Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus
Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study ana...
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| Veröffentlicht in: | Chinese medical journal 2008-07, Vol.121 (13), p.1165-1168 |
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| creator | Du, Jian-ling Sun, Chang-kai Lü, Bo Men, Li-li Yao, Jun-jie An, Li-jia Song, Gui-rong |
| description | Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level.
Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）.
Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.
Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis. |
| doi_str_mv | 10.1097/00029330-200807010-00003 |
| format | Article |
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Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）.
Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.
Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200807010-00003</identifier><identifier>PMID: 18710632</identifier><language>eng</language><publisher>China: Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China</publisher><subject>2型糖尿病 ; Adipose Tissue - metabolism ; Adult ; Aged ; Base Sequence ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Humans ; Insulin Resistance ; Male ; Membrane Proteins - genetics ; Molecular Sequence Data ; Omentum - metabolism ; RNA, Messenger - analysis ; Selenoproteins - genetics ; Serum Amyloid A Protein - analysis ; 治疗方法 ; 胰岛素抗性 ; 血清抗体A</subject><ispartof>Chinese medical journal, 2008-07, Vol.121 (13), p.1165-1168</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-2588be4519c78fb8766b7215da1a8c1f88525ee87b936c125ba26d3eee2b71dc3</citedby><cites>FETCH-LOGICAL-c421t-2588be4519c78fb8766b7215da1a8c1f88525ee87b936c125ba26d3eee2b71dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18710632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Jian-ling</creatorcontrib><creatorcontrib>Sun, Chang-kai</creatorcontrib><creatorcontrib>Lü, Bo</creatorcontrib><creatorcontrib>Men, Li-li</creatorcontrib><creatorcontrib>Yao, Jun-jie</creatorcontrib><creatorcontrib>An, Li-jia</creatorcontrib><creatorcontrib>Song, Gui-rong</creatorcontrib><title>Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level.
Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）.
Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.
Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.</description><subject>2型糖尿病</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>Omentum - metabolism</subject><subject>RNA, Messenger - analysis</subject><subject>Selenoproteins - genetics</subject><subject>Serum Amyloid A Protein - analysis</subject><subject>治疗方法</subject><subject>胰岛素抗性</subject><subject>血清抗体A</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd1u1DAQhS1ERZfCKyCLC-4C_on_LlcVpZUqKrVwbTnOpOsljtM4UVmegMfGy27bq5FmvnNmNAchTMlnSoz6QghhhnNSMUI0UYSSqrQIf4VWTNSsErKmr9GKcCkraYw5RW9z3haREEq-QadUK0okZyv0d51z8sHNIQ04dfgO-jscb7-vMfweJ8h53w9lFGGYXY9dG8aUAc8h5wXwY5g3-DJFV13dYje0OMO0ROzirk-hxeu9dCzmRZwP8LwbATPcBtfADBlH6PswL_kdOulcn-H9sZ6hnxdff5xfVtc3367O19eVrxmdKya0bqAW1Hilu0YrKRvFqGgdddrTTmvBBIBWjeHSUyYax2TLAYA1iraen6FPB99HN3RuuLfbtExD2Wj_bHzc7h9KeXnlCzhO6WGBPNsYsi_XugHSkq00dU01YwXUB9BPKecJOjtOIbppZymx-7jsU1z2OS77P64i_XDcsTQR2hfhMZ8CfDx6b9Jw_xDKvY3zv7rQg2WqOBlq-D9ya5vV</recordid><startdate>20080705</startdate><enddate>20080705</enddate><creator>Du, Jian-ling</creator><creator>Sun, Chang-kai</creator><creator>Lü, Bo</creator><creator>Men, Li-li</creator><creator>Yao, Jun-jie</creator><creator>An, Li-jia</creator><creator>Song, Gui-rong</creator><general>Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China</general><general>Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China%Institute of Brain Disorders and Key Lab for Brain Disorders of Liaoning Province,Dalian Medical University,Dalian,Liaoning 116044,China%Department of Endocrinology,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China%Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China%Department of Health Statistics,Dalian Medical University,Dalian,Liaoning 116044,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20080705</creationdate><title>Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus</title><author>Du, Jian-ling ; Sun, Chang-kai ; Lü, Bo ; Men, Li-li ; Yao, Jun-jie ; An, Li-jia ; Song, Gui-rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-2588be4519c78fb8766b7215da1a8c1f88525ee87b936c125ba26d3eee2b71dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>2型糖尿病</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Base Sequence</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>Omentum - metabolism</topic><topic>RNA, Messenger - analysis</topic><topic>Selenoproteins - genetics</topic><topic>Serum Amyloid A Protein - analysis</topic><topic>治疗方法</topic><topic>胰岛素抗性</topic><topic>血清抗体A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Jian-ling</creatorcontrib><creatorcontrib>Sun, Chang-kai</creatorcontrib><creatorcontrib>Lü, Bo</creatorcontrib><creatorcontrib>Men, Li-li</creatorcontrib><creatorcontrib>Yao, Jun-jie</creatorcontrib><creatorcontrib>An, Li-jia</creatorcontrib><creatorcontrib>Song, Gui-rong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Jian-ling</au><au>Sun, Chang-kai</au><au>Lü, Bo</au><au>Men, Li-li</au><au>Yao, Jun-jie</au><au>An, Li-jia</au><au>Song, Gui-rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2008-07-05</date><risdate>2008</risdate><volume>121</volume><issue>13</issue><spage>1165</spage><epage>1168</epage><pages>1165-1168</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background Tanis was reported as a putative receptor for serum amyloid A （SAA） involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats （Psammomys obesus, Israeli sand rat） and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus （T2DM）, and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level.
Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction （PCR）, Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay （ELISA）.
Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.
Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.</abstract><cop>China</cop><pub>Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian,Liaoning 116023,China</pub><pmid>18710632</pmid><doi>10.1097/00029330-200807010-00003</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2008-07, Vol.121 (13), p.1165-1168 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 2型糖尿病 Adipose Tissue - metabolism Adult Aged Base Sequence Diabetes Mellitus, Type 2 - metabolism Female Humans Insulin Resistance Male Membrane Proteins - genetics Molecular Sequence Data Omentum - metabolism RNA, Messenger - analysis Selenoproteins - genetics Serum Amyloid A Protein - analysis 治疗方法 胰岛素抗性 血清抗体A |
| title | Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus |
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