Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2
Background The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metallop...
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| Veröffentlicht in: | Chinese medical journal 2013-05, Vol.126 (10), p.1925-1929 |
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| description | Background The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metall0Proteinase-2. Methods The correlations were studied bY detecting the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloProteinase-1, and tissue inhibitor of metalloproteinase-2 by enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the peripheral blood of 30 patients with papillary thyroid carcinoma, 27 patients with benign thyroid disease, and 25 hea !hy vo!unteers. Results The leve!s of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those in the peripheral blood of patients with benign thyroid disease and healthy volunteers （P 〈0.05）. However, there were no significant differences between patients with benign thyroid disease and healthy volunteers （P 〉0.05）. The accuracy of detection by both enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the papillary thyroid cancer group was 83.33%. Conclusions The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood are helpful in identifying thyroid carcinoma and aid in preoperative assessment. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.20130172 |
| format | Article |
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The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metall0Proteinase-2. Methods The correlations were studied bY detecting the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloProteinase-1, and tissue inhibitor of metalloproteinase-2 by enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the peripheral blood of 30 patients with papillary thyroid carcinoma, 27 patients with benign thyroid disease, and 25 hea !hy vo!unteers. Results The leve!s of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those in the peripheral blood of patients with benign thyroid disease and healthy volunteers （P 〈0.05）. However, there were no significant differences between patients with benign thyroid disease and healthy volunteers （P 〉0.05）. The accuracy of detection by both enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the papillary thyroid cancer group was 83.33%. Conclusions The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood are helpful in identifying thyroid carcinoma and aid in preoperative assessment.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.20130172</identifier><identifier>PMID: 23673111</identifier><language>eng</language><publisher>China: Department of General Surgery, Qilu Hospital, Shandong University,Jinan, Shandong 250012, China%Department of General Surgery, Qingdao Municipal Hospital,Qingdao, Shandong 266071, China</publisher><subject>Adult ; Aged ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Middle Aged ; Reverse Transcriptase Polymerase Chain Reaction ; Thyroid Neoplasms - blood ; Thyroid Neoplasms - pathology ; Tissue Inhibitor of Metalloproteinase-1 - blood ; Tissue Inhibitor of Metalloproteinase-2 - blood ; 乳头 ; 基质金属蛋白酶-2 ; 基质金属蛋白酶-9 ; 外周血 ; 甲状腺癌 ; 组织抑制剂 ; 逆转录聚合酶链反应 ; 酶联免疫吸附试验</subject><ispartof>Chinese medical journal, 2013-05, Vol.126 (10), p.1925-1929</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-96a6f20414a075d304e0692c0e208492ea81e22f1d8e6c9b0efb17f3509cea3e3</citedby><cites>FETCH-LOGICAL-c437t-96a6f20414a075d304e0692c0e208492ea81e22f1d8e6c9b0efb17f3509cea3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23673111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Shao-Fei</creatorcontrib><creatorcontrib>Hu, San-Yuan</creatorcontrib><creatorcontrib>Ma, Lei</creatorcontrib><creatorcontrib>Miao, Lei</creatorcontrib><creatorcontrib>Mao, Wei-Zheng</creatorcontrib><title>Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metall0Proteinase-2. Methods The correlations were studied bY detecting the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloProteinase-1, and tissue inhibitor of metalloproteinase-2 by enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the peripheral blood of 30 patients with papillary thyroid carcinoma, 27 patients with benign thyroid disease, and 25 hea !hy vo!unteers. Results The leve!s of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those in the peripheral blood of patients with benign thyroid disease and healthy volunteers （P 〈0.05）. However, there were no significant differences between patients with benign thyroid disease and healthy volunteers （P 〉0.05）. The accuracy of detection by both enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the papillary thyroid cancer group was 83.33%. Conclusions The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood are helpful in identifying thyroid carcinoma and aid in preoperative assessment.