Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus
Background This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula （Diason low energy： 313.8 k J/100 ml）, compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid （FFA） in type 2 diabetic...
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| Veröffentlicht in: | Chinese medical journal 2008-04, Vol.121 (8), p.691-695 |
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| creator | Li, Yu-xiu Zeng, Jing-bo Yu, Kang Sun, Qi Liu, Qiu-ying Qin, Wei Zhang, Qian Yu, Jian-chun Wang, Heng |
| description | Background This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula （Diason low energy： 313.8 k J/100 ml）, compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid （FFA） in type 2 diabetics.
Methods In total of 71 type 2 diabetics completed the study. Enteral formulas were given orally as the sole source of nutrition to the subjects for 6 days. Venous blood samples （0.5, 1, 2, 3 hours） were collected at day -7 after a 75 g oral glucose tolerance test （OGTT）, day 1 after a standard test meal （1673.6 k J） and after 6 days of either the test diabetes specific formula or a standard formula. Plasma glucose, serum insulin, C peptide and lipids were.measured.
Results After the intervention period, the diabetes specific formula resulted in a significantly lower postprandial rise in blood glucose concentrations at 0.5 hour （P 〈0.05） and 1 hour （P 〈0.01）; significantly lower peak height of plasma glucose （P=0.05）; significantly lower plasma insulin concentrations at 0.5 hour （P〈0.01）, 1 hour （P〈0.01） and 2 hours （P 〈0.01）; and a significantly lower plasma insulin peak compared to controls; both OGTT and a standard test meal （P 〈0.05）. The glucose and insulin area under the curve after the diabetes specific formula compared to the standard formula were significantly lower. The C peptide level was lower after 6 days of both nutrition formulas compare to 75 g OGTT, but not different from the standard mixed meal. Both formulas were well tolerated.
Conclusions In summary the diabetes specific formula with a relatively high monounsaturated fatty acid and high multi fiber proportion significantly improved glycemic control. On top of this, the insulin sensitivity （HOMA-IS） was significantly improved and may therefore directly improve the impact on long term complications. The disease specific formula should therefore be the preferred option to be used by diabetic and hyperglycemic patients in need of nutritional support. |
| doi_str_mv | 10.1097/00029330-200804020-00006 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_zhcmj200808005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>27053148</cqvip_id><wanfj_id>zhcmj200808005</wanfj_id><sourcerecordid>zhcmj200808005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-968a462bd94685136e0204ddf634b637fa3ab918dbbd5d01b2f5c13f00b7face3</originalsourceid><addsrcrecordid>eNpFkUtv1DAUhS0EotPCX0AWC3Yp1484yRKq8pAqsYG15cd1x0PiTGOHavgB_G7cdmBWlu3vnHvsQwhlcMlg6N4DAB-EgIYD9CCBQ1OPQD0jG95K3rRKsudkA0KpRg3DcEbOc95VUdt26iU5Y30HrKo25M9HTBiii2akGAK6kukcqKE-GosFM817dLESNMzLtI6GzonGlNcxJpox5Vjir1gO1CRPw4JIgykPWxd95ejelIiput7HsqXlsEfKT-YTjmMsa35FXgQzZnx9XC_Ij0_X36--NDffPn-9-nDTOMlZaQbVG6m49YNUfcuEwvoI6X1QQlolumCEsQPrvbW-9cAsD61jIgDYeudQXJB3T773JgWTbvVuXpdUJ-rfWzftHr-zB2hP4H6Z71bMRU8xu5rWJJzXrNUgedfLroL9E-iWOecFg94vcTLLQTPQD2Xpf2Xp_2Xpx7Kq9M1xxmon9CfhsZ0KvD16b-d0exdrXmvczxBH1LyrKZnsxV-t15xQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69427847</pqid></control><display><type>article</type><title>Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Li, Yu-xiu ; Zeng, Jing-bo ; Yu, Kang ; Sun, Qi ; Liu, Qiu-ying ; Qin, Wei ; Zhang, Qian ; Yu, Jian-chun ; Wang, Heng</creator><creatorcontrib>Li, Yu-xiu ; Zeng, Jing-bo ; Yu, Kang ; Sun, Qi ; Liu, Qiu-ying ; Qin, Wei ; Zhang, Qian ; Yu, Jian-chun ; Wang, Heng</creatorcontrib><description>Background This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula （Diason low energy： 313.8 k J/100 ml）, compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid （FFA） in type 2 diabetics.
