Nontyphoidal Salmonella: a potential anticancer agent
Summary Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely...
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| Veröffentlicht in: | Journal of applied microbiology 2020-01, Vol.128 (1), p.2-14 |
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| container_title | Journal of applied microbiology |
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| creator | Jazeela, K. Chakraborty, A. Karunasagar, I. Deekshit, V.K. |
| description | Summary
Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella. |
| doi_str_mv | 10.1111/jam.14297 |
| format | Article |
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Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.14297</identifier><identifier>PMID: 31038778</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; anticancer agents ; Anticancer properties ; Antineoplastic Agents - therapeutic use ; Bacteria ; bacteria‐mediated cancer therapy ; bactofection ; Cancer ; Humans ; Neoplasms - microbiology ; Neoplasms - therapy ; Salmonella ; Salmonella - growth & development ; Salmonella - physiology ; Salmonella typhimurium - growth & development ; Salmonella typhimurium - physiology ; Salmonella‐tumour interaction ; Semisolids ; Side effects ; Tumors</subject><ispartof>Journal of applied microbiology, 2020-01, Vol.128 (1), p.2-14</ispartof><rights>2019 The Society for Applied Microbiology</rights><rights>2019 The Society for Applied Microbiology.</rights><rights>Copyright © 2020 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-e2d75ac530516d684f8b8cf8a3ff385e2c3af7fa781ca8851e6ba4ea2d9141e3</citedby><cites>FETCH-LOGICAL-c3887-e2d75ac530516d684f8b8cf8a3ff385e2c3af7fa781ca8851e6ba4ea2d9141e3</cites><orcidid>0000-0002-3535-5528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.14297$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.14297$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31038778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jazeela, K.</creatorcontrib><creatorcontrib>Chakraborty, A.</creatorcontrib><creatorcontrib>Karunasagar, I.</creatorcontrib><creatorcontrib>Deekshit, V.K.</creatorcontrib><title>Nontyphoidal Salmonella: a potential anticancer agent</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Summary
Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella.</description><subject>Animals</subject><subject>anticancer agents</subject><subject>Anticancer properties</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Bacteria</subject><subject>bacteria‐mediated cancer therapy</subject><subject>bactofection</subject><subject>Cancer</subject><subject>Humans</subject><subject>Neoplasms - microbiology</subject><subject>Neoplasms - therapy</subject><subject>Salmonella</subject><subject>Salmonella - growth & development</subject><subject>Salmonella - physiology</subject><subject>Salmonella typhimurium - growth & development</subject><subject>Salmonella typhimurium - physiology</subject><subject>Salmonella‐tumour interaction</subject><subject>Semisolids</subject><subject>Side effects</subject><subject>Tumors</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiMEYmNw4A-gSlzg0C0fTZNxmyY-NeDA7pGXJtCpbUrTCu3fk62DAxL2wZb1-LX1InRO8JiEmKyhHJOETsUBGhKW8pimgh7u-iTmWNABOvF-jTFhmKfHaMAIZlIIOUT8xVXtpv5weQZF9AZF6SpTFHATQVS71lRtHuYQioZKmyaC9zA7RUcWCm_O9nWElne3y_lDvHi9f5zPFrFmUorY0Exw0DxcJWmWysTKldRWArOWSW6oZmCFBSGJBik5MekKEgM0m5KEGDZCV71s3bjPzvhWlbnX2_cq4zqvKCUiCWsCB_TyD7p2XVOF5xRlISmXkgTquqd047xvjFV1k5fQbBTBamulClaqnZWBvdgrdqvSZL_kj3cBmPTAV16Yzf9K6mn23Et-A6CwfAU</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Jazeela, K.</creator><creator>Chakraborty, A.</creator><creator>Karunasagar, I.</creator><creator>Deekshit, V.K.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3535-5528</orcidid></search><sort><creationdate>202001</creationdate><title>Nontyphoidal Salmonella: a potential anticancer agent</title><author>Jazeela, K. ; Chakraborty, A. ; Karunasagar, I. ; Deekshit, V.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-e2d75ac530516d684f8b8cf8a3ff385e2c3af7fa781ca8851e6ba4ea2d9141e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>anticancer agents</topic><topic>Anticancer properties</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Bacteria</topic><topic>bacteria‐mediated cancer therapy</topic><topic>bactofection</topic><topic>Cancer</topic><topic>Humans</topic><topic>Neoplasms - microbiology</topic><topic>Neoplasms - therapy</topic><topic>Salmonella</topic><topic>Salmonella - growth & development</topic><topic>Salmonella - physiology</topic><topic>Salmonella typhimurium - growth & development</topic><topic>Salmonella typhimurium - physiology</topic><topic>Salmonella‐tumour interaction</topic><topic>Semisolids</topic><topic>Side effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jazeela, K.</creatorcontrib><creatorcontrib>Chakraborty, A.</creatorcontrib><creatorcontrib>Karunasagar, I.</creatorcontrib><creatorcontrib>Deekshit, V.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jazeela, K.</au><au>Chakraborty, A.</au><au>Karunasagar, I.</au><au>Deekshit, V.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nontyphoidal Salmonella: a potential anticancer agent</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>128</volume><issue>1</issue><spage>2</spage><epage>14</epage><pages>2-14</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Summary
Use of bacteria in cancer therapy, despite being considered as a potent strategy, has not really picked up the way other methods of cancer therapies have evolved. However, in recent years, the interest on use of bacteria to kill cancer cells has renewed considerably. The standard and widely followed strategies of cancer treatment often fail either due to the complexity of tumour biology or because of the accompanying side effects. In contrast, these limitations can be easily overcome in a bacteria‐mediated approach. Salmonella is a bacterium, which is known for its ability to colonize solid or semisolid tumours more efficiently than any other bacteria. Among more than 2500 serovars of Salmonella, S. Typhimurium has been widely studied for its antagonistic effects on cancer cells. Here in, we review the current status of the preclinical and the clinical studies with a focus on the mechanisms that attribute the anticancer properties to nontyphoidal Salmonella.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31038778</pmid><doi>10.1111/jam.14297</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3535-5528</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals anticancer agents Anticancer properties Antineoplastic Agents - therapeutic use Bacteria bacteria‐mediated cancer therapy bactofection Cancer Humans Neoplasms - microbiology Neoplasms - therapy Salmonella Salmonella - growth & development Salmonella - physiology Salmonella typhimurium - growth & development Salmonella typhimurium - physiology Salmonella‐tumour interaction Semisolids Side effects Tumors |
| title | Nontyphoidal Salmonella: a potential anticancer agent |
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