Villa, Alfredo</au><au>Di Filippo, Massimiliano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><stitle>J NEUROIMMUNOL</stitle><addtitle>J Neuroimmunol</addtitle><date>2020-02-15</date><risdate>2020</risdate><volume>339</volume><spage>577108</spage><epage>577108</epage><pages>577108-577108</pages><artnum>577108</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal bands (OCB) in multiple sclerosis (MS). Herein, we compared the diagnostic accuracy of CSF OCB and FLC and we tested the prognostic value of FLC in a cohort of 64 MS patients and 106 controls. A κ-index >7.83 was more sensitive but less specific than OCB in discriminating MS patients from controls. Additionally, a κ-index >10.61 performed better than OCB in the discrimination between MS and controls with inflammatory neurological diseases (p < .001). In clinically isolated syndrome (CIS) patients, a κ-index >10.61 significantly predicted time to conversion to MS (p = .020). κ-index might be a valid alternative to OCB as a diagnostic biomarker for MS and might also be a prognostic marker in CIS.
[Display omitted]
•κ-index is more sensitive and less specific than OCB for MS diagnosis.•κ-index performs better than OCB in discriminating MS from other inflammatory neurological diseases.•κ-index correlates with different disease characteristics in MS.•κ-index predicts disease activity in early MS patients.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>31743879</pmid><doi>10.1016/j.jneuroim.2019.577108</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0817-4729</orcidid><orcidid>https://orcid.org/0000-0002-0715-6396</orcidid><orcidid>https://orcid.org/0000-0003-0326-5509</orcidid><orcidid>https://orcid.org/0000-0002-7595-9246</orcidid></addata></record> |
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| subjects | Biomarker Cerebrospinal fluid Free light chains Immunology Kappa index Life Sciences & Biomedicine Multiple sclerosis Neurosciences Neurosciences & Neurology Science & Technology |
| title | Cerebrospinal fluid free light chains compared to oligoclonal bands as biomarkers in multiple sclerosis |
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