Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study
Background Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion （BPA）, fluorine-18^fluorodeoxyglucos...
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| Veröffentlicht in: | Chinese medical journal 2008-06, Vol.121 (12), p.1096-1100 |
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| creator | Chen, Fu-yong Tao, Wei Cheng, Xin Wang, Hong-yan Hu, Yong-sheng Zhang, Xiao-hua Li, Yong-jie |
| description | Background Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion （BPA）, fluorine-18^fluorodeoxyglucose （18^F-FDG） positron emission tomography （PET） scanning was applied to determine the glucose metabolic changes in patients with pain due to BPA.
Methods Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the 18^F-FDG PET study. The patients were rated by visual analog scale （VAS） during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 （SPM2） was applied for data analysis.
Results Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI （P 〈0.001, uncorrected）, and significant glucose metabolism increases in the right orbitofrontal cortex （OFC） （BAll）, left rostral insula cortex and left dorsolateral prefrontal cortex （DLPFC） （BA10/46） （P 〈0.001, uncorrected）.
Conclusion These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA. |
| doi_str_mv | 10.1097/00029330-200806020-00011 |
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Methods Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the 18^F-FDG PET study. The patients were rated by visual analog scale （VAS） during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 （SPM2） was applied for data analysis.
Results Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI （P 〈0.001, uncorrected）, and significant glucose metabolism increases in the right orbitofrontal cortex （OFC） （BAll）, left rostral insula cortex and left dorsolateral prefrontal cortex （DLPFC） （BA10/46） （P 〈0.001, uncorrected）.
Conclusion These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200806020-00011</identifier><identifier>PMID: 18706225</identifier><language>eng</language><publisher>China: Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China%Positron Emission Tomography Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China%Beijing Institute of Functional Neurosurgery,Posiwon Emission Tomography Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China</publisher><subject>Adult ; Brachial Plexus - injuries ; Brain - metabolism ; Chronic Disease ; Female ; Glucose - metabolism ; Humans ; Male ; Middle Aged ; Pain - etiology ; Pain - physiopathology ; Pain Measurement ; Positron-Emission Tomography - methods ; Prefrontal Cortex - metabolism ; Thalamus - metabolism ; 治疗方法 ; 神经疼痛 ; 神经网络 ; 阳电子发射</subject><ispartof>Chinese medical journal, 2008-06, Vol.121 (12), p.1096-1100</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-5e47d38683a2fe641cc8848677d342e1da4a71c9b9f626e5435b33e4666d80e53</citedby><cites>FETCH-LOGICAL-c421t-5e47d38683a2fe641cc8848677d342e1da4a71c9b9f626e5435b33e4666d80e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18706225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Fu-yong</creatorcontrib><creatorcontrib>Tao, Wei</creatorcontrib><creatorcontrib>Cheng, Xin</creatorcontrib><creatorcontrib>Wang, Hong-yan</creatorcontrib><creatorcontrib>Hu, Yong-sheng</creatorcontrib><creatorcontrib>Zhang, Xiao-hua</creatorcontrib><creatorcontrib>Li, Yong-jie</creatorcontrib><title>Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion （BPA）, fluorine-18^fluorodeoxyglucose （18^F-FDG） positron emission tomography （PET） scanning was applied to determine the glucose metabolic changes in patients with pain due to BPA.
Methods Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the 18^F-FDG PET study. The patients were rated by visual analog scale （VAS） during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 （SPM2） was applied for data analysis.
Results Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI （P 〈0.001, uncorrected）, and significant glucose metabolism increases in the right orbitofrontal cortex （OFC） （BAll）, left rostral insula cortex and left dorsolateral prefrontal cortex （DLPFC） （BA10/46） （P 〈0.001, uncorrected）.
