Olmesartan inhibits the expression of monocyte chemoattractant protein-1 and tumor necrosis factor-α and improves vascular remodeling after vascular injury in mouse

Objective: To investigate the neointima formation and the expression of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α(TNF-α) in cuff-induced vascular injury in mouse model, and to examine the effect of angiotensin Ⅱ type 1 receptor ( AT1 ) blocker,olmesartan, on MCP-1 and TN...

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Veröffentlicht in:	Chinese journal of traumatology 2004-02, Vol.7 (1), p.56-61
1. Verfasser:	李震陈小东倪少凯李建文林木生
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Blotting, Western Cell Division - drug effects Cell Division - physiology Cells, Cultured Chemokine CCL2 - analysis Disease Models, Animal Imidazoles - pharmacology Immunohistochemistry Male Mice Mice, Inbred C57BL Monocytes - cytology Monocytes - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Olmesartan Olmesartan Medoxomil Probability Sensitivity and Specificity Tetrazoles - pharmacology Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - drug effects Tunica Intima - drug effects Tunica Intima - pathology Vascular Diseases - physiopathology 动物模型单核细胞化学引诱物蛋白-1 肿瘤坏死因子-α 血管损伤血管重塑
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