Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders
NINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associat...
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| Veröffentlicht in: | Journal of molecular neuroscience 2020-02, Vol.70 (2), p.236-245 |
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| creator | Sayad, Arezou Ghafouri-Fard, Soudeh Omrani, Mir Davood Taheri, Mohammad |
| description | NINJ2
encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While the
NINJ2
rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs3809263 in a large cohort of neuropsychiatric patients including major depressive disorder, bipolar disorder, schizophrenia, and methamphetamine addiction. No significant difference was detected in frequencies of alleles, genotypes, or haplotypes between patients and controls. Thus, the current investigation failed to show association between rs11833579 and rs3809263 and the mentioned neuropsychiatric disorders. Future studies are needed to verify our results. |
| doi_str_mv | 10.1007/s12031-019-01462-1 |
| format | Article |
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encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While the
NINJ2
rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs3809263 in a large cohort of neuropsychiatric patients including major depressive disorder, bipolar disorder, schizophrenia, and methamphetamine addiction. No significant difference was detected in frequencies of alleles, genotypes, or haplotypes between patients and controls. Thus, the current investigation failed to show association between rs11833579 and rs3809263 and the mentioned neuropsychiatric disorders. Future studies are needed to verify our results.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-019-01462-1</identifier><identifier>PMID: 31873837</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Addictions ; Alzheimer's disease ; Biochemistry & Molecular Biology ; Biomedical and Life Sciences ; Biomedicine ; Bipolar disorder ; Cell Biology ; Disorders ; Diuretics ; Drug abuse ; Gene frequency ; Genotypes ; Haplotypes ; Health risks ; Ischemia ; Life Sciences & Biomedicine ; Mental depression ; Mental disorders ; Methamphetamine ; Multiple sclerosis ; Neurochemistry ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Neurosciences & Neurology ; Nucleotides ; Population ; Proteomics ; Regeneration ; Risk ; Schizophrenia ; Science & Technology ; Single-nucleotide polymorphism ; Stroke</subject><ispartof>Journal of molecular neuroscience, 2020-02, Vol.70 (2), p.236-245</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Journal of Molecular Neuroscience is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>6</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000504160700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-7a9d1bcf3811be3ca418776318c2f839d97029c36f6dd0500ddda26dd62de3ad3</citedby><cites>FETCH-LOGICAL-c375t-7a9d1bcf3811be3ca418776318c2f839d97029c36f6dd0500ddda26dd62de3ad3</cites><orcidid>0000-0001-8381-0591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-019-01462-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-019-01462-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,28255,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31873837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayad, Arezou</creatorcontrib><creatorcontrib>Ghafouri-Fard, Soudeh</creatorcontrib><creatorcontrib>Omrani, Mir Davood</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><title>Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J MOL NEUROSCI</addtitle><addtitle>J Mol Neurosci</addtitle><description>NINJ2
encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While the
NINJ2
rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs3809263 in a large cohort of neuropsychiatric patients including major depressive disorder, bipolar disorder, schizophrenia, and methamphetamine addiction. No significant difference was detected in frequencies of alleles, genotypes, or haplotypes between patients and controls. Thus, the current investigation failed to show association between rs11833579 and rs3809263 and the mentioned neuropsychiatric disorders. Future studies are needed to verify our results.