</description><subject>Adult</subject><subject>Aged</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Middle Aged</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - blood</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - blood</subject><subject>乳头</subject><subject>基质金属蛋白酶-2</subject><subject>基质金属蛋白酶-9</subject><subject>外周血</subject><subject>甲状腺癌</subject><subject>组织抑制剂</subject><subject>逆转录聚合酶链反应</subject><subject>酶联免疫吸附试验</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhS0EokPhFZBZgFhMgn8Se7JggUb8SZXYwNpykpvGUWKnttPSvmnfBqcz0w1CYuWFv3vPvfcchN5SknMpyIdm0vmQmxBsTrgQmaiqKmeEckIle4I2rCxYVoqCPkWbR-AMvQhhIISVpRTP0RnjQnJK6Qbd7533MOponA24hngDYPGsZzOO2t_i2N96Z1rcaNuAx9q2eAZv5h68HnE9OtfiEa5hDNh1eNLRm994gqjH0c3eRTBWB8jY9t9_1RbHtM8C2Nje1CY6_9DrL5BuH_T_D2Yv0bNOjwFeHd9z9OvL55_7b9nFj6_f958usqbgMmaV0KJjpKCFJrJsOSmAiIo1BBjZFRUDvaPAWEfbHYimqgl0NZUdL0nVgObAz9G7Q98bbTttL9XgFm-Torrrm2lYraHp8jyB7w9gmvJqgRDVZEID6c4W3BIU5SVjcic5S-jHA9p4F4KHTs3eTMkPRYlaY6BSDNSg1hio1WW1uqxOMUj1r49SSz1B-1h98j0Bb44CvbOXVyaNfWKKsiIyYfwPpkfC-w</recordid><startdate>20130520</startdate><enddate>20130520</enddate><creator>Zhou, Shao-Fei</creator><creator>Hu, San-Yuan</creator><creator>Ma, Lei</creator><creator>Miao, Lei</creator><creator>Mao, Wei-Zheng</creator><general>Department of General Surgery, Qilu Hospital, Shandong University,Jinan, Shandong 250012, China%Department of General Surgery, Qingdao Municipal Hospital,Qingdao, Shandong 266071, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20130520</creationdate><title>Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2</title><author>Zhou, Shao-Fei ; Hu, San-Yuan ; Ma, Lei ; Miao, Lei ; Mao, Wei-Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-96a6f20414a075d304e0692c0e208492ea81e22f1d8e6c9b0efb17f3509cea3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Middle Aged</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - blood</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - blood</topic><topic>乳头</topic><topic>基质金属蛋白酶-2</topic><topic>基质金属蛋白酶-9</topic><topic>外周血</topic><topic>甲状腺癌</topic><topic>组织抑制剂</topic><topic>逆转录聚合酶链反应</topic><topic>酶联免疫吸附试验</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Shao-Fei</creatorcontrib><creatorcontrib>Hu, San-Yuan</creatorcontrib><creatorcontrib>Ma, Lei</creatorcontrib><creatorcontrib>Miao, Lei</creatorcontrib><creatorcontrib>Mao, Wei-Zheng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Shao-Fei</au><au>Hu, San-Yuan</au><au>Ma, Lei</au><au>Miao, Lei</au><au>Mao, Wei-Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2013-05-20</date><risdate>2013</risdate><volume>126</volume><issue>10</issue><spage>1925</spage><epage>1929</epage><pages>1925-1929</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metall0Proteinase-2. Methods The correlations were studied bY detecting the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloProteinase-1, and tissue inhibitor of metalloproteinase-2 by enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the peripheral blood of 30 patients with papillary thyroid carcinoma, 27 patients with benign thyroid disease, and 25 hea !hy vo!unteers. Results The leve!s of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those in the peripheral blood of patients with benign thyroid disease and healthy volunteers （P 〈0.05）. However, there were no significant differences between patients with benign thyroid disease and healthy volunteers （P 〉0.05）. The accuracy of detection by both enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the papillary thyroid cancer group was 83.33%. Conclusions The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood are helpful in identifying thyroid carcinoma and aid in preoperative assessment.</abstract><cop>China</cop><pub>Department of General Surgery, Qilu Hospital, Shandong University,Jinan, Shandong 250012, China%Department of General Surgery, Qingdao Municipal Hospital,Qingdao, Shandong 266071, China</pub><pmid>23673111</pmid><doi>10.3760/cma.j.issn.0366-6999.20130172</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Enzyme-Linked Immunosorbent Assay Female Humans Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Middle Aged Reverse Transcriptase Polymerase Chain Reaction Thyroid Neoplasms - blood Thyroid Neoplasms - pathology Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-2 - blood 乳头 基质金属蛋白酶-2 基质金属蛋白酶-9 外周血 甲状腺癌 组织抑制剂 逆转录聚合酶链反应 酶联免疫吸附试验 |
| title | Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 |
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