Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice
Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,
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| Veröffentlicht in: | Chinese medical journal 2011-04, Vol.124 (7), p.1075-1081 |
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| container_issue | 7 |
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| container_title | Chinese medical journal |
| container_volume | 124 |
| creator | Wang, Jin-Song Liu, Xia Xue, Zhen-Yi Alderman, Lee Tilan, Justin U Adenika, Remi Epstein, Stephen E Burnett, Mary Susan |
| description | Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization, |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.2011.07.023 |
| format | Article |
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We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2011.07.023</identifier><identifier>PMID: 21542971</identifier><language>eng</language><publisher>China: Division of Vascular Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China%Cardiovascular Research Institute,MedStar Health Research Institute,Washington DC,20010,USA</publisher><subject>Aging - physiology ; Animals ; Blotting, Western ; Chemokine CXCL12 - metabolism ; Female ; Hindlimb - metabolism ; Hindlimb - pathology ; Hindlimb - physiopathology ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Ischemia - metabolism ; Ischemia - physiopathology ; Matrix Metalloproteinase 9 - metabolism ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Necrosis - metabolism ; Necrosis - pathology ; Necrosis - physiopathology ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Neovascularization, Pathologic - physiopathology ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; Vascular Endothelial Growth Factor Receptor-1 - genetics ; Vascular Endothelial Growth Factor Receptor-1 - metabolism ; 基因表达 ; 小鼠 ; 急性 ; 新生血管形成 ; 时间 ; 缺血 ; 老化 ; 肢体</subject><ispartof>Chinese medical journal, 2011-04, Vol.124 (7), p.1075-1081</ispartof><rights>Copyright © Wanfang Data Co. 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All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21542971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jin-Song</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Xue, Zhen-Yi</creatorcontrib><creatorcontrib>Alderman, Lee</creatorcontrib><creatorcontrib>Tilan, Justin U</creatorcontrib><creatorcontrib>Adenika, Remi</creatorcontrib><creatorcontrib>Epstein, Stephen E</creatorcontrib><creatorcontrib>Burnett, Mary Susan</creatorcontrib><title>Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Blotting, Western</subject><subject>Chemokine CXCL12 - metabolism</subject><subject>Female</subject><subject>Hindlimb - metabolism</subject><subject>Hindlimb - pathology</subject><subject>Hindlimb - physiopathology</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Ischemia - metabolism</subject><subject>Ischemia - physiopathology</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Necrosis - metabolism</subject><subject>Necrosis - pathology</subject><subject>Necrosis - physiopathology</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Neovascularization, Pathologic - physiopathology</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - genetics</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - metabolism</subject><subject>基因表达</subject><subject>小鼠</subject><subject>急性</subject><subject>新生血管形成</subject><subject>时间</subject><subject>缺血</subject><subject>老化</subject><subject>肢体</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1u2zAQhImiQeOmfYWCuTS9SOU_pWMROG0AA7kkZ4GiVjINkXREKW799KHhNKcFBt_O7gxCPygpuVbkp_Wm3JUupVASrlSh6rouGaG0JLokjH9AKyYFK6QS9CNavTOX6HNKO0KYlFp9QpeMZqrWdIUO674HOycce2wGFwYcA56dB2zjMiU46QHii0l2Gc3kjmZ2MRQTjGaGDg8QAMPf_QQpZR33cRzj4WRj7DID3rrQjc632CW7Be8MdgF7Z-ELuujNmODr27xCT3frx9s_xebh9_3tr01hmdJzISTt27qmvGs556TrGChpdasrI0DLnE8rqQUDQTRRwtbKcFvJShPWC1CCX6HvZ9-DCb0JQ7PLsUK-2By31u9O3eVNxjN4cwb3U3xeIM2Nzz_DOJocf0lNpSStSaVIJr-9kUvroWv2k_Nm-tf8LzUD12fAbmMYnnMb7wzX2adSnL8ChvKJQw</recordid><startdate>20110405</startdate><enddate>20110405</enddate><creator>Wang, Jin-Song</creator><creator>Liu, Xia</creator><creator>Xue, Zhen-Yi</creator><creator>Alderman, Lee</creator><creator>Tilan, Justin U</creator><creator>Adenika, Remi</creator><creator>Epstein, Stephen E</creator><creator>Burnett, Mary Susan</creator><general>Division of Vascular Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China%Cardiovascular Research Institute,MedStar Health Research Institute,Washington DC,20010,USA</general><general>Cardiovascular Research Institute,MedStar Health Research Institute,Washington DC,20010,USA</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20110405</creationdate><title>Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice</title><author>Wang, Jin-Song ; 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We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,</abstract><cop>China</cop><pub>Division of Vascular Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China%Cardiovascular Research Institute,MedStar Health Research Institute,Washington DC,20010,USA</pub><pmid>21542971</pmid><doi>10.3760/cma.j.issn.0366-6999.2011.07.023</doi><tpages>7</tpages></addata></record> |
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| ispartof | Chinese medical journal, 2011-04, Vol.124 (7), p.1075-1081 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging - physiology Animals Blotting, Western Chemokine CXCL12 - metabolism Female Hindlimb - metabolism Hindlimb - pathology Hindlimb - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia - metabolism Ischemia - physiopathology Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Necrosis - metabolism Necrosis - pathology Necrosis - physiopathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism 基因表达 小鼠 急性 新生血管形成 时间 缺血 老化 肢体 |
| title | Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice |
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