</description><subject>Addictions</subject><subject>Alzheimer's disease</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bipolar disorder</subject><subject>Cell Biology</subject><subject>Disorders</subject><subject>Diuretics</subject><subject>Drug abuse</subject><subject>Gene frequency</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Health risks</subject><subject>Ischemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Methamphetamine</subject><subject>Multiple sclerosis</subject><subject>Neurochemistry</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Nucleotides</subject><subject>Population</subject><subject>Proteomics</subject><subject>Regeneration</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Science & Technology</subject><subject>Single-nucleotide polymorphism</subject><subject>Stroke</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUFv1DAQhS0EotvCH-CALHFBQmnH9sZJjmWBUlQtFZRzlLUnXZfEXjyJVvvv623aInGoOFiew_ee3sxj7I2AYwFQnJCQoEQGokpvrmUmnrGZyPMqE0Lr52wGZZVnpa70ATskugGQYi7Kl-xAibJQpSpmbH1KFIxrBhc88Y84bBE9v9oG_tP56w6z5Wg6DIOzyC9Dt-tD3Kwd9cSd58vz5TfJz9Ajb7zlPxz95qHll7Qz62QZneGfHIVoMdIr9qJtOsLX9_8R-_Xl89Xia3bx_ex8cXqRGVXkQ1Y0lRUr06pSiBUq06TARaFTYCPbUlW2KkBWRulWWws5gLW2kWnW0qJqrDpi7yffTQx_RqSh7h0Z7LrGYxiplkqBklqDTui7f9CbMEaf0iUqn2uoZCkSJSfKxEAUsa030fVN3NUC6n0P9dRDnXqo73qo96K399bjqkf7KHk4fAI-TMAWV6El49AbfMQA0mpzoaFIE-ztyv-nF264q3MRRj8kqZqklHB_jfHvkk_kvwVsvLMt</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Sayad, Arezou</creator><creator>Ghafouri-Fard, Soudeh</creator><creator>Omrani, Mir Davood</creator><creator>Taheri, Mohammad</creator><general>Springer US</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></search><sort><creationdate>20200201</creationdate><title>Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders</title><author>Sayad, Arezou ; Ghafouri-Fard, Soudeh ; Omrani, Mir Davood ; Taheri, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7a9d1bcf3811be3ca418776318c2f839d97029c36f6dd0500ddda26dd62de3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Addictions</topic><topic>Alzheimer's disease</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bipolar disorder</topic><topic>Cell Biology</topic><topic>Disorders</topic><topic>Diuretics</topic><topic>Drug abuse</topic><topic>Gene frequency</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Health risks</topic><topic>Ischemia</topic><topic>Life Sciences & Biomedicine</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Methamphetamine</topic><topic>Multiple sclerosis</topic><topic>Neurochemistry</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Nucleotides</topic><topic>Population</topic><topic>Proteomics</topic><topic>Regeneration</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Science & Technology</topic><topic>Single-nucleotide polymorphism</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayad, Arezou</creatorcontrib><creatorcontrib>Ghafouri-Fard, Soudeh</creatorcontrib><creatorcontrib>Omrani, Mir Davood</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sayad, Arezou</au><au>Ghafouri-Fard, Soudeh</au><au>Omrani, Mir Davood</au><au>Taheri, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><stitle>J MOL NEUROSCI</stitle><addtitle>J Mol Neurosci</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>70</volume><issue>2</issue><spage>236</spage><epage>245</epage><pages>236-245</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>NINJ2
encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While the
NINJ2
rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs3809263 in a large cohort of neuropsychiatric patients including major depressive disorder, bipolar disorder, schizophrenia, and methamphetamine addiction. No significant difference was detected in frequencies of alleles, genotypes, or haplotypes between patients and controls. Thus, the current investigation failed to show association between rs11833579 and rs3809263 and the mentioned neuropsychiatric disorders. Future studies are needed to verify our results.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31873837</pmid><doi>10.1007/s12031-019-01462-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></addata></record> |
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| subjects | Addictions Alzheimer's disease Biochemistry & Molecular Biology Biomedical and Life Sciences Biomedicine Bipolar disorder Cell Biology Disorders Diuretics Drug abuse Gene frequency Genotypes Haplotypes Health risks Ischemia Life Sciences & Biomedicine Mental depression Mental disorders Methamphetamine Multiple sclerosis Neurochemistry Neurodegenerative diseases Neurology Neurosciences Neurosciences & Neurology Nucleotides Population Proteomics Regeneration Risk Schizophrenia Science & Technology Single-nucleotide polymorphism Stroke |
| title | Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders |
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