前列腺干细胞抗原在胰腺癌神经浸润转移中作用的研究

目的探讨前列腺干细胞抗原（PSCA）在人胰腺癌神经浸润中的作用。方法80例胰腺癌手术标本切片HE染色，观察记数小血管、小淋巴管、神经纤维浸润数。用鼠抗人PSCA单抗行免疫组化二步法染色，观察肿瘤细胞的阳性情况。结果肿瘤细胞神经浸润阳性与小血管、小淋巴管的浸润呈正相关（r=0．978，r=0．548，P〈0．01或P〈0．05）；肿瘤细胞PSCA表达阳性（53例）与神经浸润阳性（66例）呈正相关（r=0．746，P〈0．01）；肿瘤的恶性程度与PSCA表达呈正相关；PSCA表达与小血管、小淋巴管浸润无关。结论PSCA可能是胰腺癌的特征性分子之一。它可引导胰腺癌细胞向神经纤维趋化和黏附，即起“导航...

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Veröffentlicht in:	Zhongguo yi yao (Beijing ) 2009, Vol.4 (7), p.481-482
1. Verfasser:	孟令新丁兆军陈希平张红迟玉华王丰松
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Schlagworte:	前列腺干细胞抗原神经浸润胰腺肿瘤
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creator	孟令新丁兆军陈希平张红迟玉华王丰松
description	目的探讨前列腺干细胞抗原（PSCA）在人胰腺癌神经浸润中的作用。方法80例胰腺癌手术标本切片HE染色，观察记数小血管、小淋巴管、神经纤维浸润数。用鼠抗人PSCA单抗行免疫组化二步法染色，观察肿瘤细胞的阳性情况。结果肿瘤细胞神经浸润阳性与小血管、小淋巴管的浸润呈正相关（r=0．978，r=0．548，P〈0．01或P〈0．05）；肿瘤细胞PSCA表达阳性（53例）与神经浸润阳性（66例）呈正相关（r=0．746，P〈0．01）；肿瘤的恶性程度与PSCA表达呈正相关；PSCA表达与小血管、小淋巴管浸润无关。结论PSCA可能是胰腺癌的特征性分子之一。它可引导胰腺癌细胞向神经纤维趋化和黏附，即起“导航”和“停泊”作用。
doi_str_mv	10.3760/cma.j.issn.1673-4777.2009.07.001
format	Article
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subjects	前列腺干细胞抗原神经浸润胰腺肿瘤
title	前列腺干细胞抗原在胰腺癌神经浸润转移中作用的研究
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