Cancer‐associated fibroblasts promote malignancy of gastric cancer cells via Nodal signalling

The roles of cancer‐associated fibroblasts (CAFs) in progression of gastric cancer (GC) are far from well illustration. Here, we show that CAFs can trigger the proliferation and decrease the doxorubicin (Dox) sensitivity of GC cells via secretion of Nodal, one embryonic morphogen that can promote ma...

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Veröffentlicht in:	Cell biochemistry and function 2020-01, Vol.38 (1), p.4-11
Hauptverfasser:	Pang, Tao, Yin, Xiaoyi, Luo, Tianhang, Lu, Zhengmao, Nie, Mingming, Yin, Kai, Xue, Xuchao
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibiotics, Antineoplastic - pharmacology Antibodies Biochemistry & Molecular Biology CAF Cancer Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology castric cancer Cell activation Cell Biology Cell proliferation Cell Proliferation - drug effects Dose-Response Relationship, Drug Doxorubicin Doxorubicin - pharmacology Embryos Fibroblasts Gastric cancer Humans Life Sciences & Biomedicine Localization Malignancy Neutralization Nodal Nodal Protein - antagonists & inhibitors Nodal Protein - genetics Nodal Protein - metabolism Phosphorylation proliferation Science & Technology Sensitivity Signal Transduction - drug effects Smad2 protein Smad2/3 Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Structure-Activity Relationship Tumor Cells, Cultured
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