Inhibition of P2X7 Receptor by Extracts of Chinese Medicine
R2-03; 目的:探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02(α-细辛脑)和迷迭香抽提物X0728对人肥大细胞的作用.方法:用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流.结果:40μg/mL SCP01抑制P2X7电流(27.6±2.0)%,而同样浓度的SCP02抑制(29.5±2.2)%(-100 mV电位下),笔者还比较了商业用α-细辛脑的效厘,42 μg/mL可抑制P2X7电流(52.2±2.0)%.相反,40 μg/mL X0728激活P2X7电流(28.6±2.8)%,所有这些作用都是电压依赖性的.结论:α-细辛脑对P2X7的抑制将阻滞胞内钙的增加,从...
Gespeichert in:
| Veröffentlicht in: | 针灸推拿医学（英文版） 2008, Vol.6 (5), p.286-288 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | chi |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 288 |
|---|---|
| container_issue | 5 |
| container_start_page | 286 |
| container_title | 针灸推拿医学（英文版） |
| container_volume | 6 |
| creator | Andreas Spielmann 顾全保 马春辉 黄成钢 宣利江 Wolfgang Schwarz |
| description | R2-03; 目的:探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02(α-细辛脑)和迷迭香抽提物X0728对人肥大细胞的作用.方法:用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流.结果:40μg/mL SCP01抑制P2X7电流(27.6±2.0)%,而同样浓度的SCP02抑制(29.5±2.2)%(-100 mV电位下),笔者还比较了商业用α-细辛脑的效厘,42 μg/mL可抑制P2X7电流(52.2±2.0)%.相反,40 μg/mL X0728激活P2X7电流(28.6±2.8)%,所有这些作用都是电压依赖性的.结论:α-细辛脑对P2X7的抑制将阻滞胞内钙的增加,从而可以解释抑制神经元死亡的原因.而X0728刺激P2X7的药理学效应尚需进一步研究. |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour</sourceid><recordid>TN_cdi_wanfang_journals_zjtnyx_e200805013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>zjtnyx_e200805013</wanfj_id><sourcerecordid>zjtnyx_e200805013</sourcerecordid><originalsourceid>FETCH-wanfang_journals_zjtnyx_e2008050133</originalsourceid><addsrcrecordid>eNpjYeA0NDM30jU2tTTnYOAtLs5MMjAwMzcwNTW35GSw9szLyEzKLMnMz1PIT1MIMIowVwhKTU4tKMkvUkiqVHCtKClKTC4pBkk6Z2TmpRanKvimpmQmA5k8DKxpiTnFqbxQmptB0801xNlDtzwxLy0xLz0-K7-0KA8oE1-VVZJXWRGfamRgYGFgamBobEyKWgCPDDuj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>SpringerNature Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><source>ProQuest Central</source><creator>Andreas Spielmann ; 顾全保 ; 马春辉 ; 黄成钢 ; 宣利江 ; Wolfgang Schwarz</creator><creatorcontrib>Andreas Spielmann ; 顾全保 ; 马春辉 ; 黄成钢 ; 宣利江 ; Wolfgang Schwarz</creatorcontrib><description>R2-03; 目的:探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02(α-细辛脑)和迷迭香抽提物X0728对人肥大细胞的作用.方法:用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流.结果:40μg/mL SCP01抑制P2X7电流(27.6±2.0)%,而同样浓度的SCP02抑制(29.5±2.2)%(-100 mV电位下),笔者还比较了商业用α-细辛脑的效厘,42 μg/mL可抑制P2X7电流(52.2±2.0)%.相反,40 μg/mL X0728激活P2X7电流(28.6±2.8)%,所有这些作用都是电压依赖性的.结论:α-细辛脑对P2X7的抑制将阻滞胞内钙的增加,从而可以解释抑制神经元死亡的原因.而X0728刺激P2X7的药理学效应尚需进一步研究.</description><identifier>ISSN: 1672-3597</identifier><language>chi</language><publisher>Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy%Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203, P. R. China%Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China%Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy</publisher><ispartof>针灸推拿医学（英文版）, 2008, Vol.6 (5), p.286-288</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zjtnyx-e/zjtnyx-e.jpg</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>Andreas Spielmann</creatorcontrib><creatorcontrib>顾全保</creatorcontrib><creatorcontrib>马春辉</creatorcontrib><creatorcontrib>黄成钢</creatorcontrib><creatorcontrib>宣利江</creatorcontrib><creatorcontrib>Wolfgang Schwarz</creatorcontrib><title>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</title><title>针灸推拿医学（英文版）</title><description>R2-03; 目的:探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02(α-细辛脑)和迷迭香抽提物X0728对人肥大细胞的作用.方法:用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流.结果:40μg/mL SCP01抑制P2X7电流(27.6±2.0)%,而同样浓度的SCP02抑制(29.5±2.2)%(-100 mV电位下),笔者还比较了商业用α-细辛脑的效厘,42 μg/mL可抑制P2X7电流(52.2±2.0)%.