Molecular mechanisms of FK506-induced hypertension in solid organ transplantation patients

Objective Tacrolimus （FK506） is an immunosuppressive drug, which is widely used to prevent rejection of transplanted organs. However, chronic administration of FK506 leads to hypertension in solid organ transplantation patients, and its molecular mechanisms are much more complicated. In this review,...

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Veröffentlicht in:	Chinese medical journal 2014, Vol.127 (20), p.3645-3650
Hauptverfasser:	Wang, Jianglin, Guo, Ren, Liu, Shikun, Chen, Qingjie, Zuo, Shanru, Yang, Meng, Zuo, Xiaocong
Format:	Artikel
Sprache:	eng
Schlagworte:	FK506 FKBP12 Humans Hypertension - chemically induced Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Organ Transplantation - adverse effects Tacrolimus - adverse effects Tacrolimus - therapeutic use 分子机制 器官移植 妊高征 实体 患者 蛋白激酶C
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