Thrombosis and morphology of plaque rupture using optical coherence tomography
Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT）...
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| Veröffentlicht in: | Chinese medical journal 2013-03, Vol.126 (6), p.1092-1095 |
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| creator | Guo, Jun Chen, Yun-Dai Tian, Feng Liu, Hong-Bin Chen, Lian Sun, Zhi-Jun Ren, Yi-Hong Jin, Qin-Hua Liu, Chang-Fu Han, Bao-Shi Gai, Lu-Yue Yang, Ting-Shu |
| description | Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.20122642 |
| format | Article |
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There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.20122642</identifier><identifier>PMID: 23506584</identifier><language>eng</language><publisher>China: Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China</publisher><subject>Acute Coronary Syndrome - diagnostic imaging ; Acute Coronary Syndrome - etiology ; Adult ; Aged ; Coronary Angiography ; Female ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic - complications ; Plaque, Atherosclerotic - diagnostic imaging ; Rupture, Spontaneous - complications ; Tomography, Optical Coherence - methods ; 光学相干 ; 冠状动脉粥样硬化 ; 形态特征 ; 急性冠脉综合征 ; 斑块破裂 ; 断层扫描 ; 粗纤维 ; 血栓形成</subject><ispartof>Chinese medical journal, 2013-03, Vol.126 (6), p.1092-1095</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-e28b7f0b1137e917f75d3688da1ae9a23721e9d69ed9afbf1260d90d0d365bbe3</citedby><cites>FETCH-LOGICAL-c437t-e28b7f0b1137e917f75d3688da1ae9a23721e9d69ed9afbf1260d90d0d365bbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23506584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Jun</creatorcontrib><creatorcontrib>Chen, Yun-Dai</creatorcontrib><creatorcontrib>Tian, Feng</creatorcontrib><creatorcontrib>Liu, Hong-Bin</creatorcontrib><creatorcontrib>Chen, Lian</creatorcontrib><creatorcontrib>Sun, Zhi-Jun</creatorcontrib><creatorcontrib>Ren, Yi-Hong</creatorcontrib><creatorcontrib>Jin, Qin-Hua</creatorcontrib><creatorcontrib>Liu, Chang-Fu</creatorcontrib><creatorcontrib>Han, Bao-Shi</creatorcontrib><creatorcontrib>Gai, Lu-Yue</creatorcontrib><creatorcontrib>Yang, Ting-Shu</creatorcontrib><title>Thrombosis and morphology of plaque rupture using optical coherence tomography</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.</description><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Acute Coronary Syndrome - etiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Coronary Angiography</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plaque, Atherosclerotic - complications</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Rupture, Spontaneous - complications</subject><subject>Tomography, Optical Coherence - methods</subject><subject>光学相干</subject><subject>冠状动脉粥样硬化</subject><subject>形态特征</subject><subject>急性冠脉综合征</subject><subject>斑块破裂</subject><subject>断层扫描</subject><subject>粗纤维</subject><subject>血栓形成</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MtO3DAUgGELgcoU-grILKi6Seq74wULhFpAGrUbWFtO4tyU2MFOVA1PX49mmJU3_zlH_gC4wyinUqCf1WTyIe9jdDmiQmRCKZUThAkRjJyBDeGMZFwwfA42p-ASfI1xQIhwLsUXcEkoR4IXbAP-vHbBT6WPfYTG1XDyYe786Nsd9A2cR_O-WhjWeVmDhWvsXQv9vPSVGWHlOxusqyxc_OTbYOZudw0uGjNG--34XoG3379eH5-z7d-nl8eHbVYxKpfMkqKUDSoxptIqLBvJayqKojbYWGUIlQRbVQtla2WassFEoFqhGqWKl6WlV-D7Ye8_4xrjWj34Nbh0UX901TQkD4oEwjKFPw7hHHz6Slz01MfKjqNx1q9RY4oLpJhSIqX3h7QKPsZgGz2HfjJhpzHSe3ud7PWg9_Z6T