Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism

Background Neuregulin-1 （NRG-1）, the ligand of the myocardial ErbB receptor, is a protein mediator with regulatory actions in the heart. This study investigated whether NRG-1 preconditioning has protective effects on myocardial ischemia/reperfusion （I/R） injury and its potential mechanism.Methods We...

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Veröffentlicht in:	Chinese medical journal 2010-12, Vol.123 (24), p.3597-3604
Hauptverfasser:	Fang, Shan-Juan, Wu, Xue-Si, Han, Zhi-Hong, Zhang, Xiao-Xia, Wang, Chun-Mei, Li, Xin-Yan, Lu, Ling-Qiao, Zhang, Jing-Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects caspase Caspase 3 - metabolism Dose-Response Relationship, Drug Ischemic Preconditioning, Myocardial L-Lactate Dehydrogenase - blood Male Myocardial Reperfusion Injury - prevention & control Neuregulin-1 - analysis Neuregulin-1 - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Phosphorylation Proto-Oncogene Proteins c-akt - physiology Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - analysis Receptor, ErbB-4 免疫印迹分析可能机制心肌缺血心脏功能缺血/再灌注损伤酸化预处理
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