Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects
Purpose To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects. Patients and methods A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The...
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| Veröffentlicht in: | International ophthalmology 2020-02, Vol.40 (2), p.419-422 |
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| creator | Carracedo-Rodríguez, Gonzalo Martínez-Águila, Alejandro Rodriguez-Pomar, Candela Bodas-Romero, Julia Sanchez-Naves, Juan Pintor, Jesús |
| description | Purpose
To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.
Patients and methods
A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (
n
= 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (
n
= 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.
Results
The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (
p
value |
| doi_str_mv | 10.1007/s10792-019-01199-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000492335600001CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2360705499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-c394b84aa533b6e56f99e6f3b47407c34aced956667e1b6b956c1193262b37963</originalsourceid><addsrcrecordid>eNqNkE1vFSEUhomxsdfqH3BhSFyasTB8laW5qR9JEzftmgD3jJ2bGRiB0fjvPdepdWdcEM6B5z3wvoS84uwdZ8xcVs6M7TvGLS5ubcefkB1XRnS9Fuwp2TGuVacM4-fkea1Hxpg1Vj8j5wIvmFByR-6vhwFio3mgaW1lbGNOfqJ1XZYJZkiNBl_hQHOiM0y-5TSmU9PugY6pFZ_jOvlClwK1ruV0SFMuc26Q6vgdcFI44gP1BTkb_FTh5cN-Qe4-XN_uP3U3Xz5-3r-_6aLktnVRWBmupPdKiKBB6cFa0IMI0khmopA-wsEqrbUBHnTAMqJ30es-CDQnLsibbe5S8rcVanPHvBb0VF0vNDNMSWuR6jcqllxrgcEtZZx9-ek4c6dw3Rauw3Dd73AdR9Hrh9FrmOHwKPmTJgJXG_ADQh5qHCFFeMQwfml7IZTGivH92Pwp7X1eU0Pp2_-XIi02uiKRvkL5a_If__8F3kumiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2360705499</pqid></control><display><type>article</type><title>Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Carracedo-Rodríguez, Gonzalo ; Martínez-Águila, Alejandro ; Rodriguez-Pomar, Candela ; Bodas-Romero, Julia ; Sanchez-Naves, Juan ; Pintor, Jesús</creator><creatorcontrib>Carracedo-Rodríguez, Gonzalo ; Martínez-Águila, Alejandro ; Rodriguez-Pomar, Candela ; Bodas-Romero, Julia ; Sanchez-Naves, Juan ; Pintor, Jesús</creatorcontrib><description>Purpose
To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.
Patients and methods
A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (
n
= 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (
n
= 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.
Results
The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (
p
value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (
p
value < 0.001).
Conclusion
The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-019-01199-1</identifier><identifier>PMID: 31650354</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Antioxidants - administration & dosage ; Dietary supplements ; Experiments ; Female ; Follow-Up Studies ; Healthy Volunteers ; Humans ; Intraocular pressure ; Intraocular Pressure - drug effects ; Intraocular Pressure - physiology ; Life Sciences & Biomedicine ; Male ; Medicine ; Medicine & Public Health ; Melatonin ; Melatonin - pharmacology ; Mercury ; Middle Aged ; Nutritional Support - methods ; Ocular Hypertension - drug therapy ; Ocular Hypertension - physiopathology ; Ophthalmology ; Original Paper ; Pressure ; Prospective Studies ; Reduction ; Science & Technology ; Statistical analysis ; Tonometry, Ocular ; Young Adult</subject><ispartof>International ophthalmology, 2020-02, Vol.40 (2), p.419-422</ispartof><rights>Springer Nature B.V. 2019</rights><rights>International Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000492335600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c419t-c394b84aa533b6e56f99e6f3b47407c34aced956667e1b6b956c1193262b37963</citedby><cites>FETCH-LOGICAL-c419t-c394b84aa533b6e56f99e6f3b47407c34aced956667e1b6b956c1193262b37963</cites><orcidid>0000-0003-0054-1731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-019-01199-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-019-01199-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,28253,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31650354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carracedo-Rodríguez, Gonzalo</creatorcontrib><creatorcontrib>Martínez-Águila, Alejandro</creatorcontrib><creatorcontrib>Rodriguez-Pomar, Candela</creatorcontrib><creatorcontrib>Bodas-Romero, Julia</creatorcontrib><creatorcontrib>Sanchez-Naves, Juan</creatorcontrib><creatorcontrib>Pintor, Jesús</creatorcontrib><title>Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>INT OPHTHALMOL</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.
Patients and methods
A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (
n
= 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (
n
= 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.
Results
The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (
p
value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (
p
value < 0.001).
