Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation
Objective: To investigate the change of serum levels of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine kinase ( CK ) in patients undergoing microendoscopic discectomy (MED) and open discectomy.Methods: Forty-four patients with single level lumbar disk herniation were treated, either by...
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Veröffentlicht in: | Chinese journal of traumatology 2007-10, Vol.10 (5), p.311-314 |
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description | Objective: To investigate the change of serum levels of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine kinase ( CK ) in patients undergoing microendoscopic discectomy (MED) and open discectomy.Methods: Forty-four patients with single level lumbar disk herniation were treated, either by MED ( Group A, n = 22) or open discectomy ( Group B, n = 22). Peripheral venous blood samples were taken before surgery and at 24 and 48 hours postoperatively. The operating time,intraoperative blood loss, postoperative hospital stay were recorded. The pain severity of incision was evaluated by visual analog scale after operation and the clinical outcome was evaluated by Oswestry disability index. Statistical comparison was performed by the analysis of variance and Student's t test.Results: The data showed that patients in Group A had a less intraoperative blood loss ( P < 0.05 ), shorter operating length ( P < 0.05), shorter postoperative hospital stay (P < 0.05) and less postoperative pain of incision than those in Group B. Serum levels of IL-6 ( mean, 31.60 ng/L ± 9.88 ng/L vs 39.16 ng/L ±11. 14 ng/L, P<0.05) and CK ( mean, 167.91 U/L ±51.85 U/L vs 401.55 U/L ± 108.86 U/L, P < 0. 05 ) all get to the peak at 24 hours after operation and Group A with the response statistically less than Group B. Serum level of CRP peaked at 24 hours in Group A ( mean, 12.68 mg/L ± 7.10 mg/L vs 20.82 mg/L± 8. 79 mg/L, P < 0. 05 ) and peaked at 48 hours after surgery in Group B ( mean, 10.77 mg/L ± 5.25 mg/L vs 29.95 mg/L ± 14. 85 mg/L, P <0. 05). The clinical outcomes of both groups were the same at 6 months after surgery.Conclusions: Both MED and open discectomy have made good clinical outcomes, however, the less change of IL-6, CRP and CK after operation proves that MED procedure is less traumatic to patients than open discectomy. |
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Peripheral venous blood samples were taken before surgery and at 24 and 48 hours postoperatively. The operating time,intraoperative blood loss, postoperative hospital stay were recorded. The pain severity of incision was evaluated by visual analog scale after operation and the clinical outcome was evaluated by Oswestry disability index. Statistical comparison was performed by the analysis of variance and Student&apos;s t test.Results: The data showed that patients in Group A had a less intraoperative blood loss ( P < 0.05 ), shorter operating length ( P < 0.05), shorter postoperative hospital stay (P < 0.05) and less postoperative pain of incision than those in Group B. Serum levels of IL-6 ( mean, 31.60 ng/L ± 9.88 ng/L vs 39.16 ng/L ±11. 14 ng/L, P<0.05) and CK ( mean, 167.91 U/L ±51.85 U/L vs 401.55 U/L ± 108.86 U/L, P < 0. 05 ) all get to the peak at 24 hours after operation and Group A with the response statistically less than Group B. Serum level of CRP peaked at 24 hours in Group A ( mean, 12.68 mg/L ± 7.10 mg/L vs 20.82 mg/L± 8. 79 mg/L, P < 0. 05 ) and peaked at 48 hours after surgery in Group B ( mean, 10.77 mg/L ± 5.25 mg/L vs 29.95 mg/L ± 14. 85 mg/L, P <0. 05). The clinical outcomes of both groups were the same at 6 months after surgery.Conclusions: Both MED and open discectomy have made good clinical outcomes, however, the less change of IL-6, CRP and CK after operation proves that MED procedure is less traumatic to patients than open discectomy.