Methods In total of 71 type 2 diabetics completed the study. Enteral formulas were given orally as the sole source of nutrition to the subjects for 6 days. Venous blood samples （0.5, 1, 2, 3 hours） were collected at day -7 after a 75 g oral glucose tolerance test （OGTT）, day 1 after a standard test meal （1673.6 k J） and after 6 days of either the test diabetes specific formula or a standard formula. Plasma glucose, serum insulin, C peptide and lipids were.measured.
Results After the intervention period, the diabetes specific formula resulted in a significantly lower postprandial rise in blood glucose concentrations at 0.5 hour （P 〈0.05） and 1 hour （P 〈0.01）; significantly lower peak height of plasma glucose （P=0.05）; significantly lower plasma insulin concentrations at 0.5 hour （P〈0.01）, 1 hour （P〈0.01） and 2 hours （P 〈0.01）; and a significantly lower plasma insulin peak compared to controls; both OGTT and a standard test meal （P 〈0.05）. The glucose and insulin area under the curve after the diabetes specific formula compared to the standard formula were significantly lower. The C peptide level was lower after 6 days of both nutrition formulas compare to 75 g OGTT, but not different from the standard mixed meal. Both formulas were well tolerated.
Conclusions In summary the diabetes specific formula with a relatively high monounsaturated fatty acid and high multi fiber proportion significantly improved glycemic control. On top of this, the insulin sensitivity （HOMA-IS） was significantly improved and may therefore directly improve the impact on long term complications. The disease specific formula should therefore be the preferred option to be used by diabetic and hyperglycemic patients in need of nutritional support.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200804020-00006</identifier><identifier>PMID: 18701020</identifier><language>eng</language><publisher>China: Department of Endocrinology,Key Laboratory of Endocrinology,Ministry of Health Peking Union Medical College Hospital,Beijing 100730,China%Department of Nutrition Peking Union Medical College Hospital,Beijing 100730,China%Department of Employee Health Care Peking Union Medical College Hospital,Beijing 100730,China%Department of General Surgery Peking Union Medical College Hospital,Beijing 100730,China</publisher><subject>2型糖尿病 ; C-Peptide - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diet therapy ; Diet, Diabetic ; Fatty Acids, Nonesterified - blood ; Humans ; Insulin - metabolism ; Insulin Secretion ; Lipids - blood ; Middle Aged ; Prospective Studies ; 游离脂肪酸 ; 胰岛素敏感性 ; 血糖控制</subject><ispartof>Chinese medical journal, 2008-04, Vol.121 (8), p.691-695</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-968a462bd94685136e0204ddf634b637fa3ab918dbbd5d01b2f5c13f00b7face3</citedby><cites>FETCH-LOGICAL-c421t-968a462bd94685136e0204ddf634b637fa3ab918dbbd5d01b2f5c13f00b7face3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18701020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yu-xiu</creatorcontrib><creatorcontrib>Zeng, Jing-bo</creatorcontrib><creatorcontrib>Yu, Kang</creatorcontrib><creatorcontrib>Sun, Qi</creatorcontrib><creatorcontrib>Liu, Qiu-ying</creatorcontrib><creatorcontrib>Qin, Wei</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Yu, Jian-chun</creatorcontrib><creatorcontrib>Wang, Heng</creatorcontrib><title>Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula （Diason low energy： 313.8 k J/100 ml）, compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid （FFA） in type 2 diabetics.
