Engineered Protein Scaffolds as Next-Generation Therapeutics

The concept of engineering robust protein scaffolds for novel binding functions emerged 20 years ago, one decade after the advent of recombinant antibody technology. Early examples were the Affibody, Monobody (Adnectin), and Anticalin proteins, which were derived from fragments of streptococcal prot...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 2020-01, Vol.60 (1), p.391-415
Hauptverfasser:	Gebauer, Michaela, Skerra, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adnectin Affibody antibody Anticalin DARPin immunoglobulin Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology Toxicology
Online-Zugang:	Volltext
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