Safety, Pharmacokinetics, and Mosquito‐Lethal Effects of Ivermectin in Combination With Dihydroartemisinin‐Piperaquine and Primaquine in Healthy Adult Thai Subjects

Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics, and mosquito‐lethal effects of combinations of ivermectin, dihydroartemisinin‐piperaquine, and primaquine were evaluated. Coadmi...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2020-05, Vol.107 (5), p.1221-1230
Hauptverfasser:	Kobylinski, Kevin C., Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Pantuwatana, Kanchana, Phasomkusolsil, Siriporn, Davidson, Silas A., Winterberg, Markus, Hoglund, Richard M., Mukaka, Mavuto, Pluijm, Rob W., Dondorp, Arjen, Day, Nicholas P.J., White, Nicholas J., Tarning, Joel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Anopheles - drug effects Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacokinetics Artemisinins - administration & dosage Artemisinins - adverse effects Artemisinins - pharmacokinetics Drug Interactions Drug Therapy, Combination Female Humans Insecticides - administration & dosage Insecticides - adverse effects Insecticides - pharmacokinetics Ivermectin - administration & dosage Ivermectin - adverse effects Ivermectin - pharmacokinetics Life Sciences & Biomedicine Malaria - prevention & control Male Middle Aged Pharmacology & Pharmacy Primaquine - administration & dosage Primaquine - adverse effects Primaquine - pharmacokinetics Quinolines - administration & dosage Quinolines - adverse effects Quinolines - pharmacokinetics Science & Technology Thailand Young Adult
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