鼓室给药治疗难治性梅尼埃病的研究进展

梅尼埃病(Ménière's disease,MD)是以反复发作的眩晕、听觉障碍、耳鸣和耳胀满感为典型特征的突发性内耳疾病,膜迷路积水为基本的病理基础。膜迷路积水考虑与耳蜗微循环障碍、内淋巴液生成及吸收平衡失调等有关。虽然目前内耳药物代谢动力学研究的结果差异较大,经鼓室局部给药,使药物通过圆窗膜选择性的通透作用进入内耳,优于口服或其他胃肠外给药的效果,用药量较少,能在内耳局部达到较高的药物浓度,可避免全身用药可能引起的不良反应。...

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Veröffentlicht in:中国中西医结合耳鼻咽喉科杂志 2015, Vol.23 (3), p.237-240
1. Verfasser: 吕凌云 佘万东
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description 梅尼埃病(Ménière's disease,MD)是以反复发作的眩晕、听觉障碍、耳鸣和耳胀满感为典型特征的突发性内耳疾病,膜迷路积水为基本的病理基础。膜迷路积水考虑与耳蜗微循环障碍、内淋巴液生成及吸收平衡失调等有关。虽然目前内耳药物代谢动力学研究的结果差异较大,经鼓室局部给药,使药物通过圆窗膜选择性的通透作用进入内耳,优于口服或其他胃肠外给药的效果,用药量较少,能在内耳局部达到较高的药物浓度,可避免全身用药可能引起的不良反应。
doi_str_mv 10.16542/j.cnki.issn.1007-4856.2015.03.027
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identifier ISSN: 1007-4856
ispartof 中国中西医结合耳鼻咽喉科杂志, 2015, Vol.23 (3), p.237-240
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subjects 庆大霉素
梅尼埃病
糖皮质激素
难治性
鼓室给药
title 鼓室给药治疗难治性梅尼埃病的研究进展
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