In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products
Antitumor and immunotropic effects of κ‐, λ‐carrageenan from red marine algae Chondrus armatus and their low‐molecular weight (LMW) degradation products were explored. Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro‐ and anti‐inflammato...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2020-02, Vol.108 (2), p.254-266 |
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| container_title | Journal of biomedical materials research. Part A |
| container_volume | 108 |
| creator | Cicinskas, Eduardas Begun, Maria A. Tiasto, Vladlena A. Belousov, Andrei S. Vikhareva, Valeria V. Mikhailova, Valeria A. Kalitnik, Alexandra A. |
| description | Antitumor and immunotropic effects of κ‐, λ‐carrageenan from red marine algae Chondrus armatus and their low‐molecular weight (LMW) degradation products were explored. Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro‐ and anti‐inflammatory cytokines by human monocytes was assessed. All polysaccharides demonstrated antimetabolic and cytostatic activity towards cancer lines, with high‐molecular weight carrageenans possessing higher antimetabolic and lower cytostatic activity than their LMW degradation products. All carrageenans induced monocytes to produce pro‐inflammatory cytokines IL1β, IL6, IL18, and TNFα. However, secretion of anti‐inflammatory cytokine IL10 was induced only by LMW λ‐carrageenan, which exhibited the highest cytokine production inducing efficacy overall. We demonstrate that LMW carrageenan degradation products not only retain biological activity of their precursors, but also increase their efficacy in type‐dependent manner, allowing for their future development for pharmacological practice. |
| doi_str_mv | 10.1002/jbm.a.36812 |
| format | Article |
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Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro‐ and anti‐inflammatory cytokines by human monocytes was assessed. All polysaccharides demonstrated antimetabolic and cytostatic activity towards cancer lines, with high‐molecular weight carrageenans possessing higher antimetabolic and lower cytostatic activity than their LMW degradation products. All carrageenans induced monocytes to produce pro‐inflammatory cytokines IL1β, IL6, IL18, and TNFα. However, secretion of anti‐inflammatory cytokine IL10 was induced only by LMW λ‐carrageenan, which exhibited the highest cytokine production inducing efficacy overall. We demonstrate that LMW carrageenan degradation products not only retain biological activity of their precursors, but also increase their efficacy in type‐dependent manner, allowing for their future development for pharmacological practice.</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.36812</identifier><identifier>PMID: 31606930</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Algae ; Anticancer properties ; Antitumor activity ; Biological activity ; Cancer ; Carrageenan ; Carrageenans ; Chondrus ; Chondrus armatus ; Cytokines ; Degradation ; Degradation products ; Engineering ; Engineering, Biomedical ; Esophagus ; immunotropic activity ; Inflammation ; Interleukin 1 ; Interleukin 10 ; Interleukin 18 ; Interleukin 6 ; Ions ; Materials Science ; Materials Science, Biomaterials ; Molecular weight ; Monocytes ; Polysaccharides ; Saccharides ; Science & Technology ; Technology ; Tumor cell lines ; Tumor necrosis factor-α ; Viability</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J BIOMED MATER RES A</addtitle><addtitle>J Biomed Mater Res A</addtitle><description>Antitumor and immunotropic effects of κ‐, λ‐carrageenan from red marine algae Chondrus armatus and their low‐molecular weight (LMW) degradation products were explored. Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro‐ and anti‐inflammatory cytokines by human monocytes was assessed. All polysaccharides demonstrated antimetabolic and cytostatic activity towards cancer lines, with high‐molecular weight carrageenans possessing higher antimetabolic and lower cytostatic activity than their LMW degradation products. All carrageenans induced monocytes to produce pro‐inflammatory cytokines IL1β, IL6, IL18, and TNFα. However, secretion of anti‐inflammatory cytokine IL10 was induced only by LMW λ‐carrageenan, which exhibited the highest cytokine production inducing efficacy overall. We demonstrate that LMW carrageenan degradation products not only retain biological activity of their precursors, but also increase their efficacy in type‐dependent manner, allowing for their future development for pharmacological practice.