Recombinant human thrombopoietin in combination with cyclosporin A as a novel therapy in corticosteroid-resistant primary immune thrombocytopenia
Background The management of patients with refractory immune thrombocytopenia （ITP） is challenging, as there is no standard treatment option. The aim of this study was to investigate the efficacy of recombinant human thrombopoietin （rhTPO） in combination with cyclosporin A （CsA） for the management o...
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| Veröffentlicht in: | Chinese medical journal 2013-11, Vol.126 (21), p.4145-4148 |
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| container_issue | 21 |
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| container_title | Chinese medical journal |
| container_volume | 126 |
| creator | Cui, Zhong-Guang Liu, Xin-Guang Qin, Ping Hou, Ming Wu, Shao-Ling Peng, Jun Zhao, Hong-Guo Wang, Hong-Yi Zhao, Chun-Ting |
| description | Background The management of patients with refractory immune thrombocytopenia （ITP） is challenging, as there is no standard treatment option. The aim of this study was to investigate the efficacy of recombinant human thrombopoietin （rhTPO） in combination with cyclosporin A （CsA） for the management of patients with corticosteroid-resistant primary ITP. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.20131116 |
| format | Article |
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The aim of this study was to investigate the efficacy of recombinant human thrombopoietin （rhTPO） in combination with cyclosporin A （CsA） for the management of patients with corticosteroid-resistant primary ITP.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.20131116</identifier><identifier>PMID: 24229688</identifier><language>eng</language><publisher>China: Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China</publisher><subject>Adolescent ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Aged ; Cyclosporine - administration & dosage ; Cyclosporine - therapeutic use ; Drug Resistance ; Female ; Humans ; Male ; Middle Aged ; Recombinant Proteins - therapeutic use ; Thrombocytopenia - drug therapy ; Thrombopoietin - adverse effects ; Thrombopoietin - therapeutic use ; Treatment Outcome ; Young Adult ; 人血小板生成素 ; 免疫性 ; 治疗方案 ; 环孢素A ; 皮质 ; 素性 ; 血小板减少 ; 重组</subject><ispartof>Chinese medical journal, 2013-11, Vol.126 (21), p.4145-4148</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-c84fbe9524daf7e2e264b395813a160da0717edaba33391ec864ee7d587b7a003</citedby><cites>FETCH-LOGICAL-c437t-c84fbe9524daf7e2e264b395813a160da0717edaba33391ec864ee7d587b7a003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24229688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Zhong-Guang</creatorcontrib><creatorcontrib>Liu, Xin-Guang</creatorcontrib><creatorcontrib>Qin, Ping</creatorcontrib><creatorcontrib>Hou, Ming</creatorcontrib><creatorcontrib>Wu, Shao-Ling</creatorcontrib><creatorcontrib>Peng, Jun</creatorcontrib><creatorcontrib>Zhao, Hong-Guo</creatorcontrib><creatorcontrib>Wang, Hong-Yi</creatorcontrib><creatorcontrib>Zhao, Chun-Ting</creatorcontrib><title>Recombinant human thrombopoietin in combination with cyclosporin A as a novel therapy in corticosteroid-resistant primary immune thrombocytopenia</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background The management of patients with refractory immune thrombocytopenia （ITP） is challenging, as there is no standard treatment option. The aim of this study was to investigate the efficacy of recombinant human thrombopoietin （rhTPO） in combination with cyclosporin A （CsA） for the management of patients with corticosteroid-resistant primary ITP.