18α甘草酸及其脂质配位体的生物利用度与抗肝损害作用的比较
R96; 目的进一步改善甘草酸的口服吸收及生物利用度以达到治疗目的.方法在惰性溶剂中将甘草酸与磷脂酰胆碱反应形成配位体,然后对甘草酸及其脂质配位体进行生物利用度与抗肝损害实验并作对比.结果甘草酸形成脂质配位体后为脂溶性物,其生物利用度为原甘草酸的4.87倍[甘草酸脂质配位体血药浓度-时间曲线下面积(AUC)28.43μg@h/ml、甘草酸AUC 5.83μg@h/ml],抗肝损害作用与甘草酸对比差异有显著性意义,给药后肝损害大鼠48h谷丙转氨酶(ALT)分别为71.50+11.40IU/L、97.70+24.80IU/L.结论甘草酸脂质配位体的生物利用度与抗肝损害作用均优于甘草酸....
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| Veröffentlicht in: | 浙江医学 2001, Vol.23 (8), p.466-468 |
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| container_title | 浙江医学 |
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| creator | 茹仁萍 吴锡铭 |
| description | R96; 目的进一步改善甘草酸的口服吸收及生物利用度以达到治疗目的.方法在惰性溶剂中将甘草酸与磷脂酰胆碱反应形成配位体,然后对甘草酸及其脂质配位体进行生物利用度与抗肝损害实验并作对比.结果甘草酸形成脂质配位体后为脂溶性物,其生物利用度为原甘草酸的4.87倍[甘草酸脂质配位体血药浓度-时间曲线下面积(AUC)28.43μg@h/ml、甘草酸AUC 5.83μg@h/ml],抗肝损害作用与甘草酸对比差异有显著性意义,给药后肝损害大鼠48h谷丙转氨酶(ALT)分别为71.50+11.40IU/L、97.70+24.80IU/L.结论甘草酸脂质配位体的生物利用度与抗肝损害作用均优于甘草酸. |
| doi_str_mv | 10.3969/j.issn.1006-2785.2001.08.008 |
| format | Article |
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| title | 18α甘草酸及其脂质配位体的生物利用度与抗肝损害作用的比较 |
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