Protective effect of propofol at clinically relevant concentrations on primary cultured newborn rat hippocampus
Some basic experiments in vivo have confirmed that propofol is capable of providing neuroprotection. Using cultured neurons,interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions coul...
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| Veröffentlicht in: | Chinese medical journal 2005-04, Vol.118 (7), p.603-605 |
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| creator | Zhu, Bin Ye, Tie-hu Zhao, Jin-xian |
| description | Some basic experiments in vivo have confirmed that propofol is capable of providing neuroprotection. Using cultured neurons,interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions could be observed.Evenso, there are not many in vitro experiments about propofol' s neuroprotection and only two are about anoxia of hippocampal slices and culturedhippocampal neurons. |
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Using cultured neurons,interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions could be observed.Evenso, there are not many in vitro experiments about propofol' s neuroprotection and only two are about anoxia of hippocampal slices and culturedhippocampal neurons.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>PMID: 15820094</identifier><language>eng</language><publisher>China: Department of Anaesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China%Department of Endocrinology, First Affiliated Hospital of Hebei Medical University, Shijiazhuang 050031, China</publisher><subject>Animals ; Animals, Newborn ; Cell Hypoxia ; Cell Survival - drug effects ; Female ; Hippocampus - cytology ; Hippocampus - drug effects ; L-Lactate Dehydrogenase - secretion ; Male ; Malondialdehyde - analysis ; Neuroprotective Agents - pharmacology ; Propofol - pharmacology ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; 丙泊酚 ; 保护机制 ; 动物实验 ; 大脑海马区</subject><ispartof>Chinese medical journal, 2005-04, Vol.118 (7), p.603-605</ispartof><rights>Copyright © Wanfang Data Co. 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Using cultured neurons,interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions could be observed.Evenso, there are not many in vitro experiments about propofol' s neuroprotection and only two are about anoxia of hippocampal slices and culturedhippocampal neurons.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cell Hypoxia</subject><subject>Cell Survival - drug effects</subject><subject>Female</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>L-Lactate Dehydrogenase - secretion</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Propofol - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>丙泊酚</subject><subject>保护机制</subject><subject>动物实验</subject><subject>大脑海马区</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAQx4so7vr4ChI8eCukaR7tUcQXCHrQc5nMTt2sadLtQ9FPb2BXPM0w_Gb-_OYgWwolRa60LA6zJS-1znVd14vsZBw3nAuljD7OFoWqBOe1XGbxZYgT4eQ-iVHbpo7FlvVD7GMbPYOJoXfBIXj_zQby9AkhzWJACtMAk4thZDGkDdfB8M1w9tM80IoF-rJxCCwxbO36PiJ0_TyeZUct-JHO9_U0e7u7fb15yJ-e7x9vrp9yFNpMecm5hcICoNWSDIGpoFgJqQxXYCvQtShAKNRoqkoL25agK2sRaSWlRlGeZle7u18QWgjvzSbOQ0iJzc8au02yV9zwQv6DyXk70zg1nRuRvIdAcR4bbYwQO_BiD862o1WzN27-fpmAyx2A6xjety6FWsCP1nlKkCxrrevyF1BPf0k</recordid><startdate>20050405</startdate><enddate>20050405</enddate><creator>Zhu, Bin</creator><creator>Ye, Tie-hu</creator><creator>Zhao, Jin-xian</creator><general>Department of Anaesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China%Department of Endocrinology, First Affiliated Hospital of Hebei Medical University, Shijiazhuang 050031, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20050405</creationdate><title>Protective effect of propofol at clinically relevant concentrations on primary cultured newborn rat hippocampus</title><author>Zhu, Bin ; 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| ispartof | Chinese medical journal, 2005-04, Vol.118 (7), p.603-605 |
| issn | 0366-6999 2542-5641 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn Cell Hypoxia Cell Survival - drug effects Female Hippocampus - cytology Hippocampus - drug effects L-Lactate Dehydrogenase - secretion Male Malondialdehyde - analysis Neuroprotective Agents - pharmacology Propofol - pharmacology Rats Rats, Wistar Superoxide Dismutase - metabolism 丙泊酚 保护机制 动物实验 大脑海马区 |
| title | Protective effect of propofol at clinically relevant concentrations on primary cultured newborn rat hippocampus |
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