Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury
Objective A general review was made of studies involving： （1） the concept and mechanism of the cholinergic anti-inflammatory pathway （CAP）, （2） the important role of inflammatory response in myocardial ischemia reperfusion （I/R） injury and （3） the evidence and mechanisms by which CAP may provide pro...
Gespeichert in:
| Veröffentlicht in: | Chinese medical journal 2010-10, Vol.123 (19), p.2720-2726 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2726 |
|---|---|
| container_issue | 19 |
| container_start_page | 2720 |
| container_title | Chinese medical journal |
| container_volume | 123 |
| creator | Xiong, Jun Xue, Fu-shan Yuan, Yu-jing Wang, Qiang Liao, Xu Wang, Wei-li |
| description | Objective A general review was made of studies involving： （1） the concept and mechanism of the cholinergic anti-inflammatory pathway （CAP）, （2） the important role of inflammatory response in myocardial ischemia reperfusion （I/R） injury and （3） the evidence and mechanisms by which CAP may provide protection against myocardial I/R injury. Data sources The data used in this review were mainly from manuscripts listed in PubMed that were published in English from 1987 to 2009. The search terms were ＂vagal nerve stimulation＂, ＂myocardial ischemia reperfusion injury＂, ＂nicotine acetylcholine receptor＂ and ＂inflammation＂. Study selection （1） Clinical and experimental evidence that the inflammatory response induced by reperfusion enhances myocardial I/R injury. （2） Clinical and laboratory evidence that the CAP inhibits the inflammation and provides protection against myocardial I/R injury. Results The myocardial I/R injury is really an inflammatory process characterized by recruitment of neutrophils into the ischemic myocardium and excessive production of pro-inflammatory cytokines. Because the CAP can modulate the inflammatory response by decreasing the production and release of pro-inflammatory cytokines, it can provide protection against myocardial I/R injury. Conclusions The CAP can inhibit the inflammatory response induced by reperfusion and protect against myocardial I/R injury. It represents an exciting opportunity to develop new and novel therapeutics to attenuate the myocardial I/R injury. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.2010.19.019 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_zhcmj201019019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>35910456</cqvip_id><wanfj_id>zhcmj201019019</wanfj_id><sourcerecordid>zhcmj201019019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-1e4a7812d24157224a4ea19035dbc4ad3b69752f2434d28dfd858ce9e9e002d93</originalsourceid><addsrcrecordid>eNo9kM1u1TAQhS0EoreFV0AWC-gmwf-Jl-iKP6kSG1hHE8e5cUjs1E5ahUfhWXgnXgFXt6BZzEjz6cycg9A1JSWvFHlnZijH0qXkS8KVKpTWumQkr6kuCdVP0IFJwQqpBH2KDv-ZC3SZ0kgIk7JSz9EFo4QLJfUB3R2HMDlv48kZDH51hfP9BPMMa4g7XmAd7mH_8_sXBryElFw7WQzLEgOYAa8B52m1ZsVwAufTiuc9GIidgwm7ZAY7O8DRLjb2W3LBY-fHLe4v0LMepmRfPvYr9P3jh2_Hz8XN109fju9vCsNUvRbUCqhqyjomqKwYEyAsUE247FojoOOt0pVkPRNcdKzu-q6WtbE6VzbbaX6F3px178H34E_NGLbo88Xm52Dm8SG6LEcfwLdnMPu53Wxamzm_b6cJvA1bairFCCc1IZl89Uhu7Wy7Zoluhrg3_zLNwOszYIbgT7cuX23B_OjdZBsuNSVCKv4XskGL-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>762030800</pqid></control><display><type>article</type><title>Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Xiong, Jun ; Xue, Fu-shan ; Yuan, Yu-jing ; Wang, Qiang ; Liao, Xu ; Wang, Wei-li</creator><creatorcontrib>Xiong, Jun ; Xue, Fu-shan ; Yuan, Yu-jing ; Wang, Qiang ; Liao, Xu ; Wang, Wei-li</creatorcontrib><description>Objective A general review was made of studies involving： （1） the concept and mechanism of the cholinergic anti-inflammatory pathway （CAP）, （2） the important role of inflammatory response in myocardial ischemia reperfusion （I/R） injury and （3） the evidence and mechanisms by which CAP may provide protection against myocardial I/R injury. Data sources The data used in this review were mainly from manuscripts listed in PubMed that were published in English from 1987 to 2009. The search terms were ＂vagal nerve stimulation＂, ＂myocardial ischemia reperfusion injury＂, ＂nicotine acetylcholine receptor＂ and ＂inflammation＂. Study selection （1） Clinical and experimental evidence that the inflammatory response induced by reperfusion enhances myocardial I/R injury. （2） Clinical and laboratory evidence that the CAP inhibits the inflammation and provides protection against myocardial I/R injury. Results The myocardial I/R injury is really an inflammatory process characterized by recruitment of neutrophils into the ischemic myocardium and excessive production of pro-inflammatory cytokines. Because the CAP can modulate the inflammatory response by decreasing the production and release of pro-inflammatory cytokines, it can provide protection against myocardial I/R injury. Conclusions The CAP can inhibit the inflammatory response induced by reperfusion and protect against myocardial I/R injury. It represents an exciting opportunity to develop new and novel therapeutics to attenuate the myocardial I/R injury.