Conclusion
The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.</description><subject>Adult</subject><subject>Antioxidants - administration & dosage</subject><subject>Dietary supplements</subject><subject>Experiments</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Intraocular pressure</subject><subject>Intraocular Pressure - drug effects</subject><subject>Intraocular Pressure - physiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Mercury</subject><subject>Middle Aged</subject><subject>Nutritional Support - methods</subject><subject>Ocular Hypertension - drug therapy</subject><subject>Ocular Hypertension - physiopathology</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Pressure</subject><subject>Prospective Studies</subject><subject>Reduction</subject><subject>Science & Technology</subject><subject>Statistical analysis</subject><subject>Tonometry, Ocular</subject><subject>Young Adult</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkE1vFSEUhomxsdfqH3BhSFyasTB8laW5qR9JEzftmgD3jJ2bGRiB0fjvPdepdWdcEM6B5z3wvoS84uwdZ8xcVs6M7TvGLS5ubcefkB1XRnS9Fuwp2TGuVacM4-fkea1Hxpg1Vj8j5wIvmFByR-6vhwFio3mgaW1lbGNOfqJ1XZYJZkiNBl_hQHOiM0y-5TSmU9PugY6pFZ_jOvlClwK1ruV0SFMuc26Q6vgdcFI44gP1BTkb_FTh5cN-Qe4-XN_uP3U3Xz5-3r-_6aLktnVRWBmupPdKiKBB6cFa0IMI0khmopA-wsEqrbUBHnTAMqJ30es-CDQnLsibbe5S8rcVanPHvBb0VF0vNDNMSWuR6jcqllxrgcEtZZx9-ek4c6dw3Rauw3Dd73AdR9Hrh9FrmOHwKPmTJgJXG_ADQh5qHCFFeMQwfml7IZTGivH92Pwp7X1eU0Pp2_-XIi02uiKRvkL5a_If__8F3kumiQ</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Carracedo-Rodríguez, Gonzalo</creator><creator>Martínez-Águila, Alejandro</creator><creator>Rodriguez-Pomar, Candela</creator><creator>Bodas-Romero, Julia</creator><creator>Sanchez-Naves, Juan</creator><creator>Pintor, Jesús</creator><general>Springer Netherlands</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0054-1731</orcidid></search><sort><creationdate>20200201</creationdate><title>Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects</title><author>Carracedo-Rodríguez, Gonzalo ; Martínez-Águila, Alejandro ; Rodriguez-Pomar, Candela ; Bodas-Romero, Julia ; Sanchez-Naves, Juan ; Pintor, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c394b84aa533b6e56f99e6f3b47407c34aced956667e1b6b956c1193262b37963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Antioxidants - administration & dosage</topic><topic>Dietary supplements</topic><topic>Experiments</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Intraocular pressure</topic><topic>Intraocular Pressure - drug effects</topic><topic>Intraocular Pressure - physiology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Mercury</topic><topic>Middle Aged</topic><topic>Nutritional Support - methods</topic><topic>Ocular Hypertension - drug therapy</topic><topic>Ocular Hypertension - physiopathology</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Pressure</topic><topic>Prospective Studies</topic><topic>Reduction</topic><topic>Science & Technology</topic><topic>Statistical analysis</topic><topic>Tonometry, Ocular</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carracedo-Rodríguez, Gonzalo</creatorcontrib><creatorcontrib>Martínez-Águila, Alejandro</creatorcontrib><creatorcontrib>Rodriguez-Pomar, Candela</creatorcontrib><creatorcontrib>Bodas-Romero, Julia</creatorcontrib><creatorcontrib>Sanchez-Naves, Juan</creatorcontrib><creatorcontrib>Pintor, Jesús</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carracedo-Rodríguez, Gonzalo</au><au>Martínez-Águila, Alejandro</au><au>Rodriguez-Pomar, Candela</au><au>Bodas-Romero, Julia</au><au>Sanchez-Naves, Juan</au><au>Pintor, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><stitle>INT OPHTHALMOL</stitle><addtitle>Int Ophthalmol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>40</volume><issue>2</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.
Patients and methods
A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (
n
= 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (
n
= 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.
Results
The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (
p
value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (
p
value < 0.001).
Conclusion
The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31650354</pmid><doi>10.1007/s10792-019-01199-1</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-0054-1731</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antioxidants - administration & dosage Dietary supplements Experiments Female Follow-Up Studies Healthy Volunteers Humans Intraocular pressure Intraocular Pressure - drug effects Intraocular Pressure - physiology Life Sciences & Biomedicine Male Medicine Medicine & Public Health Melatonin Melatonin - pharmacology Mercury Middle Aged Nutritional Support - methods Ocular Hypertension - drug therapy Ocular Hypertension - physiopathology Ophthalmology Original Paper Pressure Prospective Studies Reduction Science & Technology Statistical analysis Tonometry, Ocular Young Adult |
| title | Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects |
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