Renovascular hypertension causes cerebral vascular remodeling
Renovascular hypertensive rats （RHRs） were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller l...
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| Veröffentlicht in: | 中国神经再生研究（英文版） 2011-09, Vol.6 (25), p.1977-1981 |
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| container_end_page | 1981 |
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| container_issue | 25 |
| container_start_page | 1977 |
| container_title | 中国神经再生研究（英文版） |
| container_volume | 6 |
| creator | Yamei Tang Xiangpen Li Yi Li Qingyu Shen Xiaoming Rong Ruxun Huang Ying Peng |
| description | Renovascular hypertensive rats （RHRs） were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2011.25.010 |
| format | Article |
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All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.</description><identifier>ISSN: 1673-5374</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2011.25.010</identifier><language>eng</language><publisher>Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China%Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China</publisher><subject>内皮细胞 ; 肾性 ; 脑动脉 ; 脑缺血 ; 血栓形成 ; 血管重塑 ; 高渗透性 ; 高血压</subject><ispartof>中国神经再生研究（英文版）, 2011-09, Vol.6 (25), p.1977-1981</ispartof><rights>Copyright © Wanfang Data Co. Ltd. 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The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.</description><subject>内皮细胞</subject><subject>肾性</subject><subject>脑动脉</subject><subject>脑缺血</subject><subject>血栓形成</subject><subject>血管重塑</subject><subject>高渗透性</subject><subject>高血压</subject><issn>1673-5374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo9j19LwzAUxfOg4Jx-hwq-SWP-NEn74IMMncJAEH0uaXLTtXTpTFZl-_RGJoMLF-75cc85CN1Sgnklq_sedzF6TKXiueCqwIxQipnAhJIzNDvdL9BljD0hoqwYn6GHd_Djt45mGnTI1vsthB342I0-M3qKEDMDAZqgh-xEBdiMFobOt1fo3OkhwvX_nqPP56ePxUu-elu-Lh5XuWFU7XJalkwapYARsKKxxFHqCmUVWAJONmlsyQsnGlYkgVHKtWy0M8IJQbTmc3R3_PujvdO-rftxCj451oc29oe472v468tEapvomyNt1qNvv1LOehu6jQ77mlclJ7Kq-C8OlFvw</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Yamei Tang Xiangpen Li Yi Li Qingyu Shen Xiaoming Rong Ruxun Huang Ying Peng</creator><general>Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China%Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20110901</creationdate><title>Renovascular hypertension causes cerebral vascular remodeling</title><author>Yamei Tang Xiangpen Li Yi Li Qingyu Shen Xiaoming Rong Ruxun Huang Ying Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c217t-18826c77e20ed5bd0f11f47d7ed0ef6bf6bd834f5b241f42113a6bafc5f550aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>内皮细胞</topic><topic>肾性</topic><topic>脑动脉</topic><topic>脑缺血</topic><topic>血栓形成</topic><topic>血管重塑</topic><topic>高渗透性</topic><topic>高血压</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamei Tang Xiangpen Li Yi Li Qingyu Shen Xiaoming Rong Ruxun Huang Ying Peng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>中国神经再生研究（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamei Tang Xiangpen Li Yi Li Qingyu Shen Xiaoming Rong Ruxun Huang Ying Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renovascular hypertension causes cerebral vascular remodeling</atitle><jtitle>中国神经再生研究（英文版）</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>6</volume><issue>25</issue><spage>1977</spage><epage>1981</epage><pages>1977-1981</pages><issn>1673-5374</issn><abstract>Renovascular hypertensive rats （RHRs） were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.</abstract><pub>Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China%Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China</pub><doi>10.3969/j.issn.1673-5374.2011.25.010</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1673-5374 |
| ispartof | 中国神经再生研究（英文版）, 2011-09, Vol.6 (25), p.1977-1981 |
| issn | 1673-5374 |
| language | eng |
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| source | Medknow Open Access Medical Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 内皮细胞 肾性 脑动脉 脑缺血 血栓形成 血管重塑 高渗透性 高血压 |
| title | Renovascular hypertension causes cerebral vascular remodeling |
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