Overexpression of leptin and leptin receptors in breast cancer positively correlates with clinicopathological features
Obesity has been reported to increase postmenopausal breast cancer risk by 30% to 50%, and obese breast cancer patients have been shown to present more aggressive breast cancer pathological features As most breast cancers are sex hormone-dependent, adipocytokines derived from adipose tissue, such as...
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| Veröffentlicht in: | Chinese medical journal 2009-12, Vol.122 (24), p.3078-3081 |
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| container_end_page | 3081 |
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| container_issue | 24 |
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| container_title | Chinese medical journal |
| container_volume | 122 |
| creator | Xia, Xiang-Hou Gu, Jun-Chao Bai, Qing-Yang Yu, Wei |
| description | Obesity has been reported to increase postmenopausal breast cancer risk by 30% to 50%, and obese breast cancer patients have been shown to present more aggressive breast cancer pathological features As most breast cancers are sex hormone-dependent, adipocytokines derived from adipose tissue, such as leptin, may account for the positive association between obesity and breast cancer. Leptin, a 16-kDa protein product of the obese gene, was initially regarded as a neuroendocrine factor in the hypothalamus to maintain homeostasis of body weight by regulating food intake and energy expenditure. |
| doi_str_mv | 10.3760/cma.j.issn.0366-6999.2009.24.031 |
| format | Article |
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Leptin, a 16-kDa protein product of the obese gene, was initially regarded as a neuroendocrine factor in the hypothalamus to maintain homeostasis of body weight by regulating food intake and energy expenditure.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2009.24.031</identifier><identifier>PMID: 20137505</identifier><language>eng</language><publisher>China: Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China%Department of General Surgery, the First Hospital Affiliated to Baotou Medical College, Baotou, Inner Mongolia 014010, China</publisher><subject>Adult ; Aged ; Breast Neoplasms - complications ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Female ; Humans ; Immunohistochemistry ; Leptin - metabolism ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Receptors, Leptin - metabolism ; 乳腺癌 ; 病理特征 ; 神经内分泌 ; 肥胖基因</subject><ispartof>Chinese medical journal, 2009-12, Vol.122 (24), p.3078-3081</ispartof><rights>Copyright © Wanfang Data Co. 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| fulltext | fulltext |
| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2009-12, Vol.122 (24), p.3078-3081 |
| issn | 0366-6999 2542-5641 |
| language | eng |
| recordid | cdi_wanfang_journals_zhcmj200924031 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Breast Neoplasms - complications Breast Neoplasms - metabolism Breast Neoplasms - pathology Female Humans Immunohistochemistry Leptin - metabolism Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Receptors, Leptin - metabolism 乳腺癌 病理特征 神经内分泌 肥胖基因 |
| title | Overexpression of leptin and leptin receptors in breast cancer positively correlates with clinicopathological features |
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