Methods In total of 71 type 2 diabetics completed the study. Enteral formulas were given orally as the sole source of nutrition to the subjects for 6 days. Venous blood samples （0.5, 1, 2, 3 hours） were collected at day -7 after a 75 g oral glucose tolerance test （OGTT）, day 1 after a standard test meal （1673.6 k J） and after 6 days of either the test diabetes specific formula or a standard formula. Plasma glucose, serum insulin, C peptide and lipids were.measured.
Results After the intervention period, the diabetes specific formula resulted in a significantly lower postprandial rise in blood glucose concentrations at 0.5 hour （P 〈0.05） and 1 hour （P 〈0.01）; significantly lower peak height of plasma glucose （P=0.05）; significantly lower plasma insulin concentrations at 0.5 hour （P〈0.01）, 1 hour （P〈0.01） and 2 hours （P 〈0.01）; and a significantly lower plasma insulin peak compared to controls; both OGTT and a standard test meal （P 〈0.05）. The glucose and insulin area under the curve after the diabetes specific formula compared to the standard formula were significantly lower. The C peptide level was lower after 6 days of both nutrition formulas compare to 75 g OGTT, but not different from the standard mixed meal. Both formulas were well tolerated.
Conclusions In summary the diabetes specific formula with a relatively high monounsaturated fatty acid and high multi fiber proportion significantly improved glycemic control. On top of this, the insulin sensitivity （HOMA-IS） was significantly improved and may therefore directly improve the impact on long term complications. The disease specific formula should therefore be the preferred option to be used by diabetic and hyperglycemic patients in need of nutritional support.</description><subject>2型糖尿病</subject><subject>C-Peptide - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - diet therapy</subject><subject>Diet, Diabetic</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Lipids - blood</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>游离脂肪酸</subject><subject>胰岛素敏感性</subject><subject>血糖控制</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAUhS0EotPCX0AWC3Yp1484yRKq8pAqsYG15cd1x0PiTGOHavgB_G7cdmBWlu3vnHvsQwhlcMlg6N4DAB-EgIYD9CCBQ1OPQD0jG95K3rRKsudkA0KpRg3DcEbOc95VUdt26iU5Y30HrKo25M9HTBiii2akGAK6kukcqKE-GosFM817dLESNMzLtI6GzonGlNcxJpox5Vjir1gO1CRPw4JIgykPWxd95ejelIiput7HsqXlsEfKT-YTjmMsa35FXgQzZnx9XC_Ij0_X36--NDffPn-9-nDTOMlZaQbVG6m49YNUfcuEwvoI6X1QQlolumCEsQPrvbW-9cAsD61jIgDYeudQXJB3T773JgWTbvVuXpdUJ-rfWzftHr-zB2hP4H6Z71bMRU8xu5rWJJzXrNUgedfLroL9E-iWOecFg94vcTLLQTPQD2Xpf2Xp_2Xpx7Kq9M1xxmon9CfhsZ0KvD16b-d0exdrXmvczxBH1LyrKZnsxV-t15xQ</recordid><startdate>20080420</startdate><enddate>20080420</enddate><creator>Li, Yu-xiu</creator><creator>Zeng, Jing-bo</creator><creator>Yu, Kang</creator><creator>Sun, Qi</creator><creator>Liu, Qiu-ying</creator><creator>Qin, Wei</creator><creator>Zhang, Qian</creator><creator>Yu, Jian-chun</creator><creator>Wang, Heng</creator><general>Department of Endocrinology,Key Laboratory of Endocrinology,Ministry of Health Peking Union Medical College Hospital,Beijing 100730,China%Department of Nutrition Peking Union Medical College Hospital,Beijing 100730,China%Department of Employee Health Care Peking Union Medical College Hospital,Beijing 100730,China%Department of General Surgery Peking Union Medical College Hospital,Beijing 100730,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20080420</creationdate><title>Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus</title><author>Li, Yu-xiu ; Zeng, Jing-bo ; Yu, Kang ; Sun, Qi ; Liu, Qiu-ying ; Qin, Wei ; Zhang, Qian ; Yu, Jian-chun ; Wang, Heng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-968a462bd94685136e0204ddf634b637fa3ab918dbbd5d01b2f5c13f00b7face3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>2型糖尿病</topic><topic>C-Peptide - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - diet