Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study
To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM). Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese w...
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| Veröffentlicht in: | Chinese medical journal 2003-05, Vol.116 (5), p.777-780 |
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| creator | Lin, Jun Zhang, Xinmei Qian, Yuli Ye, Yinghui Shi, Yifu Xu, Kaihong Xu, Jianyun |
| description | To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM).
Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese women with endometriosis and 28 without endometriosis.
The frequencies of GSTM1 and GSTT1 null genotypes in women with endometriosis were 0.721 (49/68) and 0.779 (53/68), respectively, and in women without endometriosis were 0.429 (12/28) and 0.321 (9/28), respectively. There was a significant difference with regard to the frequencies of GSTM1 and GSTT1 null genotypes between the women with and without endometriosis (P < 0.01). Furthermore, the frequencies of GSTM1 and GSTT1 null genotypes were significantly higher in the patients with stage III and IV endometriosis [0.731 (38/52) and 0.788 (41/52), respectively] than in women without endometriosis (P < 0.01), and the frequency of GSTT1 null genotype was statistically higher in patients with stage I and II endometriosis [0.75 (12/16)] than in the women without endometriosis (P < 0.01). No correlation between GSTM1 and GSTT1 null genotypes and age, induced abortion or dysmenorrhea was detected in this study (P > 0.05).
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis. |
| format | Article |
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Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese women with endometriosis and 28 without endometriosis.
The frequencies of GSTM1 and GSTT1 null genotypes in women with endometriosis were 0.721 (49/68) and 0.779 (53/68), respectively, and in women without endometriosis were 0.429 (12/28) and 0.321 (9/28), respectively. There was a significant difference with regard to the frequencies of GSTM1 and GSTT1 null genotypes between the women with and without endometriosis (P < 0.01). Furthermore, the frequencies of GSTM1 and GSTT1 null genotypes were significantly higher in the patients with stage III and IV endometriosis [0.731 (38/52) and 0.788 (41/52), respectively] than in women without endometriosis (P < 0.01), and the frequency of GSTT1 null genotype was statistically higher in patients with stage I and II endometriosis [0.75 (12/16)] than in the women without endometriosis (P < 0.01). No correlation between GSTM1 and GSTT1 null genotypes and age, induced abortion or dysmenorrhea was detected in this study (P > 0.05).
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.</description><identifier>ISSN: 0366-6999</identifier><identifier>PMID: 12875700</identifier><language>eng</language><publisher>China: Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China</publisher><subject>Adult ; Case-Control Studies ; Endometriosis - enzymology ; Endometriosis - genetics ; Endometriosis - pathology ; Female ; Genotype ; Glutathione Transferase - genetics ; Humans ; Risk Factors</subject><ispartof>Chinese medical journal, 2003-05, Vol.116 (5), p.777-780</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zhcmj/zhcmj.jpg</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12875700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Jun</creatorcontrib><creatorcontrib>Zhang, Xinmei</creatorcontrib><creatorcontrib>Qian, Yuli</creatorcontrib><creatorcontrib>Ye, Yinghui</creatorcontrib><creatorcontrib>Shi, Yifu</creatorcontrib><creatorcontrib>Xu, Kaihong</creatorcontrib><creatorcontrib>Xu, Jianyun</creatorcontrib><title>Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study</title><title>Chinese medical journal</title><addtitle>Chin Med J (Engl)</addtitle><description>To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM).
Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese women with endometriosis and 28 without endometriosis.
The frequencies of GSTM1 and GSTT1 null genotypes in women with endometriosis were 0.721 (49/68) and 0.779 (53/68), respectively, and in women without endometriosis were 0.429 (12/28) and 0.321 (9/28), respectively. There was a significant difference with regard to the frequencies of GSTM1 and GSTT1 null genotypes between the women with and without endometriosis (P < 0.01). Furthermore, the frequencies of GSTM1 and GSTT1 null genotypes were significantly higher in the patients with stage III and IV endometriosis [0.731 (38/52) and 0.788 (41/52), respectively] than in women without endometriosis (P < 0.01), and the frequency of GSTT1 null genotype was statistically higher in patients with stage I and II endometriosis [0.75 (12/16)] than in the women without endometriosis (P < 0.01). No correlation between GSTM1 and GSTT1 null genotypes and age, induced abortion or dysmenorrhea was detected in this study (P > 0.05).
