Pro-apoptotic effect of cecropin AD on nasopharyngeal carcinoma cells
Nasopharyngeal carcinoma （NPC） is one of the highly prevalent malignancies in Southeast Asia. Chemotherapy and radiotherapy are commonly administrated to treat nasopharyngeal carcinoma, but these therapies can not prevent the recurrence and metastasis of tumor cells. Furthermore, these therapies hav...
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| Veröffentlicht in: | Chinese medical journal 2006-06, Vol.119 (12), p.1042-1046 |
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| creator | Xiao, Ye-chen Huang, Ya-dong Xu, Pei-lin Zhou, Zhen-qing Li, Xiao-kun |
| description | Nasopharyngeal carcinoma （NPC） is one of the highly prevalent malignancies in Southeast Asia. Chemotherapy and radiotherapy are commonly administrated to treat nasopharyngeal carcinoma, but these therapies can not prevent the recurrence and metastasis of tumor cells. Furthermore, these therapies have severe side effects. Therefore, it is important to find a more effective therapy, e. g., a gene therapy for treatment of nasopharyngeal carcinoma. Cecropin AD （Cad） is a hybrid peptide that exhibits higher antibacterial activity than natural cecropin. It consists of 1-11 amino acid residues in the N-end of cecropin A and 12-37 amino acid residues in the c-end of cecropin D. The role of Cad in the malignant cells remains unclear. In this study, the Cad gene was cloned and transferred into NPC CNE2 cells and its pro-apoptotic effect were investigated. |
| doi_str_mv | 10.1097/00029330-200606020-00014 |
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Chemotherapy and radiotherapy are commonly administrated to treat nasopharyngeal carcinoma, but these therapies can not prevent the recurrence and metastasis of tumor cells. Furthermore, these therapies have severe side effects. Therefore, it is important to find a more effective therapy, e. g., a gene therapy for treatment of nasopharyngeal carcinoma. Cecropin AD （Cad） is a hybrid peptide that exhibits higher antibacterial activity than natural cecropin. It consists of 1-11 amino acid residues in the N-end of cecropin A and 12-37 amino acid residues in the c-end of cecropin D. The role of Cad in the malignant cells remains unclear. In this study, the Cad gene was cloned and transferred into NPC CNE2 cells and its pro-apoptotic effect were investigated.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200606020-00014</identifier><identifier>PMID: 16805991</identifier><language>eng</language><publisher>China: Biotechnology Research Center,Key Laboratory of Gene Engineering,Ministry of Education,Sun Yat-sen University,Guangzhou 510275,China%Biopharmaceutical Research & Development Center,Jinan University,Guangzhou 510632,China%Department of Zoology,Miami University,Oxford 45056,USA%School of Pharmaceutical Sciences,Wenzhou Medical College,Wenzhou 325035,China</publisher><subject>Animals ; Apoptosis ; Cell Line, Tumor ; Flow Cytometry ; Genetic Therapy ; Humans ; Insect Proteins - genetics ; Mice ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - therapy ; NIH 3T3 Cells ; Plasmids ; 杀菌肽 ; 细胞凋亡 ; 肿瘤细胞 ; 鼻咽癌</subject><ispartof>Chinese medical journal, 2006-06, Vol.119 (12), p.1042-1046</ispartof><rights>Copyright © Wanfang Data Co. 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Chemotherapy and radiotherapy are commonly administrated to treat nasopharyngeal carcinoma, but these therapies can not prevent the recurrence and metastasis of tumor cells. Furthermore, these therapies have severe side effects. Therefore, it is important to find a more effective therapy, e. g., a gene therapy for treatment of nasopharyngeal carcinoma. Cecropin AD （Cad） is a hybrid peptide that exhibits higher antibacterial activity than natural cecropin. It consists of 1-11 amino acid residues in the N-end of cecropin A and 12-37 amino acid residues in the c-end of cecropin D. The role of Cad in the malignant cells remains unclear. In this study, the Cad gene was cloned and transferred into NPC CNE2 cells and its pro-apoptotic effect were investigated.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell Line, Tumor</subject><subject>Flow Cytometry</subject><subject>Genetic Therapy</subject><subject>Humans</subject><subject>Insect Proteins - genetics</subject><subject>Mice</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - therapy</subject><subject>NIH 3T3 Cells</subject><subject>Plasmids</subject><subject>杀菌肽</subject><subject>细胞凋亡</subject><subject>肿瘤细胞</subject><subject>鼻咽癌</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqXwCyhiwS4wfsSJlxWUh1QJFrC2HNduUxI7jRMh-HpcWqhmMdLo3rkzB6EEww0Gkd8CABGUQkoAeCwCaRxhdoTGJGMkzTjDx2gMlPOUCyFG6CyEdTRlWc5P0QjzAjIh8BjNXjufqta3ve8rnRhrje4TbxNtdOfbyiXT-8S7xKng25XqvtzSqDrRqtOV842KuroO5-jEqjqYi32foPeH2dvdUzp_eXy-m85TzQjuUwNKWBKjNYaFEAA6twXlBkqeccOIVoozaoFhzK0WuS45E5pQwTQwZQSdoOvd3k_lrHJLufZD52Ki_F7pZr2lgUnkcBC2nd8MJvSyqcL2VOWMH4LkRVYwmhdRWOyE8dsQOmNl21VN_FNikFvW8o-1_Gctf1lH6-U-YygbszgY93Cj4Gq_e-XdclPFe0ulP2xVG0kIjvE4oz_bHYN0</recordid><startdate>20060620</startdate><enddate>20060620</enddate><creator>Xiao, Ye-chen</creator><creator>Huang, Ya-dong</creator><creator>Xu, Pei-lin</creator><creator>Zhou, Zhen-qing</creator><creator>Li, Xiao-kun</creator><general>Biotechnology Research Center,Key Laboratory of Gene Engineering,Ministry of Education,Sun Yat-sen University,Guangzhou 510275,China%Biopharmaceutical Research & Development Center,Jinan University,Guangzhou 510632,China%Department of Zoology,Miami University,Oxford 45056,USA%School of Pharmaceutical Sciences,Wenzhou Medical College,Wenzhou 325035,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20060620</creationdate><title>Pro-apoptotic effect of cecropin AD on nasopharyngeal carcinoma cells</title><author>Xiao, Ye-chen ; 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Chemotherapy and radiotherapy are commonly administrated to treat nasopharyngeal carcinoma, but these therapies can not prevent the recurrence and metastasis of tumor cells. Furthermore, these therapies have severe side effects. Therefore, it is important to find a more effective therapy, e. g., a gene therapy for treatment of nasopharyngeal carcinoma. Cecropin AD （Cad） is a hybrid peptide that exhibits higher antibacterial activity than natural cecropin. It consists of 1-11 amino acid residues in the N-end of cecropin A and 12-37 amino acid residues in the c-end of cecropin D. The role of Cad in the malignant cells remains unclear. 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| subjects | Animals Apoptosis Cell Line, Tumor Flow Cytometry Genetic Therapy Humans Insect Proteins - genetics Mice Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - therapy NIH 3T3 Cells Plasmids 杀菌肽 细胞凋亡 肿瘤细胞 鼻咽癌 |
| title | Pro-apoptotic effect of cecropin AD on nasopharyngeal carcinoma cells |
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