Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity

Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity

The natural killer group 2D (NKG2D) receptor and its ligands play important roles in immune surveillance. In this study, we observed that the average serum soluble MICA (sMICA) concentration of 174 hepatocellular carcinoma (HCC) patients was significantly higher than that in 80 healthy subjects (602...

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Veröffentlicht in:Aging and disease 2020-02, Vol.11 (1), p.118-128
Hauptverfasser: Luo, Qizhi, Luo, Weiguang, Zhu, Quan, Huang, Hongjun, Peng, Huiyun, Liu, Rongjiao, Xie, Min, Li, Shili, Li, Ming, Hu, Xiaocui, Zou, Yizhou
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Carcinoma
Hepatocellular carcinoma
Intelligence gathering
Killer cells
Liver cancer
Orginal
Time
Tumors
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Zusammenfassung:The natural killer group 2D (NKG2D) receptor and its ligands play important roles in immune surveillance. In this study, we observed that the average serum soluble MICA (sMICA) concentration of 174 hepatocellular carcinoma (HCC) patients was significantly higher than that in 80 healthy subjects (602.17 ± 338.15 vs. 72.26 ± 87.88 pg/ml, t = 3.107, P=0.002). The levels of serum sMICA in 44 HCC patients with initial levels above 400 pg/ml declined significantly after surgical removal of the liver cancer tissue (P
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2019.1017