Age-related decrease in expression of peroxisome proliferator-activated receptor α and its effects on development of dyslipidemia

Background Ageing is associated with increased incidence of dyslipidemia. To investigate potential molecular mechanisms, the effects of age and fibrate administration on peroxisome proliferator-activated receptor α(PPARα) expression in livers of young and old rats were studied.Methods A total of 16...

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Veröffentlicht in:	Chinese medical journal 2005-07, Vol.118 (13), p.1093-1098
Hauptverfasser:	Ye, Ping, Wang, Zhao-jun, Zhang, Xiu-jin, Zhao, Ya-li
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Fenofibrate - pharmacology Fenofibrate - therapeutic use Hyperlipidemias - drug therapy Hyperlipidemias - etiology Lipids - blood Liver - metabolism Male PPAR alpha - genetics Rats Rats, Sprague-Dawley 脂质代谢药物治疗过氧物酶体酶活性
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