肉苁蓉苯乙醇总苷传递体包封率测定方法的研究

目的建立肉苁蓉苯乙醇总苷传递体包封率的测定方法。方法分别采用透析法、微柱离心法、凝胶过滤法分离传递体和游离药物，利用紫外分光光度法测定苯乙醇总苷含量，并进行方法学考察，优化包封率测定条件0结果3种方法以凝胶过滤法效果最佳，该法能有效地将传递体与游离药物完全分离，传递体柱回收率为98．21％，肉苁蓉苯乙醇总苷回收率为99．59％；3个批次肉苁蓉苯乙醇总苷传递体包封率分别为37．15％、38．00％、37．22％，平均37．62％，相对标准偏差为1．51％。结论凝胶过滤法简便快捷，重复性好，适于肉苁蓉苯乙醇总苷传递体包封率的测定。...

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Veröffentlicht in:	中国医药 2016, Vol.11 (2), p.275-280
1. Verfasser:	许欢欢杨建华吴姗姗朱丹丹居博伟曹丹丹胡君萍
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Schlagworte:	凝胶过滤法包封率微柱离心法肉苁蓉苯乙醇总苷传递体透析法
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creator	许欢欢杨建华吴姗姗朱丹丹居博伟曹丹丹胡君萍
description	目的建立肉苁蓉苯乙醇总苷传递体包封率的测定方法。方法分别采用透析法、微柱离心法、凝胶过滤法分离传递体和游离药物，利用紫外分光光度法测定苯乙醇总苷含量，并进行方法学考察，优化包封率测定条件0结果3种方法以凝胶过滤法效果最佳，该法能有效地将传递体与游离药物完全分离，传递体柱回收率为98．21％，肉苁蓉苯乙醇总苷回收率为99．59％；3个批次肉苁蓉苯乙醇总苷传递体包封率分别为37．15％、38．00％、37．22％，平均37．62％，相对标准偏差为1．51％。结论凝胶过滤法简便快捷，重复性好，适于肉苁蓉苯乙醇总苷传递体包封率的测定。
doi_str_mv	10.3760/cma.j.issn.1673-4777.2016.02.035
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subjects	凝胶过滤法包封率微柱离心法肉苁蓉苯乙醇总苷传递体透析法
title	肉苁蓉苯乙醇总苷传递体包封率测定方法的研究
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