Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice

Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,

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Veröffentlicht in:	Chinese medical journal 2011-04, Vol.124 (7), p.1075-1081
Hauptverfasser:	Wang, Jin-Song, Liu, Xia, Xue, Zhen-Yi, Alderman, Lee, Tilan, Justin U, Adenika, Remi, Epstein, Stephen E, Burnett, Mary Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Blotting, Western Chemokine CXCL12 - metabolism Female Hindlimb - metabolism Hindlimb - pathology Hindlimb - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia - metabolism Ischemia - physiopathology Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Necrosis - metabolism Necrosis - pathology Necrosis - physiopathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism 基因表达小鼠急性新生血管形成时间缺血老化肢体
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Zusammenfassung:	Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,
ISSN:	0366-6999 2542-5641
DOI:	10.3760/cma.j.issn.0366-6999.2011.07.023