Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP

Background Small cell lung cancer （SCLC） is the most aggressive form of lung cancer. This study aimed to investigate the mechanism of human small cell lung cancer cell line resistance to etoposide （VP-16）, H446NP. Methods The cell viability was measured by MTT assay. Immunocytochemistry, reverse tra...

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Veröffentlicht in:	Chinese medical journal 2010-11, Vol.123 (22), p.3299-3303
Hauptverfasser:	Wang, Yan-Ling, Yan, Yun-Li, Zhou, Na-Jing, Han, Shuo, Zhao, Jun-Xia, Cao, Cui-Li, Lü, Yu-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Blotting, Western Cell Line, Tumor DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Multiple - genetics Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - genetics Drug Resistance, Neoplasm - physiology Humans Immunohistochemistry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Small Cell Lung Carcinoma - metabolism 免疫细胞化学多药耐药基因拓扑异构酶细胞株耐药性耐药机制逆转录聚合酶链反应
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