相反,40 μg/mL X0728激活P2X7电流(28.6±2.8)%,所有这些作用都是电压依赖性的.结论:α-细辛脑对P2X7的抑制将阻滞胞内钙的增加,从而可以解释抑制神经元死亡的原因.而X0728刺激P2X7的药理学效应尚需进一步研究.</description><issn>1672-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0NDM30jU2tTTnYOAtLs5MMjAwMzcwNTW35GSw9szLyEzKLMnMz1PIT1MIMIowVwhKTU4tKMkvUkiqVHCtKClKTC4pBkk6Z2TmpRanKvimpmQmA5k8DKxpiTnFqbxQmptB0801xNlDtzwxLy0xLz0-K7-0KA8oE1-VVZJXWRGfamRgYGFgamBobEyKWgCPDDuj</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Andreas Spielmann</creator><creator>顾全保</creator><creator>马春辉</creator><creator>黄成钢</creator><creator>宣利江</creator><creator>Wolfgang Schwarz</creator><general>Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy%Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203, P. R. China%Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China%Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy</general><general>Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203, P.R. China</general><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2008</creationdate><title>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</title><author>Andreas Spielmann ; 顾全保 ; 马春辉 ; 黄成钢 ; 宣利江 ; Wolfgang Schwarz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wanfang_journals_zjtnyx_e2008050133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andreas Spielmann</creatorcontrib><creatorcontrib>顾全保</creatorcontrib><creatorcontrib>马春辉</creatorcontrib><creatorcontrib>黄成钢</creatorcontrib><creatorcontrib>宣利江</creatorcontrib><creatorcontrib>Wolfgang Schwarz</creatorcontrib><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>针灸推拿医学（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreas Spielmann</au><au>顾全保</au><au>马春辉</au><au>黄成钢</au><au>宣利江</au><au>Wolfgang Schwarz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</atitle><jtitle>针灸推拿医学（英文版）</jtitle><date>2008</date><risdate>2008</risdate><volume>6</volume><issue>5</issue><spage>286</spage><epage>288</epage><pages>286-288</pages><issn>1672-3597</issn><abstract>R2-03; 目的:探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02(α-细辛脑)和迷迭香抽提物X0728对人肥大细胞的作用.方法:用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流.结果:40μg/mL SCP01抑制P2X7电流(27.6±2.0)%,而同样浓度的SCP02抑制(29.5±2.2)%(-100 mV电位下),笔者还比较了商业用α-细辛脑的效厘,42 μg/mL可抑制P2X7电流(52.2±2.0)%.相反,40 μg/mL X0728激活P2X7电流(28.6±2.8)%,所有这些作用都是电压依赖性的.结论:α-细辛脑对P2X7的抑制将阻滞胞内钙的增加,从而可以解释抑制神经元死亡的原因.而X0728刺激P2X7的药理学效应尚需进一步研究.</abstract><pub>Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy%Shanghai Research Center of Acupuncture and Meridian, Shanghai 201203, P. R. China%Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China%Max-Ptanck-Institute for Biophysics, Frankfurt/Main, Gemamy</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-3597 |
| ispartof | 针灸推拿医学（英文版）, 2008, Vol.6 (5), p.286-288 |
| issn | 1672-3597 |
| language | chi |
| recordid | cdi_wanfang_journals_zjtnyx_e200805013 |
| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); SpringerNature Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection; ProQuest Central |
| title | Inhibition of P2X7 Receptor by Extracts of Chinese Medicine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T16%3A05%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20P2X7%20Receptor%20by%20Extracts%20of%20Chinese%20Medicine&rft.jtitle=%E9%92%88%E7%81%B8%E6%8E%A8%E6%8B%BF%E5%8C%BB%E5%AD%A6%EF%BC%88%E8%8B%B1%E6%96%87%E7%89%88%EF%BC%89&rft.au=Andreas%20Spielmann&rft.date=2008&rft.volume=6&rft.issue=5&rft.spage=286&rft.epage=288&rft.pages=286-288&rft.issn=1672-3597&rft_id=info:doi/&rft_dat=%3Cwanfang_jour%3Ezjtnyx_e200805013%3C/wanfang_jour%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_wanfj_id=zjtnyx_e200805013&rfr_iscdi=true |