Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation

Background Neuroprotective strategies following cardiopulmonary resuscitation （CPR） are an important focus in emergency and critical care medicine. Matrix metalloproteinases （MMPs）, especially MMP9 attracted much attention because of its function in focal brain ischemia/reperfusion injury. In the fo...

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Veröffentlicht in:	Chinese medical journal 2009-10, Vol.122 (19), p.2346-2351
Hauptverfasser:	He, Zhi-jie, Huang, Zi-tong, Chen, Xiao-tong, Zou, Zi-jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - drug effects Brain - immunology Brain - ultrastructure Cardiopulmonary Resuscitation Cytokines - analysis Heterocyclic Compounds, 1-Ring - pharmacology Inflammation - prevention & control Male Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase Inhibitors Neuroprotective Agents - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - analysis Sulfones - pharmacology
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