Elucidation of the melitidin biosynthesis pathway in pummelo

ABSTRACT Specialized plant metabolism is a rich resource of compounds for drug discovery. The acylated flavonoid glycoside melitidin is being developed as an anti‐cholesterol statin drug candidate, but its biosynthetic route in plants has not yet been fully characterized. Here, we describe the gene...

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Veröffentlicht in:	Journal of integrative plant biology 2023-11, Vol.65 (11), p.2505-2518
Hauptverfasser:	Shen, Shuangqian, Wang, Shouchuang, Yang, Chenkun, Wang, Chao, Zhou, Qianqian, Zhou, Shen, Zhang, Ran, Li, Yufei, Wang, Zixuan, Dai, Liupan, Peng, Wenjv, Hao, Yingchen, Guo, Hao, Cao, Guangping, Liu, Xianqing, Yao, Fan, Xu, Qiang, Fernie, Alisdair R., Luo, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	bioactive metabolites Biological activity Biosynthesis biosynthetic pathway Cholesterol Citrus grandis Drug development Flavone glycosides Flavonoids Gene expression Genetic improvement Genetic resources melitidin Metabolic engineering Metabolism Metabolites natural variation Plant metabolism Reductases Statins Substrates
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