The effect of celecoxib on tissue factor expression in pancreatic cancer cells

Tissue factor (TF) is overexpressed in many malignant tumours and is linked to the pathogenesis and prognosis of such malignancies. In vitro studies have proved that reduced expression of TF has inhibitory effect on the angiogenesis and cell proliferation of the malignant tumour. Therefore, TF suppr...

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Veröffentlicht in:	Chinese medical journal 2007-10, Vol.120 (20), p.1753-1756
Hauptverfasser:	Wang, Hui-yuan, Yang, Yin-mo, Zhuang, Yan, Chen, Huan-nian, Wan, Yuan-lian, Huang, Yan-ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Celecoxib Cell Line, Tumor Cyclooxygenase 2 Inhibitors - pharmacology Gene Expression Regulation - drug effects Humans NF-kappa B - metabolism Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pyrazoles - pharmacology Sulfonamides - pharmacology Thromboplastin - genetics Tumor Necrosis Factor-alpha - antagonists & inhibitors
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