Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice
In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced...
Gespeichert in:
| Veröffentlicht in: | Food science and biotechnology 2020, 29(2), , pp.275-281 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 281 |
|---|---|
| container_issue | 2 |
| container_start_page | 275 |
| container_title | Food science and biotechnology |
| container_volume | 29 |
| creator | Kim, Hwa-Jin You, Mi-Kyoung Wang, Ziyun Lee, Young-Hyeon Kim, Hyeon-A |
| description | In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases. |
| doi_str_mv | 10.1007/s10068-019-00710-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000500312200001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2356605577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c574t-61c1c77a93b425975bcba41452ccf08a7075145a4bcb5d249744fca0ff0a53d03</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhD3BAkbiAkOnY8UdyQSorPiqthFQVrpbjOLtud53Udij99wybsnwcEBd7xn7e0YxfF8VTCq8pgDpJuMqaAG0IphRIc69YMGgYkVzI-8WCMiaJUlAfFY9SukSaMsUfFkcVA8lpJRfFl3PXlaMbRxfL5DC-MRlD9y1HY3OZpnGMLiWXyo1fb0hvctl5l4kP3WQRH1qXfL4tfSiXQr1dnchy5617XDzozTa5J3f7cfH5_buL5Uey-vThbHm6IlYonomkllqlTFO1nIlGida2hlMumLU91EaBEpgZjueiY7xRnPfWQN-DEVUH1XHxcq4bYq-vrNeD8ft9PeirqE_PL860lA3jlUD2zcyOU7tznXUBZ9zqMfqdibd75Z83wW-wzlctm4bVFccCL-4KxOF6cinrnU_WbbcmuGFKmlVCShBCKUSf_4VeDlMM-BRI8boWUCuGFJspG4eUousPzVDQPyzWs8UaLdZ7i3WDome_j3GQ_PQUgVczcOPaoU_Wu2DdAQMAAVDh18AIKNL1_9NLn032Q1gOU8gorWZpQjysXfw15D_6_w4GPtCh</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2348850872</pqid></control><display><type>article</type><title>Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice</title><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kim, Hwa-Jin ; You, Mi-Kyoung ; Wang, Ziyun ; Lee, Young-Hyeon ; Kim, Hyeon-A</creator><creatorcontrib>Kim, Hwa-Jin ; You, Mi-Kyoung ; Wang, Ziyun ; Lee, Young-Hyeon ; Kim, Hyeon-A</creatorcontrib><description>In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.</description><identifier>ISSN: 1226-7708</identifier><identifier>EISSN: 2092-6456</identifier><identifier>DOI: 10.1007/s10068-019-00710-9</identifier><identifier>PMID: 32064136</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adipose tissue ; AMP-activated protein kinase ; Body fat ; Body weight ; Chemistry ; Chemistry and Materials Science ; Diet ; Dual energy X-ray absorptiometry ; Food Science ; Food Science & Technology ; Gene expression ; High fat diet ; Homeostasis ; Hyperlipidemia ; Insulin ; Kinases ; Life Sciences & Biomedicine ; Nutrition ; Obesity ; Science & Technology ; Transcription activation ; Transcription factors ; 식품과학</subject><ispartof>Food Science and Biotechnology, 2020, 29(2), , pp.275-281</ispartof><rights>The Korean Society of Food Science and Technology 2019</rights><rights>The Korean Society of Food Science and Technology 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000500312200001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c574t-61c1c77a93b425975bcba41452ccf08a7075145a4bcb5d249744fca0ff0a53d03</citedby><cites>FETCH-LOGICAL-c574t-61c1c77a93b425975bcba41452ccf08a7075145a4bcb5d249744fca0ff0a53d03</cites><orcidid>0000-0002-9280-4828 ; 0000-0002-0908-113X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992834/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992834/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,28255,41495,42564,51326,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32064136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002556049$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hwa-Jin</creatorcontrib><creatorcontrib>You, Mi-Kyoung</creatorcontrib><creatorcontrib>Wang, Ziyun</creatorcontrib><creatorcontrib>Lee, Young-Hyeon</creatorcontrib><creatorcontrib>Kim, Hyeon-A</creatorcontrib><title>Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice</title><title>Food science and biotechnology</title><addtitle>Food Sci Biotechnol</addtitle><addtitle>FOOD SCI BIOTECHNOL</addtitle><addtitle>Food Sci Biotechnol</addtitle><description>In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.