Infection and atherosclerosis: TLR-dependent pathways
Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like...
Gespeichert in:
| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2020-07, Vol.77 (14), p.2751-2769 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2769 |
|---|---|
| container_issue | 14 |
| container_start_page | 2751 |
| container_title | Cellular and molecular life sciences : CMLS |
| container_volume | 77 |
| creator | Li, Bowei Xia, Yuanpeng Hu, Bo |
| description | Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like hyperlipidemia, hypertension, smoking and obesity, emerging evidence suggests that atherosclerosis is a chronic inflammatory disease, suggesting that chronic infection plays an important role in the development of atherosclerosis. Toll-like receptors (TLRs) are the most characteristic members of pattern recognition receptors (PRRs), which play an important role in innate immune mechanism. TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as
Chlamydia pneumoniae
(
C. pneumoniae
)
,
periodontal pathogens including
Porphyromonas gingivalis
(
P. gingivalis
)
, Helicobacter pylori
(
H. pylori
) and
human immunodeficiency virus
(HIV). Overall, activation of TLR2 and 4 seems to have a profound impact on infection-related atherosclerosis. This article reviews the role of TLRs in the process of atherosclerosis after
C. pneumoniae
and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD. |
| doi_str_mv | 10.1007/s00018-020-03453-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000510282700001CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2350093650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-5f0de0d1a82ebdc2893dc81cbdaba958f658c6ff60cb5a9a0fb0f3b00434e8ac3</originalsourceid><addsrcrecordid>eNqNkVtr3DAQhUVoSdI0fyAPZaEvheJmJFm2nIdCWXoJLBRCCn0TsjRKHLzSxrIb8u87W2-3l4fSF12Y7xzN6DB2xuENB6jPMwBwXYCAAmSpZFEfsGNe0rWBmj_ZnSstvh6xZznfEa20qA7ZkRQAQml9zNRlDOjGLsWFjX5hx1scUnb9du3yxeJ6dVV43GD0GMfFhuoP9jE_Z0-D7TOe7vYT9uXD--vlp2L1-ePl8t2qcKqEsVABPILnVgtsvRO6kd5p7lpvW9soHSqlXRVCBa5VtrEQWgiyBShlido6ecLezr6bqV2jd9TDYHuzGbq1HR5Nsp35sxK7W3OTvplaCMlrTQavdgZDup8wj2bdZYd9byOmKRshFUAjKwWEvvwLvUvTEGk8I0qudVMJLYgSM-Xog_KAYd8MB7NNxcypGErF_EjF1CR68fsYe8nPGAjQM_CAbQrZdRgd7jEyVBzo9Rq23stutNvAlmmKI0lf_7-UaDnTmYh4g8OvIf_R_3faKLlo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2418896282</pqid></control><display><type>article</type><title>Infection and atherosclerosis: TLR-dependent pathways</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><creator>Li, Bowei ; Xia, Yuanpeng ; Hu, Bo</creator><creatorcontrib>Li, Bowei ; Xia, Yuanpeng ; Hu, Bo</creatorcontrib><description>Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like hyperlipidemia, hypertension, smoking and obesity, emerging evidence suggests that atherosclerosis is a chronic inflammatory disease, suggesting that chronic infection plays an important role in the development of atherosclerosis. Toll-like receptors (TLRs) are the most characteristic members of pattern recognition receptors (PRRs), which play an important role in innate immune mechanism. TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as
Chlamydia pneumoniae
(
C. pneumoniae
)
,
periodontal pathogens including
Porphyromonas gingivalis
(
P. gingivalis
)
, Helicobacter pylori
(
H. pylori
) and
human immunodeficiency virus
(HIV). Overall, activation of TLR2 and 4 seems to have a profound impact on infection-related atherosclerosis. This article reviews the role of TLRs in the process of atherosclerosis after
C. pneumoniae
and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-020-03453-7</identifier><identifier>PMID: 32002588</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - complications ; Atherosclerosis - genetics ; Atherosclerosis - microbiology ; Atherosclerosis - virology ; Bacterial Infections - complications ; Bacterial Infections - genetics ; Bacterial Infections - microbiology ; Bacterial Infections - virology ; Biochemistry ; Biochemistry & Molecular Biology ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cerebral infarction ; Chlamydia ; Chlamydophila pneumoniae - pathogenicity ; Chronic infection ; Helicobacter pylori ; Helicobacter pylori - pathogenicity ; HIV ; HIV - pathogenicity ; HIV Infections - complications ; HIV Infections - genetics ; HIV Infections - microbiology ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; Hyperlipidemia ; Hypertension ; Immune system ; Infections ; Inflammatory diseases ; Life Sciences ; Life Sciences & Biomedicine ; Myocardial infarction ; Pathogens ; Pattern recognition ; Pattern recognition receptors ; Porphyromonas gingivalis - pathogenicity ; Proteins ; Receptors ; Review ; Risk analysis ; Risk factors ; Science & Technology ; Sexually transmitted diseases ; STD ; Therapeutic applications ; TLR2 protein ; Toll-like receptors ; Toll-Like Receptors - genetics ; Vascular diseases ; Viruses</subject><ispartof>Cellular and molecular life sciences : CMLS, 2020-07, Vol.77 (14), p.2751-2769</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>94</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000510282700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c540t-5f0de0d1a82ebdc2893dc81cbdaba958f658c6ff60cb5a9a0fb0f3b00434e8ac3</citedby><cites>FETCH-LOGICAL-c540t-5f0de0d1a82ebdc2893dc81cbdaba958f658c6ff60cb5a9a0fb0f3b00434e8ac3</cites><orcidid>0000-0003-1462-8854 ; 0000-0002-5624-9361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223178/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223178/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,28255,41495,42564,51326,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32002588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Bowei</creatorcontrib><creatorcontrib>Xia, Yuanpeng</creatorcontrib><creatorcontrib>Hu, Bo</creatorcontrib><title>Infection and atherosclerosis: TLR-dependent pathways</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>CELL MOL LIFE SCI</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like hyperlipidemia, hypertension, smoking and obesity, emerging evidence suggests that atherosclerosis is a chronic inflammatory disease, suggesting that chronic infection plays an important role in the development of atherosclerosis. Toll-like receptors (TLRs) are the most characteristic members of pattern recognition receptors (PRRs), which play an important role in innate immune mechanism. TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as
Chlamydia pneumoniae
(
C. pneumoniae
)
,
periodontal pathogens including
Porphyromonas gingivalis
(
P. gingivalis
)
, Helicobacter pylori
(
H. pylori
) and
human immunodeficiency virus
(HIV). Overall, activation of TLR2 and 4 seems to have a profound impact on infection-related atherosclerosis. This article reviews the role of TLRs in the process of atherosclerosis after
C. pneumoniae
and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - microbiology</subject><subject>Atherosclerosis - virology</subject><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - genetics</subject><subject>Bacterial Infections - microbiology</subject><subject>Bacterial Infections - virology</subject><subject>Biochemistry</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cerebral infarction</subject><subject>Chlamydia</subject><subject>Chlamydophila pneumoniae - pathogenicity</subject><subject>Chronic infection</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - pathogenicity</subject><subject>HIV</subject><subject>HIV - pathogenicity</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - microbiology</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Immune system</subject><subject>Infections</subject><subject>Inflammatory diseases</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Myocardial infarction</subject><subject>Pathogens</subject><subject>Pattern recognition</subject><subject>Pattern recognition receptors</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><subject>Proteins</subject><subject>Receptors</subject><subject>Review</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Therapeutic applications</subject><subject>TLR2 protein</subject><subject>Toll-like receptors</subject><subject>Toll-Like Receptors - genetics</subject><subject>Vascular diseases</subject><subject>Viruses</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkVtr3DAQhUVoSdI0fyAPZaEvheJmJFm2nIdCWXoJLBRCCn0TsjRKHLzSxrIb8u87W2-3l4fSF12Y7xzN6DB2xuENB6jPMwBwXYCAAmSpZFEfsGNe0rWBmj_ZnSstvh6xZznfEa20qA7ZkRQAQml9zNRlDOjGLsWFjX5hx1scUnb9du3yxeJ6dVV43GD0GMfFhuoP9jE_Z0-D7TOe7vYT9uXD--vlp2L1-ePl8t2qcKqEsVABPILnVgtsvRO6kd5p7lpvW9soHSqlXRVCBa5VtrEQWgiyBShlido6ecLezr6bqV2jd9TDYHuzGbq1HR5Nsp35sxK7W3OTvplaCMlrTQavdgZDup8wj2bdZYd9byOmKRshFUAjKwWEvvwLvUvTEGk8I0qudVMJLYgSM-Xog_KAYd8MB7NNxcypGErF_EjF1CR68fsYe8nPGAjQM_CAbQrZdRgd7jEyVBzo9Rq23stutNvAlmmKI0lf_7-UaDnTmYh4g8OvIf_R_3faKLlo</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Li, Bowei</creator><creator>Xia, Yuanpeng</creator><creator>Hu, Bo</creator><general>Springer International Publishing</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1462-8854</orcidid><orcidid>https://orcid.org/0000-0002-5624-9361</orcidid></search><sort><creationdate>20200701</creationdate><title>Infection and atherosclerosis: TLR-dependent pathways</title><author>Li, Bowei ; Xia, Yuanpeng ; Hu, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-5f0de0d1a82ebdc2893dc81cbdaba958f658c6ff60cb5a9a0fb0f3b00434e8ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - microbiology</topic><topic>Atherosclerosis - virology</topic><topic>Bacterial Infections - complications</topic><topic>Bacterial Infections - genetics</topic><topic>Bacterial Infections - microbiology</topic><topic>Bacterial Infections - virology</topic><topic>Biochemistry</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cerebral infarction</topic><topic>Chlamydia</topic><topic>Chlamydophila pneumoniae - pathogenicity</topic><topic>Chronic