6v3tPrTPs3fHE-t5WTr0_Qndgpujwc679r3ZHlqGMecccnofyP4j2E</recordid><startdate>20130320</startdate><enddate>20130320</enddate><creator>Guo, Jun</creator><creator>Chen, Yun-Dai</creator><creator>Tian, Feng</creator><creator>Liu, Hong-Bin</creator><creator>Chen, Lian</creator><creator>Sun, Zhi-Jun</creator><creator>Ren, Yi-Hong</creator><creator>Jin, Qin-Hua</creator><creator>Liu, Chang-Fu</creator><creator>Han, Bao-Shi</creator><creator>Gai, Lu-Yue</creator><creator>Yang, Ting-Shu</creator><general>Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20130320</creationdate><title>Thrombosis and morphology of plaque rupture using optical coherence tomography</title><author>Guo, Jun ; Chen, Yun-Dai ; Tian, Feng ; Liu, Hong-Bin ; Chen, Lian ; Sun, Zhi-Jun ; Ren, Yi-Hong ; Jin, Qin-Hua ; Liu, Chang-Fu ; Han, Bao-Shi ; Gai, Lu-Yue ; Yang, Ting-Shu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-e28b7f0b1137e917f75d3688da1ae9a23721e9d69ed9afbf1260d90d0d365bbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Acute Coronary Syndrome - etiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Coronary Angiography</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plaque, Atherosclerotic - complications</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Rupture, Spontaneous - complications</topic><topic>Tomography, Optical Coherence - methods</topic><topic>光学相干</topic><topic>冠状动脉粥样硬化</topic><topic>形态特征</topic><topic>急性冠脉综合征</topic><topic>斑块破裂</topic><topic>断层扫描</topic><topic>粗纤维</topic><topic>血栓形成</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Jun</creatorcontrib><creatorcontrib>Chen, Yun-Dai</creatorcontrib><creatorcontrib>Tian, Feng</creatorcontrib><creatorcontrib>Liu, Hong-Bin</creatorcontrib><creatorcontrib>Chen, Lian</creatorcontrib><creatorcontrib>Sun, Zhi-Jun</creatorcontrib><creatorcontrib>Ren, Yi-Hong</creatorcontrib><creatorcontrib>Jin, Qin-Hua</creatorcontrib><creatorcontrib>Liu, Chang-Fu</creatorcontrib><creatorcontrib>Han, Bao-Shi</creatorcontrib><creatorcontrib>Gai, Lu-Yue</creatorcontrib><creatorcontrib>Yang, Ting-Shu</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Jun</au><au>Chen, Yun-Dai</au><au>Tian, Feng</au><au>Liu, Hong-Bin</au><au>Chen, Lian</au><au>Sun, Zhi-Jun</au><au>Ren, Yi-Hong</au><au>Jin, Qin-Hua</au><au>Liu, Chang-Fu</au><au>Han, Bao-Shi</au><au>Gai, Lu-Yue</au><au>Yang, Ting-Shu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombosis and morphology of plaque rupture using optical coherence tomography</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2013-03-20</date><risdate>2013</risdate><volume>126</volume><issue>6</issue><spage>1092</spage><epage>1095</epage><pages>1092-1095</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.</abstract><cop>China</cop><pub>Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China</pub><pmid>23506584</pmid><doi>10.3760/cma.j.issn.0366-6999.20122642</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Coronary Syndrome - diagnostic imaging Acute Coronary Syndrome - etiology Adult Aged Coronary Angiography Female Humans Male Middle Aged Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - diagnostic imaging Rupture, Spontaneous - complications Tomography, Optical Coherence - methods 光学相干 冠状动脉粥样硬化 形态特征 急性冠脉综合征 斑块破裂 断层扫描 粗纤维 血栓形成 |
| title | Thrombosis and morphology of plaque rupture using optical coherence tomography |
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