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2010.19.019</identifier><identifier>PMID: 21034659</identifier><language>eng</language><publisher>China: Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144, China</publisher><subject>Animals ; Cytokines - metabolism ; Humans ; Inflammation - immunology ; Models, Biological ; Myocardial Reperfusion Injury - immunology ; Myocardial Reperfusion Injury - metabolism ; Myocardial Reperfusion Injury - prevention & control ; PubMed ; Vagus Nerve Stimulation ; 实验证据 ; 心肌缺血再灌注 ; 炎性细胞因子 ; 炎症反应 ; 缺血再灌注损伤 ; 胆碱能</subject><ispartof>Chinese medical journal, 2010-10, Vol.123 (19), p.2720-2726</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,778,782,862,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21034659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiong, Jun</creatorcontrib><creatorcontrib>Xue, Fu-shan</creatorcontrib><creatorcontrib>Yuan, Yu-jing</creatorcontrib><creatorcontrib>Wang, Qiang</creatorcontrib><creatorcontrib>Liao, Xu</creatorcontrib><creatorcontrib>Wang, Wei-li</creatorcontrib><title>Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Objective A general review was made of studies involving： （1） the concept and mechanism of the cholinergic anti-inflammatory pathway （CAP）, （2） the important role of inflammatory response in myocardial ischemia reperfusion （I/R） injury and （3） the evidence and mechanisms by which CAP may provide protection against myocardial I/R injury. Data sources The data used in this review were mainly from manuscripts listed in PubMed that were published in English from 1987 to 2009. The search terms were ＂vagal nerve stimulation＂, ＂myocardial ischemia reperfusion injury＂, ＂nicotine acetylcholine receptor＂ and ＂inflammation＂. Study selection （1） Clinical and experimental evidence that the inflammatory response induced by reperfusion enhances myocardial I/R injury. （2） Clinical and laboratory evidence that the CAP inhibits the inflammation and provides protection against myocardial I/R injury. Results The myocardial I/R injury is really an inflammatory process characterized by recruitment of neutrophils into the ischemic myocardium and excessive production of pro-inflammatory cytokines. Because the CAP can modulate the inflammatory response by decreasing the production and release of pro-inflammatory cytokines, it can provide protection against myocardial I/R injury. Conclusions The CAP can inhibit the inflammatory response induced by reperfusion and protect against myocardial I/R injury. It represents an exciting opportunity to develop new and novel therapeutics to attenuate the myocardial I/R injury.</description><subject>Animals</subject><subject>Cytokines - metabolism</subject><subject>Humans</subject><subject>Inflammation - immunology</subject><subject>Models, Biological</subject><subject>Myocardial Reperfusion Injury - immunology</subject><subject>Myocardial Reperfusion Injury - metabolism</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>PubMed</subject><subject>Vagus Nerve Stimulation</subject><subject>实验证据</subject><subject>心肌缺血再灌注</subject><subject>炎性细胞因子</subject><subject>炎症反应</subject><subject>缺血再灌注损伤</subject><subject>胆碱能</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1u1TAQhS0EoreFV0AWC-gmwf-Jl-iKP6kSG1hHE8e5cUjs1E5ahUfhWXgnXgFXt6BZzEjz6cycg9A1JSWvFHlnZijH0qXkS8KVKpTWumQkr6kuCdVP0IFJwQqpBH2KDv-ZC3SZ0kgIk7JSz9EFo4QLJfUB3R2HMDlv48kZDH51hfP9BPMMa4g7XmAd7mH_8_sXBryElFw7WQzLEgOYAa8B52m1ZsVwAufTiuc9GIidgwm7ZAY7O8DRLjb2W3LBY-fHLe4v0LMepmRfPvYr9P3jh2_Hz8XN109fju9vCsNUvRbUCqhqyjomqKwYEyAsUE247FojoOOt0pVkPRNcdKzu-q6WtbE6VzbbaX6F3px178H34E_NGLbo88Xm52Dm8SG6LEcfwLdnMPu53Wxamzm_b6cJvA1bairFCCc1IZl89Uhu7Wy7Zoluhrg3_zLNwOszYIbgT7cuX23B_OjdZBsuNSVCKv4XskGL-A</recordid><startdate>20101005</startdate><enddate>20101005</enddate><creator>Xiong, Jun</creator><creator>Xue, Fu-shan</creator><creator>Yuan, Yu-jing</creator><creator>Wang, Qiang</creator><creator>Liao, Xu</creator><creator>Wang, Wei-li</creator><general>Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20101005</creationdate><title>Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury</title><author>Xiong, Jun ; Xue, Fu-shan ; Yuan, Yu-jing ; Wang, Qiang ; Liao, Xu ; Wang, Wei-li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-1e4a7812d24157224a4ea19035dbc4ad3b69752f2434d28dfd858ce9e9e002d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cytokines - metabolism</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Models, Biological</topic><topic>Myocardial Reperfusion Injury - immunology</topic><topic>Myocardial Reperfusion Injury - metabolism</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>PubMed</topic><topic>Vagus Nerve Stimulation</topic><topic>实验证据</topic><topic>心肌缺血再灌注</topic><topic>炎性细胞因子</topic><topic>炎症反应</topic><topic>缺血再灌注损伤</topic><topic>胆碱能</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiong, Jun</creatorcontrib><creatorcontrib>Xue, Fu-shan</creatorcontrib><creatorcontrib>Yuan, Yu-jing</creatorcontrib><creatorcontrib>Wang, Qiang</creatorcontrib><creatorcontrib>Liao, Xu</creatorcontrib><creatorcontrib>Wang, Wei-li</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiong, Jun</au><au>Xue, Fu-shan</au><au>Yuan, Yu-jing</au><au>Wang, Qiang</au><au>Liao, Xu</au><au>Wang, Wei-li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2010-10-05</date><risdate>2010</risdate><volume>123</volume><issue>19</issue><spage>2720</spage><epage>2726</epage><pages>2720-2726</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Objective A general review was made of studies involving： （1） the concept and mechanism of the cholinergic anti-inflammatory pathway （CAP）, （2） the important role of inflammatory response in myocardial ischemia reperfusion （I/R） injury and （3） the evidence and mechanisms by which CAP may provide protection against myocardial I/R injury. Data sources The data used in this review were mainly from manuscripts listed in PubMed that were published in English from 1987 to 2009. The search terms were ＂vagal nerve stimulation＂, ＂myocardial ischemia reperfusion injury＂, ＂nicotine acetylcholine receptor＂ and ＂inflammation＂. Study selection （1） Clinical and experimental evidence that the inflammatory response induced by reperfusion enhances myocardial I/R injury. （2） Clinical and laboratory evidence that the CAP inhibits the inflammation and provides protection against myocardial I/R injury. Results The myocardial I/R injury is really an inflammatory process characterized by recruitment of neutrophils into the ischemic myocardium and excessive production of pro-inflammatory cytokines. Because the CAP can modulate the inflammatory response by decreasing the production and release of pro-inflammatory cytokines, it can provide protection against myocardial I/R injury. Conclusions The CAP can inhibit the inflammatory response induced by reperfusion and protect against myocardial I/R injury. It represents an exciting opportunity to develop new and novel therapeutics to attenuate the myocardial I/R injury.</abstract><cop>China</cop><pub>Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144, China</pub><pmid>21034659</pmid><doi>10.3760/cma.j.issn.0366-6999.2010.19.019</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2010-10, Vol.123 (19), p.2720-2726 |
| issn | 0366-6999 2542-5641 |
| language | eng |
| recordid | cdi_wanfang_journals_zhcmj201019019 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cytokines - metabolism Humans Inflammation - immunology Models, Biological Myocardial Reperfusion Injury - immunology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control PubMed Vagus Nerve Stimulation 实验证据 心肌缺血再灌注 炎性细胞因子 炎症反应 缺血再灌注损伤 胆碱能 |
| title | Cholinergic anti-inflammatory pathway： a possible approach to protect against myocardial ischemia reperfusion injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T05%3A22%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cholinergic%20anti-inflammatory%20pathway%EF%BC%9A%20a%20possible%20approach%20to%20protect%20against%20myocardial%20ischemia%20reperfusion%20injury&rft.jtitle=Chinese%20medical%20journal&rft.au=Xiong,%20Jun&rft.date=2010-10-05&rft.volume=123&rft.issue=19&rft.spage=2720&rft.epage=2726&rft.pages=2720-2726&rft.issn=0366-6999&rft.eissn=2542-5641&rft_id=info:doi/10.3760/cma.j.issn.0366-6999.2010.19.019&rft_dat=%3Cwanfang_jour_proqu%3Ezhcmj201019019%3C/wanfang_jour_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=762030800&rft_id=info:pmid/21034659&rft_cqvip_id=35910456&rft_wanfj_id=zhcmj201019019&rfr_iscdi=true |