Overexpression of enhancer of zests homolog 2 in lymphoma
Objective This article aimed to review the biological characteristics of enhancer of zests homolog 2 （EZH2）, and the transcriptional repression mechanism of action of EZH2 in tumors, particularly in the progression of lymphoma. Data sources The data cited in this review were mainly obtained from the...
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| Veröffentlicht in: | Chinese medical journal 2012-10, Vol.125 (20), p.3735-3739 |
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| creator | Guo, Shan-Qi Zhang, Yi-Zhuo |
| description | Objective This article aimed to review the biological characteristics of enhancer of zests homolog 2 （EZH2）, and the transcriptional repression mechanism of action of EZH2 in tumors, particularly in the progression of lymphoma. Data sources The data cited in this review were mainly obtained from the articles listed in PubMed and HighWare that were published from March 2004 to April 2012. The search terms were ＂enhancer of zests homolog 2＂, ＂polycomb group＂, and ＂lymphoma＂. Study selection Articles regarding the mechanism of EZH2 in post-transcriptional modification, functions of polycomb group proteins, and the roles of EZH2 in lymphoma were selected. Results EZH2 acts as oncogene and involved in many kinds of tumors. Moreover, it plays an important role in tumorigenesis and lymphomagenesis by promoting the proliferation and aggressiveness of neoplastic cells, facilitating malignant tumor cell diffusion, and mediating transcriptional silencing. Conclusion EZH2 mediated transcriptional repression through its methyltransferase activity at the chromatin level has certain influence on lymphoma, and there might exist a therapeutic window for the development of new agents and identification of novel diagnostic markers based on EZH2. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.2012.20.025 |
| format | Article |
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Data sources The data cited in this review were mainly obtained from the articles listed in PubMed and HighWare that were published from March 2004 to April 2012. The search terms were ＂enhancer of zests homolog 2＂, ＂polycomb group＂, and ＂lymphoma＂. Study selection Articles regarding the mechanism of EZH2 in post-transcriptional modification, functions of polycomb group proteins, and the roles of EZH2 in lymphoma were selected. Results EZH2 acts as oncogene and involved in many kinds of tumors. Moreover, it plays an important role in tumorigenesis and lymphomagenesis by promoting the proliferation and aggressiveness of neoplastic cells, facilitating malignant tumor cell diffusion, and mediating transcriptional silencing. Conclusion EZH2 mediated transcriptional repression through its methyltransferase activity at the chromatin level has certain influence on lymphoma, and there might exist a therapeutic window for the development of new agents and identification of novel diagnostic markers based on EZH2.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2012.20.025</identifier><identifier>PMID: 23075734</identifier><language>eng</language><publisher>China: Department of Hematology and Blood and Marrow Transplantation, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China</publisher><subject>Disease Progression ; Enhancer of Zeste Homolog 2 Protein ; Epigenesis, Genetic ; Histones - metabolism ; Humans ; Lymphoma - etiology ; Lymphoma - genetics ; Methylation ; Mutation ; Polycomb Repressive Complex 2 - genetics ; Polycomb Repressive Complex 2 - physiology ; PubMed ; 同源基因 ; 抑制机制 ; 淋巴瘤 ; 肿瘤发生 ; 肿瘤细胞 ; 转录抑制 ; 过度</subject><ispartof>Chinese medical journal, 2012-10, Vol.125 (20), p.3735-3739</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23075734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Shan-Qi</creatorcontrib><creatorcontrib>Zhang, Yi-Zhuo</creatorcontrib><title>Overexpression of enhancer of zests homolog 2 in lymphoma</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Objective This article aimed to review the biological characteristics of enhancer of zests homolog 2 （EZH2）, and the transcriptional repression mechanism of action of EZH2 in tumors, particularly in the progression of lymphoma. Data sources The data cited in this review were mainly obtained from the articles listed in PubMed and HighWare that were published from March 2004 to April 2012. The search terms were ＂enhancer of zests homolog 2＂, ＂polycomb group＂, and ＂lymphoma＂. Study selection Articles regarding the mechanism of EZH2 in post-transcriptional modification, functions of polycomb group proteins, and the roles of EZH2 in lymphoma were selected. Results EZH2 acts as oncogene and involved in many kinds of tumors. Moreover, it plays an important role in tumorigenesis and lymphomagenesis by promoting the proliferation and aggressiveness of neoplastic cells, facilitating malignant tumor cell diffusion, and mediating transcriptional silencing. Conclusion EZH2 mediated transcriptional repression through its methyltransferase activity at the chromatin level has certain influence on lymphoma, and there might exist a therapeutic window for the development of new agents and identification of novel diagnostic markers based on EZH2.