Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury

Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury

In vitro cultured human neuroblastoma SH-SY5Y cells were pretreated with 50 or 5 ug/mL geniposide for 12 hours and exposed to 400 umol/L corticosterone. Corticosterone exposure in cultures not pretreated with geniposide resulted in inhibited cell growth, reduced cell survival, and increased P53 and...

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Veröffentlicht in:中国神经再生研究（英文版） 2011-07, Vol.6 (21), p.1618-1622
1. Verfasser: Liping Chen Fawei Wang Miao Geng Hongyan Chen Dongmei Duan
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Sprache:eng
Schlagworte:
体外培养
保护
损伤
栀子苷
皮质酮
神经母细胞瘤
蛋白表达
预处理
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container_issue 21
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container_title 中国神经再生研究（英文版）
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creator Liping Chen Fawei Wang Miao Geng Hongyan Chen Dongmei Duan
description In vitro cultured human neuroblastoma SH-SY5Y cells were pretreated with 50 or 5 ug/mL geniposide for 12 hours and exposed to 400 umol/L corticosterone. Corticosterone exposure in cultures not pretreated with geniposide resulted in inhibited cell growth, reduced cell survival, and increased P53 and P21 protein expression. However, in geniposide pretreated SH-SY5Y cells, cell viability and the number of cells in the G2 phase of the cell cycle were significantly increased, P21 and P53 protein expression was reduced, and cell apoptosis was inhibited following corticosterone exposure. These results indicate that geniposide can protect SH-SY5Y cells against high-dose corticosterone-induced injury.
doi_str_mv 10.3969/j.issn.1673-5374.2011.21.003
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subjects 体外培养
保护
损伤
栀子苷
皮质酮
神经母细胞瘤
蛋白表达
预处理
title Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury
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