</description><identifier>ISSN: 1008-1275</identifier><identifier>PMID: 17919371</identifier><language>eng</language><publisher>China: Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</publisher><subject>Adult ; C-Reactive Protein - analysis ; Creatine Kinase - blood ; Diskectomy - methods ; Endoscopy ; Female ; Humans ; Interleukin-6 - blood ; Intervertebral Disc Displacement - surgery ; Lumbar Vertebrae - surgery ; Male ; Minimally Invasive Surgical Procedures - methods</subject><ispartof>Chinese journal of traumatology, 2007-10, Vol.10 (5), p.311-314</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85114X/85114X.jpg</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17919371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chao, Zhang</creatorcontrib><creatorcontrib>Yue, Zhou</creatorcontrib><creatorcontrib>Tong-wei, Chu</creatorcontrib><creatorcontrib>Jian, Wang</creatorcontrib><creatorcontrib>Yong, Hao</creatorcontrib><creatorcontrib>Yong, Pan</creatorcontrib><title>Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation</title><title>Chinese journal of traumatology</title><addtitle>Chinese Journal of Traumatology(English Edition)</addtitle><description>Objective: To investigate the change of serum levels of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine kinase ( CK ) in patients undergoing microendoscopic discectomy (MED) and open discectomy.Methods: Forty-four patients with single level lumbar disk herniation were treated, either by MED ( Group A, n = 22) or open discectomy ( Group B, n = 22). Peripheral venous blood samples were taken before surgery and at 24 and 48 hours postoperatively. The operating time,intraoperative blood loss, postoperative hospital stay were recorded. The pain severity of incision was evaluated by visual analog scale after operation and the clinical outcome was evaluated by Oswestry disability index. Statistical comparison was performed by the analysis of variance and Student&apos;s t test.Results: The data showed that patients in Group A had a less intraoperative blood loss ( P < 0.05 ), shorter operating length ( P < 0.05), shorter postoperative hospital stay (P < 0.05) and less postoperative pain of incision than those in Group B. Serum levels of IL-6 ( mean, 31.60 ng/L ± 9.88 ng/L vs 39.16 ng/L ±11. 14 ng/L, P<0.05) and CK ( mean, 167.91 U/L ±51.85 U/L vs 401.55 U/L ± 108.86 U/L, P < 0. 05 ) all get to the peak at 24 hours after operation and Group A with the response statistically less than Group B. Serum level of CRP peaked at 24 hours in Group A ( mean, 12.68 mg/L ± 7.10 mg/L vs 20.82 mg/L± 8. 79 mg/L, P < 0. 05 ) and peaked at 48 hours after surgery in Group B ( mean, 10.77 mg/L ± 5.25 mg/L vs 29.95 mg/L ± 14. 85 mg/L, P <0. 05). The clinical outcomes of both groups were the same at 6 months after surgery.Conclusions: Both MED and open discectomy have made good clinical outcomes, however, the less change of IL-6, CRP and CK after operation proves that MED procedure is less traumatic to patients than open discectomy.</description><subject>Adult</subject><subject>C-Reactive Protein - analysis</subject><subject>Creatine Kinase - blood</subject><subject>Diskectomy - methods</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Minimally Invasive Surgical Procedures - methods</subject><issn>1008-1275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90N9LwzAQB_A-KG5O_wUpCIJgIZe2afIo4i-YiKDPJU0vW2ebbEmDbH-9GZs-3cP3c3fcnSRTIIRnQKtykpx7vyKkoKSszpIJVAJEXsE0-XjrlLNoWuuVXXcqbTuvUI122N6lMu3R-3R0MgxyjOHaWYVtcJhq69I-DI10-47vdInOdNFYc5Gcatl7vDzWWfL19Pj58JLN359fH-7nmQLOICsVQ-DIGyXanOtKSp23XEitQKGkWlISg7YqQCPJgWommGo4UipZoQTLZ8ntYe6PNFqaRb2ywZm4sd4tld_taqSEVKQkANHeHGw8YBPQj_WwP7PvpUEbfM14XggCJMKrIwzNgG29dt0g3bb-e1gE1wegltYsNl3c-28IKRmIomD5LwkNcuM</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Chao, Zhang</creator><creator>Yue, Zhou</creator><creator>Tong-wei, Chu</creator><creator>Jian, Wang</creator><creator>Yong, Hao</creator><creator>Yong, Pan</creator><general>Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20071001</creationdate><title>Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation</title><author>Chao, Zhang ; Yue, Zhou ; Tong-wei, Chu ; Jian, Wang ; Yong, Hao ; Yong, Pan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1861-5c6e18e8bc9d38f7aaf3d89afc1cea2fa209d3d741fe0312f696cb8e22a64c963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>C-Reactive Protein - analysis</topic><topic>Creatine Kinase - blood</topic><topic>Diskectomy - methods</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Intervertebral Disc Displacement - surgery</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Minimally Invasive Surgical Procedures - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chao, Zhang</creatorcontrib><creatorcontrib>Yue, Zhou</creatorcontrib><creatorcontrib>Tong-wei, Chu</creatorcontrib><creatorcontrib>Jian, Wang</creatorcontrib><creatorcontrib>Yong, Hao</creatorcontrib><creatorcontrib>Yong, Pan</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese journal of traumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chao, Zhang</au><au>Yue, Zhou</au><au>Tong-wei, Chu</au><au>Jian, Wang</au><au>Yong, Hao</au><au>Yong, Pan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation</atitle><jtitle>Chinese journal of traumatology</jtitle><addtitle>Chinese Journal of Traumatology(English Edition)</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>10</volume><issue>5</issue><spage>311</spage><epage>314</epage><pages>311-314</pages><issn>1008-1275</issn><abstract>Objective: To investigate the change of serum levels of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine kinase ( CK ) in patients undergoing microendoscopic discectomy (MED) and open discectomy.Methods: Forty-four patients with single level lumbar disk herniation were treated, either by MED ( Group A, n = 22) or open discectomy ( Group B, n = 22). Peripheral venous blood samples were taken before surgery and at 24 and 48 hours postoperatively. The operating time,intraoperative blood loss, postoperative hospital stay were recorded. The pain severity of incision was evaluated by visual analog scale after operation and the clinical outcome was evaluated by Oswestry disability index. Statistical comparison was performed by the analysis of variance and Student&apos;s t test.Results: The data showed that patients in Group A had a less intraoperative blood loss ( P < 0.05 ), shorter operating length ( P < 0.05), shorter postoperative hospital stay (P < 0.05) and less postoperative pain of incision than those in Group B. Serum levels of IL-6 ( mean, 31.60 ng/L ± 9.88 ng/L vs 39.16 ng/L ±11. 14 ng/L, P<0.05) and CK ( mean, 167.91 U/L ±51.85 U/L vs 401.55 U/L ± 108.86 U/L, P < 0. 05 ) all get to the peak at 24 hours after operation and Group A with the response statistically less than Group B. Serum level of CRP peaked at 24 hours in Group A ( mean, 12.68 mg/L ± 7.10 mg/L vs 20.82 mg/L± 8. 79 mg/L, P < 0. 05 ) and peaked at 48 hours after surgery in Group B ( mean, 10.77 mg/L ± 5.25 mg/L vs 29.95 mg/L ± 14. 85 mg/L, P <0. 05). The clinical outcomes of both groups were the same at 6 months after surgery.Conclusions: Both MED and open discectomy have made good clinical outcomes, however, the less change of IL-6, CRP and CK after operation proves that MED procedure is less traumatic to patients than open discectomy.</abstract><cop>China</cop><pub>Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China</pub><pmid>17919371</pmid><tpages>4</tpages></addata></record> |
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subjects | Adult C-Reactive Protein - analysis Creatine Kinase - blood Diskectomy - methods Endoscopy Female Humans Interleukin-6 - blood Intervertebral Disc Displacement - surgery Lumbar Vertebrae - surgery Male Minimally Invasive Surgical Procedures - methods |
title | Microendoscopic discectomy, a less traumatic procedure for lumbar disk herniation |
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