</description><subject>Disease Progression</subject><subject>Enhancer of Zeste Homolog 2 Protein</subject><subject>Epigenesis, Genetic</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Lymphoma - etiology</subject><subject>Lymphoma - genetics</subject><subject>Methylation</subject><subject>Mutation</subject><subject>Polycomb Repressive Complex 2 - genetics</subject><subject>Polycomb Repressive Complex 2 - physiology</subject><subject>PubMed</subject><subject>同源基因</subject><subject>抑制机制</subject><subject>淋巴瘤</subject><subject>肿瘤发生</subject><subject>肿瘤细胞</subject><subject>转录抑制</subject><subject>过度</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90EtLxDAQAOAgiq6rf0HqRby0JpP3URZfIOxFzyVN022XNqnNrrr-eiOrXjJh-JgXQtcEF1QKfGMHU6yLLkZfYCpELrTWBWAC6Skw8AM0A84g54KRQzT7NyfoNMY1ToJLcYxOgGLJJWUzpJfvbnKf4-Ri7ILPQpM53xpv3fTz_3JxE7M2DKEPqwyyzmf9bhhTwpyho8b00Z3_xjl6vb97WTzmz8uHp8Xtc25BqE3ODVAOVcUk1owSLGqMpQWFQTWsBmuZYZgqXVtwhjtJudW24hIDUZpUNZ2jq33dD-Mb41flOmwnnzqWX60d1j_bQ9pMJHi9h-MU3rZp8HLoonV9b7wL21gSQqhWREtI9OKXbqvB1eU4dYOZduXfXRK43APbBr9661LbP8OowhQrRb8B4PVyFQ</recordid><startdate>20121020</startdate><enddate>20121020</enddate><creator>Guo, Shan-Qi</creator><creator>Zhang, Yi-Zhuo</creator><general>Department of Hematology and Blood and Marrow Transplantation, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20121020</creationdate><title>Overexpression of enhancer of zests homolog 2 in lymphoma</title><author>Guo, Shan-Qi ; Zhang, Yi-Zhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-5a2352bb470943106d007c28028f4d2cc4a40389dc2ea5e735c9cb57021891bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Disease Progression</topic><topic>Enhancer of Zeste Homolog 2 Protein</topic><topic>Epigenesis, Genetic</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Lymphoma - etiology</topic><topic>Lymphoma - genetics</topic><topic>Methylation</topic><topic>Mutation</topic><topic>Polycomb Repressive Complex 2 - genetics</topic><topic>Polycomb Repressive Complex 2 - physiology</topic><topic>PubMed</topic><topic>同源基因</topic><topic>抑制机制</topic><topic>淋巴瘤</topic><topic>肿瘤发生</topic><topic>肿瘤细胞</topic><topic>转录抑制</topic><topic>过度</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Shan-Qi</creatorcontrib><creatorcontrib>Zhang, Yi-Zhuo</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Shan-Qi</au><au>Zhang, Yi-Zhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of enhancer of zests homolog 2 in lymphoma</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2012-10-20</date><risdate>2012</risdate><volume>125</volume><issue>20</issue><spage>3735</spage><epage>3739</epage><pages>3735-3739</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Objective This article aimed to review the biological characteristics of enhancer of zests homolog 2 （EZH2）, and the transcriptional repression mechanism of action of EZH2 in tumors, particularly in the progression of lymphoma. Data sources The data cited in this review were mainly obtained from the articles listed in PubMed and HighWare that were published from March 2004 to April 2012. The search terms were ＂enhancer of zests homolog 2＂, ＂polycomb group＂, and ＂lymphoma＂. Study selection Articles regarding the mechanism of EZH2 in post-transcriptional modification, functions of polycomb group proteins, and the roles of EZH2 in lymphoma were selected. Results EZH2 acts as oncogene and involved in many kinds of tumors. Moreover, it plays an important role in tumorigenesis and lymphomagenesis by promoting the proliferation and aggressiveness of neoplastic cells, facilitating malignant tumor cell diffusion, and mediating transcriptional silencing. Conclusion EZH2 mediated transcriptional repression through its methyltransferase activity at the chromatin level has certain influence on lymphoma, and there might exist a therapeutic window for the development of new agents and identification of novel diagnostic markers based on EZH2.</abstract><cop>China</cop><pub>Department of Hematology and Blood and Marrow Transplantation, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China</pub><pmid>23075734</pmid><doi>10.3760/cma.j.issn.0366-6999.2012.20.025</doi><tpages>5</tpages></addata></record> |
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| subjects | Disease Progression Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic Histones - metabolism Humans Lymphoma - etiology Lymphoma - genetics Methylation Mutation Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - physiology PubMed 同源基因 抑制机制 淋巴瘤 肿瘤发生 肿瘤细胞 转录抑制 过度 |
| title | Overexpression of enhancer of zests homolog 2 in lymphoma |
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