</description><subject>Adipose tissue</subject><subject>AMP-activated protein kinase</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diet</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Food Science</subject><subject>Food Science & Technology</subject><subject>Gene expression</subject><subject>High fat diet</subject><subject>Homeostasis</subject><subject>Hyperlipidemia</subject><subject>Insulin</subject><subject>Kinases</subject><subject>Life Sciences & Biomedicine</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Science & Technology</subject><subject>Transcription activation</subject><subject>Transcription factors</subject><subject>식품과학</subject><issn>1226-7708</issn><issn>2092-6456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkk1v1DAQhiMEokvhD3BAkbiAkOnY8UdyQSorPiqthFQVrpbjOLtud53Udij99wybsnwcEBd7xn7e0YxfF8VTCq8pgDpJuMqaAG0IphRIc69YMGgYkVzI-8WCMiaJUlAfFY9SukSaMsUfFkcVA8lpJRfFl3PXlaMbRxfL5DC-MRlD9y1HY3OZpnGMLiWXyo1fb0hvctl5l4kP3WQRH1qXfL4tfSiXQr1dnchy5617XDzozTa5J3f7cfH5_buL5Uey-vThbHm6IlYonomkllqlTFO1nIlGida2hlMumLU91EaBEpgZjueiY7xRnPfWQN-DEVUH1XHxcq4bYq-vrNeD8ft9PeirqE_PL860lA3jlUD2zcyOU7tznXUBZ9zqMfqdibd75Z83wW-wzlctm4bVFccCL-4KxOF6cinrnU_WbbcmuGFKmlVCShBCKUSf_4VeDlMM-BRI8boWUCuGFJspG4eUousPzVDQPyzWs8UaLdZ7i3WDome_j3GQ_PQUgVczcOPaoU_Wu2DdAQMAAVDh18AIKNL1_9NLn032Q1gOU8gorWZpQjysXfw15D_6_w4GPtCh</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Kim, Hwa-Jin</creator><creator>You, Mi-Kyoung</creator><creator>Wang, Ziyun</creator><creator>Lee, Young-Hyeon</creator><creator>Kim, Hyeon-A</creator><general>Springer Singapore</general><general>Korean Society Food Science & Technology-Kosfost</general><general>Springer Nature B.V</general><general>한국식품과학회</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-9280-4828</orcidid><orcidid>https://orcid.org/0000-0002-0908-113X</orcidid></search><sort><creationdate>20200201</creationdate><title>Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice</title><author>Kim, Hwa-Jin ; You, Mi-Kyoung ; Wang, Ziyun ; Lee, Young-Hyeon ; Kim, Hyeon-A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-61c1c77a93b425975bcba41452ccf08a7075145a4bcb5d249744fca0ff0a53d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>AMP-activated protein kinase</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diet</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Food Science</topic><topic>Food Science & Technology</topic><topic>Gene expression</topic><topic>High fat diet</topic><topic>Homeostasis</topic><topic>Hyperlipidemia</topic><topic>Insulin</topic><topic>Kinases</topic><topic>Life Sciences & Biomedicine</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Science & Technology</topic><topic>Transcription activation</topic><topic>Transcription factors</topic><topic>식품과학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hwa-Jin</creatorcontrib><creatorcontrib>You, Mi-Kyoung</creatorcontrib><creatorcontrib>Wang, Ziyun</creatorcontrib><creatorcontrib>Lee, Young-Hyeon</creatorcontrib><creatorcontrib>Kim, Hyeon-A</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Food science and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hwa-Jin</au><au>You, Mi-Kyoung</au><au>Wang, Ziyun</au><au>Lee, Young-Hyeon</au><au>Kim, Hyeon-A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice</atitle><jtitle>Food science and biotechnology</jtitle><stitle>Food Sci Biotechnol</stitle><stitle>FOOD SCI BIOTECHNOL</stitle><addtitle>Food Sci Biotechnol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>29</volume><issue>2</issue><spage>275</spage><epage>281</epage><pages>275-281</pages><issn>1226-7708</issn><eissn>2092-6456</eissn><abstract>In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32064136</pmid><doi>10.1007/s10068-019-00710-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9280-4828</orcidid><orcidid>https://orcid.org/0000-0002-0908-113X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1226-7708 |
| ispartof | Food Science and Biotechnology, 2020, 29(2), , pp.275-281 |
| issn | 1226-7708 2092-6456 |
| language | eng |
| recordid | cdi_webofscience_primary_000500312200001 |
| source | SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipose tissue AMP-activated protein kinase Body fat Body weight Chemistry Chemistry and Materials Science Diet Dual energy X-ray absorptiometry Food Science Food Science & Technology Gene expression High fat diet Homeostasis Hyperlipidemia Insulin Kinases Life Sciences & Biomedicine Nutrition Obesity Science & Technology Transcription activation Transcription factors 식품과학 |
| title | Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T17%3A10%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Red%20pepper%20seed%20water%20extract%20suppresses%20high-fat%20diet-induced%20obesity%20in%20C57BL/6%20mice&rft.jtitle=Food%20science%20and%20biotechnology&rft.au=Kim,%20Hwa-Jin&rft.date=2020-02-01&rft.volume=29&rft.issue=2&rft.spage=275&rft.epage=281&rft.pages=275-281&rft.issn=1226-7708&rft.eissn=2092-6456&rft_id=info:doi/10.1007/s10068-019-00710-9&rft_dat=%3Cproquest_webof%3E2356605577%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2348850872&rft_id=info:pmid/32064136&rfr_iscdi=true |