Modulation of KCNQ1 current by atrial fibrillation-associated KCNE4 (145E/D) gene polymorphism

Atrial fibrillation is a common arrhythmia with multi-factorial pathogenesis. Recently, a single nucleotide polymorphism (G/T) at position 1057 in the KCNE4 gene, resulting in a glutamic acid (Glu, E)/aspartic acid (Asp, D) substitution at position 145 of the KCNE4 peptide, was found in our laborato...

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Veröffentlicht in:Chinese medical journal 2007-01, Vol.120 (2), p.150-154
Hauptverfasser: Ma, Ke-juan, Li, Ning, Teng, Si-yong, Zhang, Yin-hui, Sun, Qi, Gu, Dong-feng, Pu, Jie-lin
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Sprache:eng
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