Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation
Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver tr...
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| Veröffentlicht in: | Chinese medical journal 2012-08, Vol.125 (16), p.2841-2845 |
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| creator | Sha, Qing-Quan Wei, Qi-Zhen Zhu, Jian-Kang Wang, Ke-Xin Wang, Chao Liu, Hai-Tao Yu, Wen-Bin Li, Ming-Xia Zhang, Guang-Yong |
| description | Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver transplantation （LT） for HCC. Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients. The relationship between CEACAM1 expression and clinicopathologic variables, as well as tumor recurrence, was further analyzed. Results Of the 48 HCC specimens, membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens. Four specimens had loss of CEACAM1 expression. Loss of membranous CEACAM1 expression was significantly associated with tumor size, tumor number, and serum （z-fetoprotein levels （all P 〈0.05）. Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression, determined via Kaplan-Meier analysis （P=0.027）. Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation （P=0.037）. Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.2012.16.008 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_zhcmj201216008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>43323571</cqvip_id><wanfj_id>zhcmj201216008</wanfj_id><sourcerecordid>zhcmj201216008</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1838-2424224c93e8c4ababdb2b163369c40011e080100eacec6215bfa44ec12cdc7b3</originalsourceid><addsrcrecordid>eNo9kd1u1DAQhS0EokvhFZC5Qb1J8F-czSWq-JNW4gauo4kz2fXKsVM72ba8HW-Gw3arubDm6NPM8RxCbjgrZa3ZJzNCeSxtSr5kUutCN01TCsZFyXXJ2PYF2YhKiaLSir8km2fmirxJ6ciYqKpavyZXQjRSsLrekL-7kBINAx1x7CL4sCRqIBrrwyo8Bm8NBT_bPfoiooMZe2rQOQr9AZMNno7BoVkcUk7xYYqY_qs20Qs-B9qjiQgpN6s4JSyGiEjTEk_2BG41cMAJ5rCOXhzEi4kR6BCcC_fW76mzJ4x0zjbT5LIpmPOmt-TVAC7hu6f3mvz--uXX7fdi9_Pbj9vPu8LwrdwWQuUSyjQSt0ZBB13fiY5rKXVjFGOcI9syzhiCQaMFr7oBlELDhelN3clr8vE89x78AH7fHsMSfd7Y_jmY8bimwHXOIIM3Z3CK4W7BNLejTeu_wGM-b8tZzrJqVNVk9P0TunQj9u0U7Qjxsb3kk4EPZ8Acgt_f5SM8M0pKIauay3_Zsae9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1037659459</pqid></control><display><type>article</type><title>Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sha, Qing-Quan ; Wei, Qi-Zhen ; Zhu, Jian-Kang ; Wang, Ke-Xin ; Wang, Chao ; Liu, Hai-Tao ; Yu, Wen-Bin ; Li, Ming-Xia ; Zhang, Guang-Yong</creator><creatorcontrib>Sha, Qing-Quan ; Wei, Qi-Zhen ; Zhu, Jian-Kang ; Wang, Ke-Xin ; Wang, Chao ; Liu, Hai-Tao ; Yu, Wen-Bin ; Li, Ming-Xia ; Zhang, Guang-Yong</creatorcontrib><description>Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver transplantation （LT） for HCC. Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients. The relationship between CEACAM1 expression and clinicopathologic variables, as well as tumor recurrence, was further analyzed. Results Of the 48 HCC specimens, membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens. Four specimens had loss of CEACAM1 expression. Loss of membranous CEACAM1 expression was significantly associated with tumor size, tumor number, and serum （z-fetoprotein levels （all P 〈0.05）. Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression, determined via Kaplan-Meier analysis （P=0.027）. Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation （P=0.037）. Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2012.16.008</identifier><identifier>PMID: 22932077</identifier><language>eng</language><publisher>China: Department of Clinical Medicine, Shandong University School of Medicine, Jinan, Shandong 250012, China%Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China%First People's Hospital of Ningyang County, Tai'an, Shandong 271400, China%School of Chemistry, Shandong University, Jinan, Shandong 250012, China</publisher><subject>Adult ; Antigens, CD - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - surgery ; Cell Adhesion Molecules - metabolism ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Liver Neoplasms - metabolism ; Liver Neoplasms - mortality ; Liver Neoplasms - surgery ; Liver Transplantation ; Male ; Middle Aged ; 复发 ; 损失 ; 生存期 ; 癌胚抗原 ; 细胞黏附分子 ; 肝移植 ; 肝细胞肝癌 ; 膜</subject><ispartof>Chinese medical journal, 2012-08, Vol.125 (16), p.2841-2845</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22932077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sha, Qing-Quan</creatorcontrib><creatorcontrib>Wei, Qi-Zhen</creatorcontrib><creatorcontrib>Zhu, Jian-Kang</creatorcontrib><creatorcontrib>Wang, Ke-Xin</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Liu, Hai-Tao</creatorcontrib><creatorcontrib>Yu, Wen-Bin</creatorcontrib><creatorcontrib>Li, Ming-Xia</creatorcontrib><creatorcontrib>Zhang, Guang-Yong</creatorcontrib><title>Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver transplantation （LT） for HCC. Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients. The relationship between CEACAM1 expression and clinicopathologic variables, as well as tumor recurrence, was further analyzed. Results Of the 48 HCC specimens, membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens. Four specimens had loss of CEACAM1 expression. Loss of membranous CEACAM1 expression was significantly associated with tumor size, tumor number, and serum （z-fetoprotein levels （all P 〈0.05）. Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression, determined via Kaplan-Meier analysis （P=0.027）. Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation （P=0.037）. Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT.</description><subject>Adult</subject><subject>Antigens, CD - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>复发</subject><subject>损失</subject><subject>生存期</subject><subject>癌胚抗原</subject><subject>细胞黏附分子</subject><subject>肝移植</subject><subject>肝细胞肝癌</subject><subject>膜</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kd1u1DAQhS0EokvhFZC5Qb1J8F-czSWq-JNW4gauo4kz2fXKsVM72ba8HW-Gw3arubDm6NPM8RxCbjgrZa3ZJzNCeSxtSr5kUutCN01TCsZFyXXJ2PYF2YhKiaLSir8km2fmirxJ6ciYqKpavyZXQjRSsLrekL-7kBINAx1x7CL4sCRqIBrrwyo8Bm8NBT_bPfoiooMZe2rQOQr9AZMNno7BoVkcUk7xYYqY_qs20Qs-B9qjiQgpN6s4JSyGiEjTEk_2BG41cMAJ5rCOXhzEi4kR6BCcC_fW76mzJ4x0zjbT5LIpmPOmt-TVAC7hu6f3mvz--uXX7fdi9_Pbj9vPu8LwrdwWQuUSyjQSt0ZBB13fiY5rKXVjFGOcI9syzhiCQaMFr7oBlELDhelN3clr8vE89x78AH7fHsMSfd7Y_jmY8bimwHXOIIM3Z3CK4W7BNLejTeu_wGM-b8tZzrJqVNVk9P0TunQj9u0U7Qjxsb3kk4EPZ8Acgt_f5SM8M0pKIauay3_Zsae9</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Sha, Qing-Quan</creator><creator>Wei, Qi-Zhen</creator><creator>Zhu, Jian-Kang</creator><creator>Wang, Ke-Xin</creator><creator>Wang, Chao</creator><creator>Liu, Hai-Tao</creator><creator>Yu, Wen-Bin</creator><creator>Li, Ming-Xia</creator><creator>Zhang, Guang-Yong</creator><general>Department of Clinical Medicine, Shandong University School of Medicine, Jinan, Shandong 250012, China%Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China%First People's Hospital of Ningyang County, Tai'an, Shandong 271400, China%School of Chemistry, Shandong University, Jinan, Shandong 250012, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>201208</creationdate><title>Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation</title><author>Sha, Qing-Quan ; Wei, Qi-Zhen ; Zhu, Jian-Kang ; Wang, Ke-Xin ; Wang, Chao ; Liu, Hai-Tao ; Yu, Wen-Bin ; Li, Ming-Xia ; Zhang, Guang-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1838-2424224c93e8c4ababdb2b163369c40011e080100eacec6215bfa44ec12cdc7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Antigens, CD - metabolism</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>复发</topic><topic>损失</topic><topic>生存期</topic><topic>癌胚抗原</topic><topic>细胞黏附分子</topic><topic>肝移植</topic><topic>肝细胞肝癌</topic><topic>膜</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sha, Qing-Quan</creatorcontrib><creatorcontrib>Wei, Qi-Zhen</creatorcontrib><creatorcontrib>Zhu, Jian-Kang</creatorcontrib><creatorcontrib>Wang, Ke-Xin</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Liu, Hai-Tao</creatorcontrib><creatorcontrib>Yu, Wen-Bin</creatorcontrib><creatorcontrib>Li, Ming-Xia</creatorcontrib><creatorcontrib>Zhang, Guang-Yong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sha, Qing-Quan</au><au>Wei, Qi-Zhen</au><au>Zhu, Jian-Kang</au><au>Wang, Ke-Xin</au><au>Wang, Chao</au><au>Liu, Hai-Tao</au><au>Yu, Wen-Bin</au><au>Li, Ming-Xia</au><au>Zhang, Guang-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2012-08</date><risdate>2012</risdate><volume>125</volume><issue>16</issue><spage>2841</spage><epage>2845</epage><pages>2841-2845</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver transplantation （LT） for HCC. Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients. The relationship between CEACAM1 expression and clinicopathologic variables, as well as tumor recurrence, was further analyzed. Results Of the 48 HCC specimens, membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens. Four specimens had loss of CEACAM1 expression. Loss of membranous CEACAM1 expression was significantly associated with tumor size, tumor number, and serum （z-fetoprotein levels （all P 〈0.05）. Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression, determined via Kaplan-Meier analysis （P=0.027）. Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation （P=0.037）. Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT.</abstract><cop>China</cop><pub>Department of Clinical Medicine, Shandong University School of Medicine, Jinan, Shandong 250012, China%Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China%First People's Hospital of Ningyang County, Tai'an, Shandong 271400, China%School of Chemistry, Shandong University, Jinan, Shandong 250012, China</pub><pmid>22932077</pmid><doi>10.3760/cma.j.issn.0366-6999.2012.16.008</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Antigens, CD - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Cell Adhesion Molecules - metabolism Female Humans Immunohistochemistry Kaplan-Meier Estimate Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - surgery Liver Transplantation Male Middle Aged 复发 损失 生存期 癌胚抗原 细胞黏附分子 肝移植 肝细胞肝癌 膜 |
| title | Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation |
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