</description><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - therapeutic use</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Thrombocytopenia - drug therapy</subject><subject>Thrombopoietin - adverse effects</subject><subject>Thrombopoietin - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><subject>人血小板生成素</subject><subject>免疫性</subject><subject>治疗方案</subject><subject>环孢素A</subject><subject>皮质</subject><subject>素性</subject><subject>血小板减少</subject><subject>重组</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc-K1TAUh4sozp3RV5C6UNy05l-TduFiGHQUBgTRdUjT02lKm3SSdIbrW_jGptzegUAg-c75JefLsg8YlVRw9FnPqhxLE4ItEeW84E3TlARhijHmL7IDqRgpKs7wy-zwDFxklyGMCJGqEvx1dkEYIQ2v60P27xdoN7fGKhvzYZ2VzePg04lbnIFobJ7WTkTjbP5k4pDro55cWJxPl9e5CrnKrXuEKdWCV8vxVOSj0S5E8M50hYdgQtxSFm9m5RMzz6uFc5w-RreANepN9qpXU4C3-36V_fn29ffN9-Lu5-2Pm-u7QjMqYqFr1rfQVIR1qhdAgHDW0qaqMVWYo04hgQV0qlWU0gaDrjkDEF1Vi1YohOhV9vHU90nZXtl7ObrV25Qo_w56HreREpwmlsBPJ3Dx7mGFEOVsgoZpUhbcGiRmVYNT2wYn9MsJ1d6F4KGX-2clRnLTJ5M-OcpNn9zsyM2OPOtL9e_2qLWdoXuuPvtKwPs9YHD2_sGkZ58ZJkRNmMD0P68bqT0</recordid><startdate>20131105</startdate><enddate>20131105</enddate><creator>Cui, Zhong-Guang</creator><creator>Liu, Xin-Guang</creator><creator>Qin, Ping</creator><creator>Hou, Ming</creator><creator>Wu, Shao-Ling</creator><creator>Peng, Jun</creator><creator>Zhao, Hong-Guo</creator><creator>Wang, Hong-Yi</creator><creator>Zhao, Chun-Ting</creator><general>Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China</general><general>Department of Hematology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, China%Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China%Department of Hematology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20131105</creationdate><title>Recombinant human thrombopoietin in combination with cyclosporin A as a novel therapy in corticosteroid-resistant primary immune thrombocytopenia</title><author>Cui, Zhong-Guang ; Liu, Xin-Guang ; Qin, Ping ; Hou, Ming ; Wu, Shao-Ling ; Peng, Jun ; Zhao, Hong-Guo ; Wang, Hong-Yi ; Zhao, Chun-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-c84fbe9524daf7e2e264b395813a160da0717edaba33391ec864ee7d587b7a003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - therapeutic use</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Thrombocytopenia - drug therapy</topic><topic>Thrombopoietin - adverse effects</topic><topic>Thrombopoietin - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><topic>人血小板生成素</topic><topic>免疫性</topic><topic>治疗方案</topic><topic>环孢素A</topic><topic>皮质</topic><topic>素性</topic><topic>血小板减少</topic><topic>重组</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Zhong-Guang</creatorcontrib><creatorcontrib>Liu, Xin-Guang</creatorcontrib><creatorcontrib>Qin, Ping</creatorcontrib><creatorcontrib>Hou, Ming</creatorcontrib><creatorcontrib>Wu, Shao-Ling</creatorcontrib><creatorcontrib>Peng, Jun</creatorcontrib><creatorcontrib>Zhao, Hong-Guo</creatorcontrib><creatorcontrib>Wang, Hong-Yi</creatorcontrib><creatorcontrib>Zhao, Chun-Ting</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Zhong-Guang</au><au>Liu, Xin-Guang</au><au>Qin, Ping</au><au>Hou, Ming</au><au>Wu, Shao-Ling</au><au>Peng, Jun</au><au>Zhao, Hong-Guo</au><au>Wang, Hong-Yi</au><au>Zhao, Chun-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant human thrombopoietin in combination with cyclosporin A as a novel therapy in corticosteroid-resistant primary immune thrombocytopenia</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2013-11-05</date><risdate>2013</risdate><volume>126</volume><issue>21</issue><spage>4145</spage><epage>4148</epage><pages>4145-4148</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background The management of patients with refractory immune thrombocytopenia （ITP） is challenging, as there is no standard treatment option. The aim of this study was to investigate the efficacy of recombinant human thrombopoietin （rhTPO） in combination with cyclosporin A （CsA） for the management of patients with corticosteroid-resistant primary ITP.</abstract><cop>China</cop><pub>Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China</pub><pmid>24229688</pmid><doi>10.3760/cma.j.issn.0366-6999.20131116</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2013-11, Vol.126 (21), p.4145-4148 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adrenal Cortex Hormones - therapeutic use Adult Aged Cyclosporine - administration & dosage Cyclosporine - therapeutic use Drug Resistance Female Humans Male Middle Aged Recombinant Proteins - therapeutic use Thrombocytopenia - drug therapy Thrombopoietin - adverse effects Thrombopoietin - therapeutic use Treatment Outcome Young Adult 人血小板生成素 免疫性 治疗方案 环孢素A 皮质 素性 血小板减少 重组 |
| title | Recombinant human thrombopoietin in combination with cyclosporin A as a novel therapy in corticosteroid-resistant primary immune thrombocytopenia |
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