Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats

Background The RhoA/Rho kinase pathway may participate in the pathogenesis of hypoxia and monocrotaline induced pulmonary hypertension. This study tested whether RhoA/Rho kinase pathway is involved in the pathogenesis of high flow induced pulmonary hypertension in rats. Methods Male Wistar rats （4 w...

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Veröffentlicht in:	Chinese medical journal 2007-01, Vol.120 (1), p.22-29
Hauptverfasser:	Li, Fu-Hai, Xia, Wei, Li, Ai-Wu, Zhao, Cui-Fen, Sun, Ruo-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use Animals Cell Proliferation - drug effects Enzyme Activation - drug effects Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertrophy, Right Ventricular - prevention & control Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - physiology Male Muscle, Smooth, Vascular - drug effects Protein Kinase Inhibitors - therapeutic use Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - physiology Pulmonary Artery - pathology Pulmonary Circulation - drug effects Rats Rats, Wistar rho-Associated Kinases rhoA GTP-Binding Protein - physiology Systole - drug effects Vasoconstriction - drug effects 肺动脉高血压肺循环肺部疾病
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