</description><subject>Algae</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Biological activity</subject><subject>Cancer</subject><subject>Carrageenan</subject><subject>Carrageenans</subject><subject>Chondrus</subject><subject>Chondrus armatus</subject><subject>Cytokines</subject><subject>Degradation</subject><subject>Degradation products</subject><subject>Engineering</subject><subject>Engineering, Biomedical</subject><subject>Esophagus</subject><subject>immunotropic activity</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 18</subject><subject>Interleukin 6</subject><subject>Ions</subject><subject>Materials Science</subject><subject>Materials Science, Biomaterials</subject><subject>Molecular weight</subject><subject>Monocytes</subject><subject>Polysaccharides</subject><subject>Saccharides</subject><subject>Science & Technology</subject><subject>Technology</subject><subject>Tumor cell lines</subject><subject>Tumor necrosis factor-α</subject><subject>Viability</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkUuLFDEUhQtRnHF05V4CbgSpNo9KPZYzhY-RETe6Lm4lt7rTVCVtkrLpnT9B_In-ElPT7QguxNU9hO-eHO7JsqeMrhil_NW2n1awEmXN-L3snEnJ86Ip5f1FF00ueFOeZY9C2Ca4pJI_zM4EK2nZCHqe_bi25KuJ3hGw0cR5cj4pTcw0zdal951RBFQ0CToQNxAF3sMa0YINZPBuIh41gXENSNqNs9rPgYCfIC4zOcUNGk9Gt__57fvkRlTzCJ7s0aw3kWhce9AQjbNk552eVQyPswcDjAGfnOZF9vnN60_tu_zm49vr9vImV6KkPIdKyFLzWjGsQAou66ZH6NVQgVCy4boQekAoh4KxWiGHQSuBQJsGkQ2SiYvsxdE3ffxlxhC7yQSF4wgW3Rw6LqgsqqrhC_r8L3TrZm9TukRxXnJaSZGol0dKeReCx6HbeTOBP3SMdktVXaqqg-62qkQ_O3nO_YT6jv3dzR-7PfZuCMqgVXiHUUqLpmB1JZKiS8T6_-nWxNubt262Ma3y06oZ8fCv0N37qw-Xx_i_AGBcxFA</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Cicinskas, Eduardas</creator><creator>Begun, Maria A.</creator><creator>Tiasto, Vladlena A.</creator><creator>Belousov, Andrei S.</creator><creator>Vikhareva, Valeria V.</creator><creator>Mikhailova, Valeria A.</creator><creator>Kalitnik, Alexandra A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5120-2946</orcidid><orcidid>https://orcid.org/0000-0001-6030-2543</orcidid><orcidid>https://orcid.org/0000-0001-8257-3109</orcidid></search><sort><creationdate>202002</creationdate><title>In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products</title><author>Cicinskas, Eduardas ; 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Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cicinskas, Eduardas</au><au>Begun, Maria A.</au><au>Tiasto, Vladlena A.</au><au>Belousov, Andrei S.</au><au>Vikhareva, Valeria V.</au><au>Mikhailova, Valeria A.</au><au>Kalitnik, Alexandra A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><stitle>J BIOMED MATER RES A</stitle><addtitle>J Biomed Mater Res A</addtitle><date>2020-02</date><risdate>2020</risdate><volume>108</volume><issue>2</issue><spage>254</spage><epage>266</epage><pages>254-266</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>Antitumor and immunotropic effects of κ‐, λ‐carrageenan from red marine algae Chondrus armatus and their low‐molecular weight (LMW) degradation products were explored. Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro‐ and anti‐inflammatory cytokines by human monocytes was assessed. All polysaccharides demonstrated antimetabolic and cytostatic activity towards cancer lines, with high‐molecular weight carrageenans possessing higher antimetabolic and lower cytostatic activity than their LMW degradation products. All carrageenans induced monocytes to produce pro‐inflammatory cytokines IL1β, IL6, IL18, and TNFα. However, secretion of anti‐inflammatory cytokine IL10 was induced only by LMW λ‐carrageenan, which exhibited the highest cytokine production inducing efficacy overall. We demonstrate that LMW carrageenan degradation products not only retain biological activity of their precursors, but also increase their efficacy in type‐dependent manner, allowing for their future development for pharmacological practice.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31606930</pmid><doi>10.1002/jbm.a.36812</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5120-2946</orcidid><orcidid>https://orcid.org/0000-0001-6030-2543</orcidid><orcidid>https://orcid.org/0000-0001-8257-3109</orcidid></addata></record> |
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| subjects | Algae Anticancer properties Antitumor activity Biological activity Cancer Carrageenan Carrageenans Chondrus Chondrus armatus Cytokines Degradation Degradation products Engineering Engineering, Biomedical Esophagus immunotropic activity Inflammation Interleukin 1 Interleukin 10 Interleukin 18 Interleukin 6 Ions Materials Science Materials Science, Biomaterials Molecular weight Monocytes Polysaccharides Saccharides Science & Technology Technology Tumor cell lines Tumor necrosis factor-α Viability |
| title | In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products |
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