Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions

Background Mitochondrial dysfunction has been reported to be one of the contributing factors of sepsis-associated encephalopathy （SAE）.Mitochondrial biogenesis controls mitochondrial homeostasis and responds to changes in cellular energy demand.In addition,it is enhanced or decreased due to mitochon...

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Veröffentlicht in:	Chinese medical journal 2014, Vol.127 (10), p.1837-1842
Hauptverfasser:	Wang, Yang, Chen, Zhijiang, Zhang, Yu, Fang, Suzhen, Zeng, Qiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism ATP水平 Blotting, Western Cells, Cultured DNA, Mitochondrial - genetics Electrophoretic Mobility Shift Assay Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Microscopy, Electron, Transmission Mitochondrial Turnover - drug effects Mitochondrial Turnover - physiology mtDNA Nitric Oxide - metabolism Rats Reactive Nitrogen Species - metabolism Sepsis - metabolism Tumor Necrosis Factor-alpha - metabolism 实验条件感染性星形胶质细胞生物合成线粒体DNA 透射电子显微镜
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