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Endometriosis - enzymology</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - pathology</subject><subject>Female</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Risk Factors</subject><issn>0366-6999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFOwzAQRH0A0VL4BeQTt0hOXMcJN1RBQSriQDmiyFmv24TEDrYjVL6eCIo4jTR6M7uaEzJnPM-TvCzLGTkPoWUsE0LmZ2SWZoUUkrE5eVt3Y1Rx3ziL9CWJXtlg0KuA9Cmlymq6TekOrYuHAcOPgVa7HqNvXGgC9U14v6GKwhRJwNnoXdehpiGO-nBBTo3qAl4edUFe7--2q4dk87x-XN1ukiEVnCdFDlxzKI00RoIGk0GtVSo0lNOfUMgaRLGsDdZYgzZQM6MzjTJXKCQvlnxBrn97P5U1yu6q1o3eTherrz30bcYYZ4Jx_g8O3n2MGGLVNwGw65RFN4ZKcsFSycQEXh3Bse5RV4NveuUP1d9y_BvmeGr4</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Lin, Jun</creator><creator>Zhang, Xinmei</creator><creator>Qian, Yuli</creator><creator>Ye, Yinghui</creator><creator>Shi, Yifu</creator><creator>Xu, Kaihong</creator><creator>Xu, Jianyun</creator><general>Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20030501</creationdate><title>Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study</title><author>Lin, Jun ; Zhang, Xinmei ; Qian, Yuli ; Ye, Yinghui ; Shi, Yifu ; Xu, Kaihong ; Xu, Jianyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1533-86c3d3c9f7ff7cdcf2cbda15dc9875c87bc584bfebebcdfcb0fd2de76ae573843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Endometriosis - enzymology</topic><topic>Endometriosis - genetics</topic><topic>Endometriosis - pathology</topic><topic>Female</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Jun</creatorcontrib><creatorcontrib>Zhang, Xinmei</creatorcontrib><creatorcontrib>Qian, Yuli</creatorcontrib><creatorcontrib>Ye, Yinghui</creatorcontrib><creatorcontrib>Shi, Yifu</creatorcontrib><creatorcontrib>Xu, Kaihong</creatorcontrib><creatorcontrib>Xu, Jianyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Jun</au><au>Zhang, Xinmei</au><au>Qian, Yuli</au><au>Ye, Yinghui</au><au>Shi, Yifu</au><au>Xu, Kaihong</au><au>Xu, Jianyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chin Med J (Engl)</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>116</volume><issue>5</issue><spage>777</spage><epage>780</epage><pages>777-780</pages><issn>0366-6999</issn><abstract>To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM).
Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from the blood samples of 68 Han Chinese women with endometriosis and 28 without endometriosis.
The frequencies of GSTM1 and GSTT1 null genotypes in women with endometriosis were 0.721 (49/68) and 0.779 (53/68), respectively, and in women without endometriosis were 0.429 (12/28) and 0.321 (9/28), respectively. There was a significant difference with regard to the frequencies of GSTM1 and GSTT1 null genotypes between the women with and without endometriosis (P < 0.01). Furthermore, the frequencies of GSTM1 and GSTT1 null genotypes were significantly higher in the patients with stage III and IV endometriosis [0.731 (38/52) and 0.788 (41/52), respectively] than in women without endometriosis (P < 0.01), and the frequency of GSTT1 null genotype was statistically higher in patients with stage I and II endometriosis [0.75 (12/16)] than in the women without endometriosis (P < 0.01). No correlation between GSTM1 and GSTT1 null genotypes and age, induced abortion or dysmenorrhea was detected in this study (P > 0.05).
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.</abstract><cop>China</cop><pub>Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China</pub><pmid>12875700</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Case-Control Studies Endometriosis - enzymology Endometriosis - genetics Endometriosis - pathology Female Genotype Glutathione Transferase - genetics Humans Risk Factors |
| title | Glutathione S-transferase M1 and T1 genotypes and endometriosis risk: a case-controlled study |
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