therapy</topic><topic>Diet, Diabetic</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Lipids - blood</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>游离脂肪酸</topic><topic>胰岛素敏感性</topic><topic>血糖控制</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yu-xiu</creatorcontrib><creatorcontrib>Zeng, Jing-bo</creatorcontrib><creatorcontrib>Yu, Kang</creatorcontrib><creatorcontrib>Sun, Qi</creatorcontrib><creatorcontrib>Liu, Qiu-ying</creatorcontrib><creatorcontrib>Qin, Wei</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Yu, Jian-chun</creatorcontrib><creatorcontrib>Wang, Heng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yu-xiu</au><au>Zeng, Jing-bo</au><au>Yu, Kang</au><au>Sun, Qi</au><au>Liu, Qiu-ying</au><au>Qin, Wei</au><au>Zhang, Qian</au><au>Yu, Jian-chun</au><au>Wang, Heng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2008-04-20</date><risdate>2008</risdate><volume>121</volume><issue>8</issue><spage>691</spage><epage>695</epage><pages>691-695</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula （Diason low energy： 313.8 k J/100 ml）, compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid （FFA） in type 2 diabetics.
Methods In total of 71 type 2 diabetics completed the study. Enteral formulas were given orally as the sole source of nutrition to the subjects for 6 days. Venous blood samples （0.5, 1, 2, 3 hours） were collected at day -7 after a 75 g oral glucose tolerance test （OGTT）, day 1 after a standard test meal （1673.6 k J） and after 6 days of either the test diabetes specific formula or a standard formula. Plasma glucose, serum insulin, C peptide and lipids were.measured.
Results After the intervention period, the diabetes specific formula resulted in a significantly lower postprandial rise in blood glucose concentrations at 0.5 hour （P 〈0.05） and 1 hour （P 〈0.01）; significantly lower peak height of plasma glucose （P=0.05）; significantly lower plasma insulin concentrations at 0.5 hour （P〈0.01）, 1 hour （P〈0.01） and 2 hours （P 〈0.01）; and a significantly lower plasma insulin peak compared to controls; both OGTT and a standard test meal （P 〈0.05）. The glucose and insulin area under the curve after the diabetes specific formula compared to the standard formula were significantly lower. The C peptide level was lower after 6 days of both nutrition formulas compare to 75 g OGTT, but not different from the standard mixed meal. Both formulas were well tolerated.
Conclusions In summary the diabetes specific formula with a relatively high monounsaturated fatty acid and high multi fiber proportion significantly improved glycemic control. On top of this, the insulin sensitivity （HOMA-IS） was significantly improved and may therefore directly improve the impact on long term complications. The disease specific formula should therefore be the preferred option to be used by diabetic and hyperglycemic patients in need of nutritional support.</abstract><cop>China</cop><pub>Department of Endocrinology,Key Laboratory of Endocrinology,Ministry of Health Peking Union Medical College Hospital,Beijing 100730,China%Department of Nutrition Peking Union Medical College Hospital,Beijing 100730,China%Department of Employee Health Care Peking Union Medical College Hospital,Beijing 100730,China%Department of General Surgery Peking Union Medical College Hospital,Beijing 100730,China</pub><pmid>18701020</pmid><doi>10.1097/00029330-200804020-00006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2008-04, Vol.121 (8), p.691-695 |
| issn | 0366-6999 2542-5641 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 2型糖尿病 C-Peptide - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diet therapy Diet, Diabetic Fatty Acids, Nonesterified - blood Humans Insulin - metabolism Insulin Secretion Lipids - blood Middle Aged Prospective Studies 游离脂肪酸 胰岛素敏感性 血糖控制 |
| title | Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus |
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