infection</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - pathogenicity</topic><topic>HIV</topic><topic>HIV - pathogenicity</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - microbiology</topic><topic>HIV Infections - virology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Immune system</topic><topic>Infections</topic><topic>Inflammatory diseases</topic><topic>Life Sciences</topic><topic>Life Sciences & Biomedicine</topic><topic>Myocardial infarction</topic><topic>Pathogens</topic><topic>Pattern recognition</topic><topic>Pattern recognition receptors</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Review</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Therapeutic applications</topic><topic>TLR2 protein</topic><topic>Toll-like receptors</topic><topic>Toll-Like Receptors - genetics</topic><topic>Vascular diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Bowei</creatorcontrib><creatorcontrib>Xia, Yuanpeng</creatorcontrib><creatorcontrib>Hu, Bo</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Bowei</au><au>Xia, Yuanpeng</au><au>Hu, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infection and atherosclerosis: TLR-dependent pathways</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><stitle>CELL MOL LIFE SCI</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>77</volume><issue>14</issue><spage>2751</spage><epage>2769</epage><pages>2751-2769</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course over many years, but it can cause acute clinical events, including acute coronary syndromes (ACS), myocardial infarction (MI) and stroke. In addition to a series of typical risk factors for atherosclerosis, like hyperlipidemia, hypertension, smoking and obesity, emerging evidence suggests that atherosclerosis is a chronic inflammatory disease, suggesting that chronic infection plays an important role in the development of atherosclerosis. Toll-like receptors (TLRs) are the most characteristic members of pattern recognition receptors (PRRs), which play an important role in innate immune mechanism. TLRs play different roles in different stages of infection of atherosclerosis-related pathogens such as
Chlamydia pneumoniae
(
C. pneumoniae
)
,
periodontal pathogens including
Porphyromonas gingivalis
(
P. gingivalis
)
, Helicobacter pylori
(
H. pylori
) and
human immunodeficiency virus
(HIV). Overall, activation of TLR2 and 4 seems to have a profound impact on infection-related atherosclerosis. This article reviews the role of TLRs in the process of atherosclerosis after
C. pneumoniae
and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32002588</pmid><doi>10.1007/s00018-020-03453-7</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0003-1462-8854</orcidid><orcidid>https://orcid.org/0000-0002-5624-9361</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-682X |
| ispartof | Cellular and molecular life sciences : CMLS, 2020-07, Vol.77 (14), p.2751-2769 |
| issn | 1420-682X 1420-9071 |
| language | eng |
| recordid | cdi_webofscience_primary_000510282700001CitationCount |
| source | MEDLINE; Springer Online Journals Complete; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central |
| subjects | Arteriosclerosis Atherosclerosis Atherosclerosis - complications Atherosclerosis - genetics Atherosclerosis - microbiology Atherosclerosis - virology Bacterial Infections - complications Bacterial Infections - genetics Bacterial Infections - microbiology Bacterial Infections - virology Biochemistry Biochemistry & Molecular Biology Biomedical and Life Sciences Biomedicine Cell Biology Cerebral infarction Chlamydia Chlamydophila pneumoniae - pathogenicity Chronic infection Helicobacter pylori Helicobacter pylori - pathogenicity HIV HIV - pathogenicity HIV Infections - complications HIV Infections - genetics HIV Infections - microbiology HIV Infections - virology Human immunodeficiency virus Humans Hyperlipidemia Hypertension Immune system Infections Inflammatory diseases Life Sciences Life Sciences & Biomedicine Myocardial infarction Pathogens Pattern recognition Pattern recognition receptors Porphyromonas gingivalis - pathogenicity Proteins Receptors Review Risk analysis Risk factors Science & Technology Sexually transmitted diseases STD Therapeutic applications TLR2 protein Toll-like receptors Toll-Like Receptors - genetics Vascular diseases Viruses |
| title | Infection and atherosclerosis: TLR-dependent pathways |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T01%3A59%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Infection%20and%20atherosclerosis:%20TLR-dependent%20pathways&rft.jtitle=Cellular%20and%20molecular%20life%20sciences%20:%20CMLS&rft.au=Li,%20Bowei&rft.date=2020-07-01&rft.volume=77&rft.issue=14&rft.spage=2751&rft.epage=2769&rft.pages=2751-2769&rft.issn=1420-682X&rft.eissn=1420-9071&rft_id=info:doi/10.1007/s00018-020-03453-7&rft_dat=%3Cproquest_webof%3E2350093650%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2418896282&rft_id=info:pmid/32002588&rfr_iscdi=true |