Conclusion These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA.</description><subject>Adult</subject><subject>Brachial Plexus - injuries</subject><subject>Brain - metabolism</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Positron-Emission Tomography - methods</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Thalamus - metabolism</subject><subject>治疗方法</subject><subject>神经疼痛</subject><subject>神经网络</subject><subject>阳电子发射</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUcuO1DAQtBCIHRZ-AVkcuAX8TnKEFS9pJS5wthynM_Hg2Fk7YRk-BfEp_BO_gMMM7Kml7qrq6i6EMCUvKGnrl4QQ1nJOKkZIQxRhpCotSu-hHZOCVVIJeh_tCFeqUm3bXqBHOR8KScpaPUQXtKmJYkzu0M_XybiA9361MQOeYDFd9M5iO5qwh4xNztE6s0CPb90yln6KoczzHMNiAsQ143mT6FfAS8RdMnZ0xuPZw7cyM19Xn10Mv3_9wAbPCbybXDDpiOeY3VLEMEwub5BCn-I-mXk84rys_fExejAYn-HJuV6iz2_ffLp6X11_fPfh6tV1ZQWjSyVB1D1vVMMNG6Ccbm3TiEbVpSsY0N4IU1Pbdu2gmAIpuOw4B6GU6hsCkl-i5yfdWxOGcrY-xDWFslF_H-102J5MWXnvHXBO8WaFvOhi3YL3p0do1QpejLACbE5Am2LOCQY9JzeVqzUleotQ_4tQ_49Q_42wUJ-ed6zdBP0d8ZxZATw7a48x7G9c8dsZ-2VwHjSrlWSb7h-UXqbH</recordid><startdate>20080620</startdate><enddate>20080620</enddate><creator>Chen, Fu-yong</creator><creator>Tao, Wei</creator><creator>Cheng, Xin</creator><creator>Wang, Hong-yan</creator><creator>Hu, Yong-sheng</creator><creator>Zhang, Xiao-hua</creator><creator>Li, Yong-jie</creator><general>Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China%Positron Emission Tomography Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China%Beijing Institute of Functional Neurosurgery,Posiwon Emission Tomography Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20080620</creationdate><title>Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study</title><author>Chen, Fu-yong ; Tao, Wei ; Cheng, Xin ; Wang, Hong-yan ; Hu, Yong-sheng ; Zhang, Xiao-hua ; Li, Yong-jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-5e47d38683a2fe641cc8848677d342e1da4a71c9b9f626e5435b33e4666d80e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Brachial Plexus - injuries</topic><topic>Brain - metabolism</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Positron-Emission Tomography - methods</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Thalamus - metabolism</topic><topic>治疗方法</topic><topic>神经疼痛</topic><topic>神经网络</topic><topic>阳电子发射</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Fu-yong</creatorcontrib><creatorcontrib>Tao, Wei</creatorcontrib><creatorcontrib>Cheng, Xin</creatorcontrib><creatorcontrib>Wang, Hong-yan</creatorcontrib><creatorcontrib>Hu, Yong-sheng</creatorcontrib><creatorcontrib>Zhang, Xiao-hua</creatorcontrib><creatorcontrib>Li, Yong-jie</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Fu-yong</au><au>Tao, Wei</au><au>Cheng, Xin</au><au>Wang, Hong-yan</au><au>Hu, Yong-sheng</au><au>Zhang, Xiao-hua</au><au>Li, Yong-jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2008-06-20</date><risdate>2008</risdate><volume>121</volume><issue>12</issue><spage>1096</spage><epage>1100</epage><pages>1096-1100</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion （BPA）, fluorine-18^fluorodeoxyglucose （18^F-FDG） positron emission tomography （PET） scanning was applied to determine the glucose metabolic changes in patients with pain due to BPA.
Methods Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the 18^F-FDG PET study. The patients were rated by visual analog scale （VAS） during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 （SPM2） was applied for data analysis.
Results Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI （P 〈0.001, uncorrected）, and significant glucose metabolism increases in the right orbitofrontal cortex （OFC） （BAll）, left rostral insula cortex and left dorsolateral prefrontal cortex （DLPFC） （BA10/46） （P 〈0.001, uncorrected）.
Conclusion These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA.</abstract><cop>China</cop><pub>Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China%Positron Emission Tomography Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China%Beijing Institute of Functional Neurosurgery,Posiwon Emission Tomography Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China</pub><pmid>18706225</pmid><doi>10.1097/00029330-200806020-00011</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Brachial Plexus - injuries Brain - metabolism Chronic Disease Female Glucose - metabolism Humans Male Middle Aged Pain - etiology Pain - physiopathology Pain Measurement Positron-Emission Tomography - methods Prefrontal Cortex - metabolism Thalamus - metabolism 治疗方法 神经疼痛 神经网络 阳电子发射 |
| title | Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion： a preliminary positron emission tomography study |
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